Section outline

  • Lecture 1: Course overview, the diagnostic process, and measures of interobserver agreement

    Introduction to the course and how we will teach it.

    Evidence-Based Medicine: 1) refining disease probabilities; 2) quantifying  treatment effects. 

    Diagnosis: assigning the right name to a patient's illness versus using test results to guide treatment decisions.

    Inter-rater agreement: concordance, unweighted Kappa, linear and quadratic-weighted Kappa.

    Faculty:  Michael Kohn

    Location:  Mission Hall 1400

    • Prospectus:

    • Session Slides:

    • Lec 1 Overview diagnosis kappa 2019-0919 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to Registered students only
    • Lecture 1 from 2017 URL

      1:09:30 Weighted kappa.

      1:27:00 What's a good kappa?

      On a laptop or desktop you should be able to play back at 2X speed.  This does not appear to work on a mobile device.  If you use 2X, you can watch from 1:09 to the end of the lecture in 10 minutes.

      Not available unless: You belong to Registered students only

    • Required Reading from Evidence-Based Diagnosis, 2nd Edition (EBD-2), which hasn't been published.

      Chapter 0 (Preface), Chapter 1, & Chapter 5 (posted below as Word documents or pdf proofs)

    • EBD-2 Ch 0 -- Preface File
    • EBD 2 Ch 1 -- Introduction Understanding diagnosis and diagnostic testing File
    • EBD-2 Ch 5 -- Reliability and Measurement Error File

      Skip from "Reiliability of Continuous Measurements" on Page 12 up to "Using studies of reliability from the literature" on Page 21.

      This section covers Bland-Altman plots (which you will cover later this quarter in Epi 203) and calibration (which we will cover in Session 5 on "Evaluating Predictions").


    • Problem Set # 0:  Think about answers to the Ch 1 exercises posted below.  (You do not need to turn them in.)

       

    • Problem Set # 0 -- Understanding Diagnosis File

      In section on 9/19, we will discuss these questions.  Try to think about them and jot down some notes for yourself, but we won't be collecting or grading your answers.

    • Assignment Answer Key (Access restricted to registered students):

    • Problem Set #0 with Answers File

    • Optional Reading:

    • Multi-Rater Kappa File
    • Kohn (2013) Understanding Evidence-Based Diagnosis File
      Not available unless: Your ID number contains 02

    • Resources:

    • Martina Stuerer Clinical Epi Lecture Notes lectures 1-3 corrected 2016-1013 File
    • Martina Stuerer Clinical Epi Lecture Notes lectures 4-8 corrected 2016-1013 File
    • EBD-1 Errata-As of 2015-0915 File
    • TBN's Document Repository website URL