Section outline

  • Lecture: Person-time and Bias in Cohorts (Pre-recorded; view on own)

    Fixed vs. open cohorts; the dynamic allocation of person-time in longitudinal cohorts; patient or survivor cohorts; particular bias issues discussed in the setting of patient cohorts (including selection bias, immortal-person time bias, measurement error bias, confounding by indication, and residual confounding); and how emulation of a target trial may help avoid some of these biases.

    Faculty: June Chan

    • Session Slides:

    • Coh PT Bias Part 1 OpenFix Calc EPI207_2018_slides File
    • Coh PT Bias Part 2 PT EPI207_2018_slides File
    • Coh PT Bias Part 3 SurvCoh Conf EPI207_2018_slides File
    • Coh PT Bias Part 4 Sel Bias ImmPT EPI207_2018_slides File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Person-time and Bias in Cohorts Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Person-time and Bias in Cohorts Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Person-time and Bias in Cohorts Part 3 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Person-time and Bias in Cohorts Part 4 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Required Reading:

      Chapter 7, Rothman, Greenland, & Lash 3rd Edition

      Choe, K.S., et al, Aspirin use and the risk of prostate cancer mortality in men treated with prostatectomy or radiotherapy. 2012, Journal of Clinical Oncology, 30(28), pp.3540-3544.

      https://www.ncbi.nlm.nih.gov/pubmed/22927523

    • Optional Reading:

      Emilsson L, García-Albéniz X, Logan RW, Caniglia EC, Kalager M, Hernán MA. Examining Bias in Studies of Statin Treatment and Survival in Patients With Cancer. JAMA Oncol. 2018, PubMed PMID: 28822996. https://www.ncbi.nlm.nih.gov/pubmed/28822996 

      Hernán MA et al, Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses J Clin Epid, 2016. https://www.ncbi.nlm.nih.gov/pubmed/27237061

    • Assignment:

    • HW3 Questions on Person Time and Bias DUE Jan31, 2018 File

    • Assignment Due Date: January 31, 2018 at the beginning of Small Group Section

    • Week #3 Homework Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

    • HW 3 Person Time & Bias KEY File
    • Choe et al JCO 2012 Wk 3 article with JMC comments File
    • Choe et al JCO 2012 Wk3 article with JMC comment summary File