Section outline

  • Lecture 2: Blinding, Intervention and Controls

    Definition and importance of blinding; strategies if the study can’t be blinded; strategies to evaluate blinding; considerations when choosing the intervention; multiple interventions; importance of the control or placebo; advantages and disadvantages of equivalence trials.

    Faculty: Deborah Grady

    Location (Access restricted to registered students): Zoom

    • Lecture Recording (watch prior to Thursday):

    • Blinding Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Blinding File
      Not available unless: You belong to a group in Registered Students Only
    • Interventions & Controls Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Intervention & Control File
      Not available unless: You belong to a group in Registered Students Only

    • Live Large Group Session (Access restricted to registered students): Thursday, 8:45am - 10:15am PT.  Brief formal review of lecture followed by question and answer discussion. Recorded lecture should be viewed prior to this session. 

      Zoom Info
      Meeting ID: 974 5907 9678
      Passcode: 013835

      https://ucsf.zoom.us/j/97459079678?pwd=T09paUFhdi91RHNLWG5uTHRrLzBmZz09


    • Session Audio/Video Recording (Access restricted to registered students):

    • Workshop 2_01.13.2022 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Required Reading:

      Designing Clinical Research (4th Edition), Chapter 10, pages 147-149.

    • Kong, et al. Effect of Electroacupuncture vs Sham Treatment on Change of Pain Severity Among Adults with Chronic Low Back Pain: A randomized clinical trial. JAMA Network Open 2020. File
      Not available unless: You belong to a group in Registered Students Only
    • Noseworthy H, et al. The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. Neurology 1994 44: 16-20. File
      Not available unless: Your ID number contains 02
    • Kirkley A, et al. A randomized trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2008 Sep 11;359(11):1097-107. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

      Fundamentals of Clinical Trials (5th Edition), Chapter 7.

    • Assignment & Due Dates for this week:

              1) Homework: Complete homework assignment #2 and submit to TAs by Tuesday, January 18, 2022, 5pm at UCSFClinicalTrials2022@gmail.com

              2) Protocol: Work on protocol assignment #1 and submit to your section leader by Thursday, January 18, 2022, 12pm. Please scroll above for sample protocols.

       

    • Homework L2 File
      Not available unless: You belong to a group in Registered Students Only

    • Assignment Answer Key (Access restricted to registered students):

    • Homework Answer Key for Assignment #2 File