Section outline

  • Lecture:  Evidence Based Medicine, Meta-Analysis, Case Studies

    Evidence-based medicine: the state of the art

    • Understand the genesis of evidence based medicine
    • Understand the use and application of ‘meta-analyses’ and ‘systematic reviews’ in the generation of evidence based medicine
    • Explore the value of meta analysis in regulatory decision making: the Vioxx example
    • Case Study:  Effect Measure Selection in MetaAnalysis – A Case study from Pharmacoepidemiology

    Faculty:  Michael Kelsh/ F. Callaghan

    Location:  Mission Hall 1407

    • Session Slides:

    • PV sample size power File
    • PV MetaAnalysis File
    • Lecture5b - Meta-Analysis Case Studies V2 File

    • Required Reading:

      Roundtable discussion of Vioxx/Avandia and other safety studies

    • Guyatt et al., Users’ Guides to the Medical Literature XXV. Evidence-Based Medicine. Principles for Applying the Users’ Guides to Patient Care. JAMA 284(10)-1290-1296, 2000 File
      Not available unless: Your ID number contains 02
    • Concato et al., Randomized, Controlled Trials, Observational Studies, and the Hierarchy Of Research Designs. N Engl J Med 342(25) 1887-92, 2000 File
      Not available unless: Your ID number contains 02
    • Juni et al., Risk of cardiovascular events and rofecoxib. cumulative meta-analysis. Lancet 364(9450) 2021-2029, 2004 File
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    • Poole 2007 Coffee and Myocardial Infarction. File
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    • Assignment:

      Student Presentations

    • New RAS-Mutant Pancreatic Adenocarcinoma With Combined BRAF and MEK Inhibition for Metastatic Melanoma File
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    • Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes File
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    • Inhibition of Mutated, Activated BRAF in Metastatic Melanoma File
      Not available unless: Your ID number contains 02
    • Caterson et al. - 2012 - Maintained intentional weight loss reduces cardiov File
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    • James et al. - 2010 - Effect of Sibutramine on Cardiovascular Outcomes i File
      Not available unless: Your ID number contains 02
    • Vemurafenib in patients with BRAFV600 mutated metastatic melanoma: an open-label, multicentre, safety study File
      Not available unless: Your ID number contains 02
    • RECORD RosiglitazoneRosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial File
      Not available unless: Your ID number contains 02
    • Progression of RAS-Mutant Leukemia during RAF Inhibitor Treatment File
      Not available unless: Your ID number contains 02