HW8 Q3.
HI Mitzi,
I help with administration and data collection on a couple clinical trials on uterine fibroid treatments and I am intrigued by your question and wonder about differences in fibroids between women and men on various hormone therapy and uterine transplant (See attached Lancet Article on Uterine Transplant success from live and post mortem organ donors). I had only heard of uterine fibroids before as a uncommon condition until working on studies here and have seen in the literature and in our studies higher prevalence rates, size and severity in Latin and African American patients. The fibroids can potentially lead to uterine cancers and they are extremely symptomatic and painful. For your study since cancer might be very difficult to have as an observational endpoint you could perhaps look at Fibroids as they develop very quick! I'm not an MD, but I seem to remember that estrogen seems to increase their growth and transxamic acid in some cases. Maybe a multi level analysis on trends across men and women with estrogen vs. t therapy ?