Course: BIOSTAT 209: Biostatistical Methods for Clinical Research III (Spring 2016)

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Biostatistical Methods In Clinical Research III BIOSTAT 209 Spring 2016 (3 units). Course Director: John Kornak, PhD. Associate Professor, Department of Epidemiology and Biostatistics

Select section Tuesday, March 29, 2016; 10:30 AM - 12:00 PM

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Tuesday, March 29, 2016; 10:30 AM - 12:00 PM
Lecture: Survival data
Survival data, hazards functions, hazard ratios, basics of the Cox model.

Faculty: John Kornak

Location: Mission Hall 1400
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  lectureS1-2016 File
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  Required Reading:
  
  Useful to review Chapter 3.5 in advance
  
  Chapters 6.1-6.2.4, VGSM
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Select section Thursday, March 31, 2016; 10:30 AM - 12:30 PM

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Thursday, March 31, 2016; 10:30 AM - 12:30 PM
Computer Lab: Survival analysis data

Faculty: Barbara Grimes, John Kornak

Location: Mission Hall 1400
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Select section Tuesday, April 5, 2016; 10:30 AM - 12:00 PM

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Tuesday, April 5, 2016; 10:30 AM - 12:00 PM
Lecture: Survival data
Cox model with binary, categorical and continuous predictors; confounding, mediation and interaction; adjusted survival curves.

Faculty: John Kornak

Location: Mission Hall 1400
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  Required Reading:
  
  Chapters 6.2.5-6.2.13, VGSM
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Select section Thursday, April 7, 2016; 10:30 AM - 12:30 PM

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Thursday, April 7, 2016; 10:30 AM - 12:30 PM
Computer Lab: Survival analysis data

Faculty: Barbara Grimes, John Kornak

Location: Mission Hall 1400
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  Assignment:
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Select section Tuesday, April 12, 2016; 10:30 AM - 12:00 PM

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Tuesday, April 12, 2016; 10:30 AM - 12:00 PM
Lecture: Survival Data
Extensions and Diagnostics for the Cox Model: time dependent covariates; stratified Cox model; model checking for the Cox model.

Faculty: John Kornak

Location: Mission Hall 1400
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  Session Slides:
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  lectureS3-2016 File
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  Required Reading:
  
  Chapters 6.3-6.5, VGSM
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Select section Tuesday, April 12, 2016; 12:00 PM - 1:00 PM

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Tuesday, April 12, 2016; 12:00 PM - 1:00 PM
Homework Session

Faculty: John Kornak

Location: Mission Hall 1400
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  survhw1-answ-2016 File
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Select section Thursday, April 14, 2016; 10:30 AM - 12:30 PM

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Thursday, April 14, 2016; 10:30 AM - 12:30 PM
Computer Lab: Survival analysis data

Faculty: Barbara Grimes, John Kornak

Location: Mission Hall 1400
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  Required Reading:
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Select section Tuesday, April 19, 2016; 10:30 AM - 12:00 PM

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Tuesday, April 19, 2016; 10:30 AM - 12:00 PM
Lecture: Common biostatistical problems
Misinterpretation of p-values; estimates and confidence intervals; accuracy versus conservatism.

Faculty: John Kornak

Location: Mission Hall 1400
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  Homework paper HbA1c disparities File
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  Homework paper Uganda ART pregnancy File
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  Assignment Due Date: Thursday, April 21 at start of class
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Select section Tuesday, April 19, 2016; 12:00 PM - 1:00 PM

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Tuesday, April 19, 2016; 12:00 PM - 1:00 PM
Homework Sessions

Faculty: John Kornak

Location: Mission Hall 1400
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Select section Thursday, April 21, 2016; 10:30 AM - 12:00 PM

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Thursday, April 21, 2016; 10:30 AM - 12:00 PM
Lecture: Common biostatistical problems and survival analysis
Discussion of readings. Competing risks survival analysis

Faculty: John Kornak

Location: Mission Hall 1400
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  Session Slides:
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  lectureS4-2016 File
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Select section Tuesday, April 26, 2016; 10:30 AM - 12:00 PM

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Tuesday, April 26, 2016; 10:30 AM - 12:00 PM
Lecture: Repeated measures data
Introduction to repeated measures data; correlation structures.

Faculty: Chuck McCulloch

Location: Mission Hall 1400
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  Repeated Measures Lecture 1 File
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  Repeated Measures Lecture 1 File
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  Required Reading:
  
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  Assignment Due Date: May 10 at the beginning of class
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Select section Thursday, April 28, 2016; 10:30 AM - 12:30 PM

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Thursday, April 28, 2016; 10:30 AM - 12:30 PM
Computer Lab: Repeated measures data

Faculty: Barbara Grimes, Chuck McCulloch

Location: Mission Hall 1400
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  Required Reading:
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Select section Tuesday, May 3, 2016; 10:30 AM - 12:00 PM

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Tuesday, May 3, 2016; 10:30 AM - 12:00 PM
Lecture: Repeated measures data
Fixed and random factors; prediction; Stata’s XTMIXED and XTGEE, model checking.

Faculty: Chuck McCulloch

Location: Mission Hall 1400
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  Session Slides:
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  Repeated measures lecture 2 File
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  Required Reading:
  
  Chapter 7.4-7.7, VGSM
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  Assignment: Optional narrative description
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Select section Thursday, May 5, 2016; 10:30 AM - 12:30 PM

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Thursday, May 5, 2016; 10:30 AM - 12:30 PM
Computer Lab: Repeated measures data

Faculty: Barbara Grimes, Chuck McCulloch

Location: Mission Hall 1400
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  Required Reading:
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  Assignment:
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Select section Tuesday, May 10, 2016; 10:30 AM - 12:00 PM

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Tuesday, May 10, 2016; 10:30 AM - 12:00 PM
Lecture: Repeated measures data
Generalized linear models; non-normal outcomes; robust standard errors; use of nonlinear link functions.

Faculty: Chuck McCulloch

Location: Mission Hall 1400
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Select section Thursday, May 12, 2016; 10:30 AM - 12:30 PM

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Thursday, May 12, 2016; 10:30 AM - 12:30 PM
Computer Lab: Repeated measures data

Faculty: Barbara Grimes, Chuck McCulloch

Location: Mission Hall 1400
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  Required Reading:
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  Assignment:
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  Repeated measures lab 3 File
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Select section Tuesday, May 17, 2016; 10:30 AM - 12:00 PM - No Class

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Tuesday, May 17, 2016; 10:30 AM - 12:00 PM - No Class
Lecture: No Class. Week reserved for finishing mentored data.
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  Homework Assignment #5
Select section Thursday, May 19, 2016; 10:30 AM - 12:30 PM - No Class

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Thursday, May 19, 2016; 10:30 AM - 12:30 PM - No Class
Computer Lab: No Class. Week reserved for finishing mentored data.
Select section Tuesday, May 24, 2016; 10:00 AM - 1:00 PM

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Tuesday, May 24, 2016; 10:00 AM - 1:00 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: Mission Hall 1402, 2106, 2107
Select section Thursday, May 26, 2016; 10:00 AM - 1:00 PM

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Thursday, May 26, 2016; 10:00 AM - 1:00 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: Mission Hall 1402, 2106, 2107
Select section Tuesday, May 31, 2016; 10:00 AM - 1:00 PM

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Tuesday, May 31, 2016; 10:00 AM - 1:00 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: Mission Hall 1402, 2106, 2107
Select section Thursday, June 2, 2016; 10:00 AM - 1:00 PM

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Thursday, June 2, 2016; 10:00 AM - 1:00 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: Mission Hall 1402, 2106, 2107

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July 2026

Section outline

Computer Lab: No Class. Week reserved for finishing mentored data.