Section outline

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  • Monday, January 7, 2019; 1:00 PM - 3:00 PM

    Lecture: Introduction to NTDs, overview of the course and Principles of vector biology

    Faculty:  Caryn Bern and Jimee Hwang

    Location:  Mission Hall 1109

    • Required Reading:

    • Yamey G, Torreele E. The world's most neglected diseases. BMJ 2002;325:176-7. File
      Not available unless: Your ID number contains 02
    • Ribeiro J.M.C., Valenzuela J.G. Vector Biology In: Guerrant RL, Walker DH, Weller PF, eds. Tropical infectious diseases: principles, pathogens and practice. Edinburgh, Scotland: Churchill Livingstone Elsevier; 2011:45-51. File
      Not available unless: Your ID number contains 02

    • Optional Reading:


    • Pates H, Curtis C. Mosquito behaviour and vector control. Annu Rev Entomol 2005: 50: 53–70 File
      Not available unless: Your ID number contains 02
    • World Health Organization. First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases. WHO/HTM/NTD/2010.1. File
      Not available unless: Your ID number contains 02

    • Assignment:

       

    • Article review/discussion sign-up Forum

      Please use the forum to post your date preference.

      Date

      Article review/discussion

      Student sign-up

      Leishmaniasis

      Chagas disease

      Trachoma 

      Arboviruses

      Malaria 

      Schistosomiasis 

  • Monday, January 14, 2019; 1:00 PM - 3:00 PM

    Lecture: Trachoma and Article(s) review and discussion

    Faculty:  Tom Lietman 

    Location:  Mission Hall 1109

    • Session Slides:

    • Required Reading:

    • Taylor HR, Burton MJ, Haddad D, West S, Wright H. Lancet. 2014 Jul 16. File
      Not available unless: Your ID number starts with 02

    • Optional Reading:

    • Is Credé’s prophylaxis for ophthalmia neonatorum still valid. Schaller UC and Klauss V. Bulletin of the WHO, 2001. 79 (3) 262-263. (Or if someone wants the original German: Die Verhutüng der Augenentzündung der Neugeborenen. Credé CSF. Arhiv für Gynaekolo File
      Not available unless: Your ID number contains 02

    • Articles for Student Seminars:

    • Azithromycin in control of trachoma. Schachter J, West SK, Mabey D, Dawson CR, Bobo L, Bailey R, Vitale S, Quinn TC, Sheta A, Sallam S, Mkocha H, Mabey D, Faal H. Lancet. 1999 Aug 21;354(9179):630-5. File
      Not available unless: Your ID number contains 02
    • Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection. Taylor HR, Pacqué M, Muñoz B, Greene BM. Science. 1990 Oct 5;250(4977):116-8. File
      Not available unless: Your ID number contains 02
    • Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial. Sommer A, Tarwotjo I, Djunaedi E, West KP Jr, Loeden AA, Tilden R, Mele L. Lancet. 1986 May 24;1(8491):1169-73. File
      Not available unless: Your ID number contains 02

  • Monday, January 21, 2019; No Class - MLK Holiday

  • Monday, January 28, 2019; 1:00 PM - 3:00 PM

    Lecture: Chagas disease and Article(s) review and discussion

    Faculty:  Caryn Bern

    Location:  Mission Hall 1109

    • Session Slides:

    • Required Reading:

    • Bern C. Chagas' Disease. N Engl J Med. 2015 Nov 5;373(19):1882. doi: 10.1056/NEJMc1510996. File
      Not available unless: Your ID number starts with 02
    • Gurtler RE. Sustainability of vector control strategies in the Gran Chaco Region: current challenges and possible approaches. Memorias do Instituto Oswaldo Cruz 2009;104 Suppl 1:52-9. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Clark EH, Sherbuk J, Okamoto E, et al. Hyperendemic Chagas disease and the unmet need for pacemakers in the Bolivian Chaco. PLoS Negl Trop Dis 2014;8:e2801. File
      Not available unless: Your ID number contains 02

    • Articles for Student Seminar:  Mathematical Modeling to Access Impact of Chagas Vector Control Programs

    • Samuels AM, Clark EH, Galdos-Cardenas G, et al. Epidemiology of and impact of insecticide spraying on Chagas disease in communities in the Bolivian Chaco. PLoS Negl Trop Dis 2013;7:e2358. File
      Not available unless: Your ID number contains 02
    • Delgado S, Castillo Neyra R, Quispe Machaca VR, et al. A history of chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. PLoS Negl Trop Dis 2011;5:e970. File
      Not available unless: Your ID number contains 02

  • Monday, February 4, 2019; 1:00 PM - 3:00 PM

    Lecture: Leishmaniasis and Article(s) review and discussion

    Faculty:  Caryn Bern

    Location:  Mission Hall 1109

    • Session Slides:

    • Required reading:

    • Burza S, Croft SL, Boelaert M. Leishmaniasis. Lancet. 2018 Sep 15;392(10151):951-970. doi: 10.1016/S0140-6736(18)31204-2 File
      Not available unless: Your ID number starts with 02
    • Quinnell RJ, Courtenay O. Transmission, reservoir hosts and control of zoonotic visceral leishmaniasis. Parasitology 2009 Oct 16:1-20. File
      Not available unless: Your ID number starts with 02

    • Optional reading:

    • Alvar J, Velez ID, Bern C, et al. Leishmaniasis worldwide and global estimates of its incidence. PloS one 2012;7:e35671. File
      Not available unless: Your ID number contains 02
    • World Health Organization. Control of the leishmaniases. World Health Organ Tech Rep Ser 2010: 1-186. File
      Not available unless: Your ID number contains 02

    • Articles for Student Seminar: Infection reservoir control: L. infantum in Brazil and L. donovani in India

       

    • Courtenay O, Quinnell RJ, Garcez LM, Shaw JJ, Dye C. Infectiousness in a cohort of Brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. The Journal of infectious diseases 2002 Nov 1;186(9):1314-20. File
      Not available unless: Your ID number starts with 02
    • Medley GF, Hollingsworth TD, Olliaro PL, Adams ER. Health-seeking behaviour, diagnostics and transmission dynamics in the control of visceral leishmaniasis in the Indian subcontinent. Nature. 2015 Dec 3;528(7580):S102-8. doi: 10.1038/nature16042. File
      Not available unless: Your ID number starts with 02

    • Optional extra reading related to student seminar:

    • Mondal D, Bern C, Ghosh D, Rashid M, Molina R, Chowdhury R, Nath R, Ghosh P, Chapman L, Alim A, Bilbe G, Alvar J. Quantifying the infectiousness of post-kala-azar dermal leishmaniasis towards sandflies. Clin Infect Dis. 2018 Oct 24 File
      Not available unless: Your ID number contains 02

  • Monday, February 11, 2019; 1:00 PM - 3:00 PM

    Lecture: Malaria and Article(s) review and discussion

    Faculty:  Jimee Hwang and Adam Bennett

    Location:      Mission Hall 1109

    • Session Slides:

    • Required Reading:

    • White, N. et. al. (2014) Malaria. Lancet 383: 723–35 File
      Not available unless: Your ID number starts with 02
    • Tusting LS, Bousema T, Smith DL, Drakeley C. Measuring changes in Plasmodium falciparum transmission: precision, accuracy and costs of metrics. Adv Parasitol. 2014;84:151-208 (Table 3.1 only) File
      Not available unless: Your ID number contains 02
    • Bhatt S. et. al. (2015) The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature 526: 207 File
      Not available unless: Your ID number contains 02
    • Chapter on Malaria in Lecture Notes on Tropical Medicine 7th ed. File
      Not available unless: Your ID number starts with 02

    • Articles for the Student Seminar:

    • Mogeni P, Williams TN, Fegan G, Nyundo C, Bauni E, Mwai K, et al. (2016) Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study. PLoS Med 13(6): e1002047. File
      Not available unless: Your ID number starts with 02
    • Hawley WA et al. Community-wide effects of permethrin-treated bed nets on child mortality and malaria morbidity in western Kenya. Am J Trop Med Hyg. 2003 Apr;68(4 Suppl):121-7. File
      Not available unless: Your ID number starts with 02

    • Optional Reading:

    • Bousema T, et al. (2016) The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial. PLoS Med 13(4): 1001993. File
      Not available unless: Your ID number starts with 02
    • Eisele, T. et. al. Short-term Impact of Mass Drug Administration With Dihydroartemisinin Plus Piperaquine on Malaria in Southern Province Zambia: A Cluster-Randomized Controlled Trial. (2016) Journal of Infectious Diseases 214:1831–9 File
      Not available unless: Your ID number starts with 02
    • Daniels, R. et. al. (2015) Modeling malaria genomics reveals transmission decline and rebound in Senegal. PNAS 112 (22): 7067–7072 File
      Not available unless: Your ID number starts with 02

  • Monday, February 18, 2018; No Class - President's Day

  • Monday, February 25, 2019; 1:00 PM - 3:00 PM

    Lecture: Onchocerciasis and Article(s) review and discussion

    Faculty:  Jeremy Keenan

    Location:  Mission Hall 1109

    • Session Slides:

    • Required Reading:

      Hoeuraf AM. Onchocerciasis. In: Tropical Infectious Diseases: Principles, Pathogens, and Practice (Third edition) 2011; pp741-749.


    • Optional Reading:

    • Unnasch TR, Golden A, Cama V, Cantey PT. Diagnostics for onchocerciasis in the era of elimination. Int Health. 2018;10(suppl_1):i20-i26. File
      Not available unless: Your ID number starts with 02
    • Kamgno J et al. A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa-Endemic Areas. N Engl J Med. 2017;377(21):2044-2052. File
      Not available unless: Your ID number starts with 02

    • Articles for student seminar:

    • Lont YL, et al. Modelling Anti-Ov16 IgG4 Antibody Prevalence as an Indicator for Evaluation and Decision Making in Onchocerciasis Elimination Programmes. PLoS Negl Trop Dis. 2017;11(1):e0005314. File
      Not available unless: Your ID number starts with 02
    • Opoku et al. A. Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial. Lancet. 2018;392(10154):1207-1216. File
      Not available unless: Your ID number starts with 02
    • Walker M, Stolk WA, Dixon MA, Bottomley C, Diawara L, Traoré MO, de Vlas SJ, Basáñez MG. Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal. Epidemics. 2017;18:4-15. File
      Not available unless: Your ID number starts with 02

  • Monday, March 4, 2019; 1:00 PM - 3:00 PM

    Lecture: Arboviruses and Article(s) review and discussion

    Faculty:  Desiree LaBeaud

    Location:  Mission Hall 1109

    • Required Reading:

    • Weaver and Reisen. Present and Future Arboviral Threats. Antiviral Research. Feb 2010. File
      Not available unless: Your ID number starts with 02
    • Petersen et al. Zika Virus. N Engl J Med 2016; 374:1552-1563 DOI: 10.1056/NEJMra1602113 File
      Not available unless: Your ID number starts with 02

    • Articles for student seminar: Are novel approaches to vector control going to stop arboviral outbreaks?

    • Bourtzis et al. Harnessing mosquito–Wolbachia symbiosis for vector and disease control. Acta Tropica. 2014. File
      Not available unless: Your ID number contains 02
    • van den Hurk AF et al. (2012) Impact of Wolbachia on Infection with Chikungunya and Yellow Fever Viruses in the Mosquito Vector Aedes aegypti. PLoS Negl Trop Dis 6(11): e1892. doi:10.1371/journal.pntd.0001892 File
      Not available unless: Your ID number starts with 02
    • Black Alphey and James. Why RIDL is not SIT. Trends in Parasitology. August 2011. File
      Not available unless: Your ID number contains 02

  • Monday, March 11, 2019; 1:00 PM - 3:00 PM

    Lecture: NTDs, elimination and eradication

    For the last 2 classes, the plan is for students to take over these sessions to address elimination and eradication programs, especially those targeting NTDs not already discussed (lymphatic filariasis, onchocerciasis, dracunculiasis, human African trypanosomiasis).  We will ask for sign-ups for specific topics on Jan 30.

    Faculty:  Caryn Bern, various lecturers

    Location:      Mission Hall 1109

    • Session Slides:

    • Required Reading:

    • Hopkins DR. Disease Eradication. N Engl J Med 2013;368:54-63. File
      Not available unless: Your ID number contains 02
    • Molyneux Lancet 2016 NTD elimination File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Heymann DL. Disease Eradication and Control. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical infectious diseases: principles, pathogens and practice. Edinburgh, Scotland: Churchill Livingstone Elsevier; 2011:40-44. File
      Not available unless: Your ID number contains 02

  • Monday, March 18, 2019; 1:00 PM - 3:00 PM

    Lecture: NTD Eradication and elimination programs

     

    Faculty:  Caryn Bern, various instructors

    Location:      Mission Hall 1109

    • Session Slides: