Section outline

  • No Attendance Required: Vaccines
    What are vaccines and how does their development and use in practice differ from therapeutics. Vaccine safety and public perception; chance association vs. cause and effect. Importance of other governmental (e.g. CDC) and multinational (e.g. WHO) organizations. Evolution of antigen discovery and 'smart' adjuvants. Illustrative case studies including vaccines against (a) meningococcus ACWY, (b) meningococcal B, (d) influenza and pandemic influenza, (e) group B strep. Commercial considerations.

    Faculty:  Richard Chin

    Location:      China Basin 6702

    • Session Slides:

    • Scharschmidt Vaccines - Part 1 - 2012 File
    • Scharschmidt Vaccines - Part 2 - 2012 File
    • Scharschmidt Vaccines - Part 3 File
    • Scharschmidt Vaccines - Part 4 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

    • Guidance for Industry: General Principles for the Development of Vaccines to Protect Against Global Infectious Diseases URL
    • Margarit, I. Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm . J Infect Dis. 2009 Jan 1;199(1):108-15. File
      Not available unless: Your ID number contains 02
    • Reverse vaccinology: developing vaccines in the era of genomics. Sette A, Rappuoli R. Immunity. 2010 Oct 29;33(4):530-41. Review. PMID: 21029963 File
      Not available unless: Your ID number contains 02

    • Assignment:

      The assignment for the Vaccine lecture is to download a freedom of information summary from the FDA - http://www.fda.gov/BiologicsBloodVaccines/ucm133705.htm and comment on the development program.

    • Assignment Due Date:  May 21, 2014