Section outline

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  • Tuesday, February 12, 2019; 10:30 AM – 12:00 PM

    Lecture:  Design of RCTs:  How to avoid bias and achieve valid results


    Faculty:  Joan F. Hilton

    Location:      Mission Hall 1407

    • Session Slides:

    • Biostat226 Lecture1 2019 v1 File
      Not available unless: You belong to a group in Registered Students Only

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

    • Perera 2007 Interventions File
    • Wittes 2009 MissingOutcomes File
    • Vickers Altman 2013 Missing File
    • White Horton 2011 MissingOutcomes File

    • Optional Reading:

    • DFF TOC Data Monitoring in Clinical Trials File

    • Assignment:

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, February 19, 2019; 10:30 AM – 12:00 PM

    Lecture: Analysis issues:  Baseline covariates; Efficacy and Safety Outcomes

    Faculty:  Joan F. Hilton

    Location:      Mission Hall 1407

    • Session Slides:

    • Biostat 226 2019 Lect2 v1r File
      Not available unless: You belong to a group in Registered Students Only
    • Biostat 226 2019 Lect2 v1r.pptx File
      Not available unless: You belong to a group in Registered Students Only

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

    • Austin 2010 Baseline File
    • Vickers Altman 2013 ChangeScores File
    • Cole Altman 2017 Transf File
    • Lineberry Berlin 2016 Safety File

    • Assignment: Optional narrative description

  • Tuesday, February 26, 2019; 10:30 AM – 12:00 PM

    Lecture: Monitoring trials for efficacy, futility, and patient safety

    Faculty:  Joan F. Hilton

    Location:      Mission Hall 1407

    • Session Slides:

    • Biostat 226 2019 Lect3 File
      Not available unless: You belong to a group in Registered Students Only
    • Biostat 226 2019 Lect3.pptx File
      Not available unless: You belong to a group in Registered Students Only

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch 2018 Lecture URL
      Not available unless: You belong to a group in Registered Students Only

    • Required Reading:

    • WHI Monitoring File
      Not available unless: Your ID number starts with 02
    • Demets 2006 futility File

    • Optional Reading:

    • DFF Ch2 Summ LessonsLearned File
      Not available unless: Your ID number starts with 02
    • RCTs stopped early File
      Not available unless: Your ID number starts with 02

    • Assignment: Optional narrative description

  • Tuesday, March 5, 2019; 10:30 AM – 12:00 PM

    Lecture: Cluster randomized design

    Faculty:  Joan F. Hilton

    Location:      Mission Hall 1407

    • Session Slides:

    • Biostat 226 2019 Lecture4 File
      Not available unless: You belong to a group in Registered Students Only

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

    • Wright 2015 CRD File

    • Optional Reading:

    • Gao 2015 CRD File
    • Walters 2001 CRT File
    • Minian 2018 File

    • Assignment: Optional narrative description

  • Tuesday, March 12, 2019; 10:30 AM – 12:00 PM

    Lecture:  Precision Medicine I:  SMART (Adaptive) Trials


    Faculty:  Joan F. Hilton

    Location:      Mission Hall 1407

    • Session Slides:

    • Biostat 226 2019 Lect5 File
      Not available unless: You belong to a group in Registered Students Only

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

    • ADHD NahumShani 2012 File
    • Extend NahumShani 2017 File
    • Murphy 2012 File

    • Assignment: Optional narrative description

  • Tuesday, March 19, 2019; 10:30 AM – 12:00 PM

    Lecture: Precision Medicine II:  N-of-1 Trials

    Faculty:  Joan Hilton

    Location:      Mission Hall 1407

    • Session Slides:

    • Lecture6 2019 File
      Not available unless: You belong to a group in Registered Students Only
    • Lecture6 2019 File
      Not available unless: You belong to a group in Registered Students Only
    • STAMPEDE Platform File
      Not available unless: You belong to a group in Registered Students Only

    • Required Reading:

    • Stone 2009 File
    • Pocock 2017 Noninferiority File

    • Assignment Due Date:  Homework 6 is also a take-home final exam. Thus it includes questions from all 6 lectures, is longer than average, and will count for 25% of your grade.  It is due Tuesday, Mar 26.