Section outline

  • Full-Class Online Conversation with Deborah Grady

    Recorded lecture segments by Tom Newman on Subjects and Variables:  Defining target and accessible populations; inclusion and exclusion criteria; balancing feasibility and generalizability; sampling; types of variables and measurements; maximizing precision and accuracy; example from Tom's research on hyperbilirubinemia in neonates.

    Full-class online conversation with Deborah Grady:  Join an online discussion with Dr. Grady about the week's lecture material, brief comments about clinical trials (upcoming week's lecture topic), her career in clinical research and advice for early career investigators, and Q&A with students about topics, concepts and specific projects, with facilitation by Dr. Pletcher.  We will use Zoom video conference technology, online polling, a brief online breakout discussion session.

    Location:  Online video conference, click here to join from PC, Mac, Linus iOS or Android, or telephone only at +1 646 558 8656 (US Toll) or +1 408 638 0968 (US Toll), Meeting ID: 831 131 839.  International numbers available, click here for information.


    • Session Slides:

    • Lecture 2 - Tom Newman - Subjects and Variables File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to Registered Students Only
    • Tom Newman - Lecture 2, Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Tom Newman - Lecture 2, Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Tom Newman - Lecture 2, Part 3 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment 2:

      • Read Chapters 3 and 4 of DCR-4
      • Watch Tom Newman’s recorded lecture segments on “Subjects and Variables” (see Materials)
      • Watch Mark Pletcher's recorded mini-lecture on "Study Design Basics" (See Materials)
      • Make an appointment to meet with your mentor sometime in the next 2 weeks
      • Write 1-page protocol outline for your study
      • Write <1 page "Study Subjects" section
      • Bring paper copy of writing to Small Group on Tuesday, and turn in revised version by Wednesday at Midnight
      • Do Exercise 3 (Chapter 3) and Exercise 3 (Chapter 4) of DCR-4 (Optional)
    • Assignment 2 Details File
    • Assignment 2 Example File

    • Materials:

    • Mark Pletcher - Mini-lecture - Study Design Basics Media Resource
      Not available unless: You belong to Registered Students Only

    • Optional reading from Tom Newman relevant to his Subjects and Variables lecture:

    • Newman 2006 NEJM Outcomes of TB 25 or more File
    • Newman 1991 AJDC Direct Bilirubin Measurements in Jaundiced Term Newborns File
    • Newman 2003 Stories Statistics BMJ File