Section outline

  • Lecture 7: Quantifying the benefits and harms of treatments using RCTS
    RCT checklist; importance of baseline incidence; measures of effect size: Relative risk (RR), relative risk reduction (RRR), Odds ratio (OR), Absolute risk reduction (ARR), Number needed to treat (NNT);   "Back of the Envelope Cost Effectiveness Analysis" 

    Faculty:  Ben Breyer

    Location:  Mission Hall 1400

    • Session Slides:

    • Session Audio/Video Recording (Access restricted to registered students):

    • Lec 7 RCT Breyer.ppt File
    • Watch (Mediasite version) URL
      Not available unless: You belong to a group in Registered Students Only
    • .mp4 URL
      Not available unless: You belong to M Laker

    • Required Reading from Evidence-Based Diagnosis, 2nd Edition (EBD-2), which hasn't been published.

      Chapter 8 (posted below as a Word document)

    • EBD2-Ch8 Quantifying treatment effects 2017-1023 For Posting.docx File
    • PPT SLIDES FOR HowDoWeKnowWhatWeKnow for CTSI 2012-0717 File

    • Optional Reading:

    • LeNoury 2015 BMJ Restoring Study 329 File
      Not available unless: You belong to a group in Registered Students Only
    • Newman 2004 NEJM Antidepressant Perspective File
      Not available unless: You belong to a group in Registered Students Only
    • Stempel 2016 NEJM AUSTRI study Advair v fluticasone alone File
      Not available unless: You belong to a group in Registered Students Only
    • Stolker 2014 Circulation rethinking composite endpoints in clinical trials File
    • Ciani 2013 BMJ Surrogate vs patient relevant outcomes File
    • Miner 2017 Am J Gastro Pecanatide for chronic constipation File

    • Resources: