Section outline

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    • Epidemiologic Methods II

      EPI 207 Winter 2016 (3 units)


      Course Director: Lydia B. Zablotska, MD, PhD.
    • Sign up to present your work-in-progress Forum

      Student oral presentations of research-in-progress:

      Please let us know if you would like to make a short presentation about your research project in-progress during the week when we are covering topics of interest to you.  There is no better way to learn the theoretical material than to work on an actual project.  And, as a bonus, you will get feedback from the whole class and might even find a collaborator!

      General guidelines:

      Choose a week when we will be discussing a topic of interest to you.  Let us know about it in advance.  Prepare a short 5-min presentation of your project and formulate 2-3 questions for the class.

      Best student presentation wins a prize!

      At the end of the course we will select the best presentation by popular vote. The winner will receive the latest (5th) edition of an excellent book by R. Friis and T. Sellers, Epidemiology for Public Health Practice.

    • News forum
    • Epi Methods II forum

      Forum for students to post questions and materials.

    • Mid-term Quiz

      The Mid-term Quiz will be held during the first 45 min of the class on February 12th. It will be a closed-book multiple-choice quiz containing 15 questions.  Please plan to attend the class on that day or contact us as soon as possible if you have any problems with scheduling.

    • Syllabus Epi Methods II Winter 2016 final rev File

  • Friday, January 8, 2016; 1:30 PM - 4:30 PM

    Lecture: Introduction: Causal theories and interrelationships between measures of disease occurrence

    Theories of causal inference
    Causal models and heuristics
    Counterfactual effect measures

     

    Faculty:  Lydia B. Zablotska

    Location:      Mission Hall 1407

    • Session Slides:

    • Week #1 slides File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Rothman, Greenland and Lash 2008 (RGL2008) Chs 2, 4, 12

      Not available unless: Your ID number contains 02

    • Recommended Reading:

      Rothman 2012 (R2012) Chs 1-3

      Not available unless: Your ID number contains 02

  • Friday, January 15, 2016; 1:30 PM - 4:30 PM

    Lecture: Observational Study Designs I
    Classifications of observational study designs, field methods for observational study designs, introduction to instrumentation and data collection methods, design features of cohort studies

    Faculty: Lydia Zablotska

    Location:      Mission Hall 1407

    • Session Slides:

    • Week #2 slides with ARS exercise answers File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      RGL 2008 Ch 6
      RGL 2008 Ch 7
      RGL 2008 Ch 24
      SNC 2015 Ch 6
      SNC 2015 Ch 13

    • SNC Ch 6 File
      Not available unless: Your ID number contains 02
    • SNC Ch13 File
      Not available unless: Your ID number contains 02

    • Recommended Reading:

      H&R2015 Ch 3

    • H&R2015 Part I, Ch 3 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • Week #2 Homework Submission Assignment

      Submit your homework for week #2. Deadline at 1PM on 1/15/2016.

      Available until January 15 2016, 1:00 PM

    • Assignment Answer Key (access restricted to registered students):

  • Friday, January 22, 2016; 1:30 PM - 4:30 PM

    Lecture: Observational study designs II

    Design features of case-control studies, special types of case-control studies

    Faculty:  Lydia Zablotska

    Location:      Mission Hall 1407

    • Session Slides:

    • Week #3 slides with In-Class Exercise answers File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      RGL2008 Ch 8 (pp111-124),

    • Recommended Reading:

      H&R2015 Ch 3

    • H&R2015 Part I, Ch 3 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • Fradet Dietary omega-3 and prostate cr Clin Cancer Res 2009 File
      Not available unless: Your ID number contains 02
    • Intro to CAP dataset review Stata File

    • Intro_to_CAP dataset files:

    • dataset codebook File
    • Intro_to_CAP_dataset File
    • Intro_to_CAP dataset for STATA users File

    • CAP dataset files:

    • CAP dataset File
    • CAP dataset for STATA users File
    • CAP dataset for STATA users - STATA File
    • Week #3 Homework Submission Assignment

      Submit your homework for week #3. Deadline at 1PM on 1/22/2016.

      Available until January 22 2016, 1:00 PM

    • Assignment Answer Key (access restricted to registered students):

  • Friday, January 29, 2016; 1:30 PM - 4:30 PM

    Lecture: Observational study designs III

    Less commonly used observational study designs, ecological and cross-sectional studies, surveys, case-only, case-crossover, case-time-control, special-exposure cohorts

    Faculty:  Lydia Zablotska

    Location:      Mission Hall 1407

    • Session Slides:

    • Week #4 slides File
    • OPTIONAL: Genetic study designs by L. Hindorff File
      Not available unless: Your ID number is 02

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      RGL2008 Ch 8 (pp 125-127)
      RGL2008 Ch 22 (pp 472-476)
      RGL2008 Ch 25
      RGL2008 Ch 28 (pp 573-575)

      RGL2008 Ch 30 (pp 605-606)

    • Optional Reading:

    • Basu Ecological study PLoS One 2013 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • Dufault and Klar 2011 File
      Not available unless: Your ID number contains 02
    • Gillespie Case-chaos studies AJE 2012 File
      Not available unless: Your ID number contains 02
    • Edelstein et al and McCarthy et al response 2014 File
      Not available unless: Your ID number contains 02
    • Stang and Jockel 2004 File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (access restricted to registered students):

  • Friday, February 5, 2016; 1:30 PM - 4:30 PM

    Lecture: Directed Acyclic Graphs (DAGs) and causal structures of different types of biases  

    Intro to causal inference; causal DAGs; DAGs and confounding; DAGs and selection bias.

    Faculty:  Cindy Leung

    Location:      Mission Hall 1402

    • Session slides:

    • Week 5 DAGs post File
    • Week 5 DAGs File

    • Dr. Leung's DAG:

      Cindys DAG from the blackboard.jpg

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      RGL 2008 Ch 12

      H&R 2015 Ch 6

    • Optional Reading:

               H&R 2015 Ch7-9

    • Examples of DAGs for recently published studies:

    • Ferrie et al 2013 File
      Not available unless: Your ID number contains 02
    • Sample DAG for Ferrie Atherosclerosis 2013 File
      Not available unless: Your ID number contains 02
    • Gage et al 2013 File
      Not available unless: Your ID number contains 02
    • Sample DAG for Gage AJE 2013 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • Le-Scherban et al 2014 File
      Not available unless: Your ID number contains 02
    • Hernan et al 2001 File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (access restricted to registered students):

  • Friday, February 12, 2016; 1:30 PM - 4:30 PM

    Lecture: Measurement theory and practice I

    Standardized approaches to measurement, methods of test development I: Item response theory, item analysis, scaling and factor analysis; Methods of test development II: Instrumental design, construction and interpretation in cross-cultural situations

    Faculty: Lydia Zablotska 

    Location:      Mission Hall 1407

    • Session Slides:

    • Week #6 slides File
      Not available unless: Your ID number contains 02

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      SNC 2015 Ch 8-10

    • SNC Ch 9 File
      Not available unless: Your ID number contains 02
    • SNC Ch 10 File
      Not available unless: Your ID number contains 02
    • SNC Ch 8 File
      Not available unless: Your ID number contains 02

    • Recommended Reading:

      RGL 2008 Ch 9-10

    • Discussion section readings and homework assignments:

    • DeVon et al. 2007 File
      Not available unless: Your ID number contains 02
    • Goodwin 2002 File
      Not available unless: Your ID number contains 02
    • Higgins and Straub 2006 File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (access restricted to registered students):

  • Friday, February 19, 2016; 1:30 PM - 4:30 PM

    Lecture: Measurement theory and practice II

    Overview of measurement theory, reliability and validity in epidemiological studies, study design features affecting precision of results, including effects of multiple comparisons, methods of sampling and estimation of sample size and statistical power

    Faculty:  Lydia Zablotska

    Location:  Mission Hall 1407

    • Session Slides:

    • Week 7 slides File
      Not available unless: Your ID number contains 02

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      SNC Ch 3-5, 7, 12, 14

    • SNC Ch 3 File
      Not available unless: Your ID number contains 02
    • SNC Ch 4 File
      Not available unless: Your ID number contains 02
    • SNC Ch 5 File
      Not available unless: Your ID number contains 02
    • SNC Ch 7 File
      Not available unless: Your ID number contains 02
    • SNC Ch 12 File
      Not available unless: Your ID number contains 02
    • SNC Ch 14 File
      Not available unless: Your ID number contains 02

    • Recommended Reading:

      RGL 2008 Ch 9-10

    • Keszei-Novak -Streiner-scales intro-2010 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • Stata Tutorials:

    • ICC File
    • Cronbach's alpha File
    • Factor Analysis File
    • Cohen's kappa File
    • Reliabilit and Validity Tutorial File

    • Homework and homework datasets:

    • CHIS File
    • W#7 FA dataset File
    • ICC missing File

    • Assignment Answer Key (access restricted to registered students):

  • Friday, February 26, 2016; 1:30 PM - 4:30 PM

    Lecture: Confounding

    Measured and unmeasured confounding; instrumental variables and propensity scores.

    Faculty:  Lydia Zablotska

    Location:      Mission Hall 1407

    • Session Slides:

    • Week 8 - Test your knowledge of confounding File
    • Week 8 - Confounding File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      RGL2008 Ch 9 (pp 129-134)
      RGL2008 Ch 12
      RGL2008 Ch 15

    • Recommended Reading:

      R2012 Ch 10

      H&R 2015 Ch 7

    • Kurth et al 2005 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • Hernan et al 2002 File
      Not available unless: Your ID number contains 02
    • Weng and Hertz-picciotto 2009 File
      Not available unless: Your ID number contains 02
    • Howards Use of DAGs and causality AJE 2012 File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (access restricted to registered students):

  • Friday, March 4, 2016; 1:30 PM - 4:30 PM

    Lecture: Interaction and effect-measure modification I

    Biological vs. statistical; multiplicative and additive; evaluation of interaction, presentation of results.

    Faculty:  Lydia Zablotska

    Location:      Mission Hall 1407

    • Session Slides:

    • Week 9 slides File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Theoretical and Conceptual Frameworks

    • Knol et al 2007 File
      Not available unless: Your ID number contains 02
    • VanderWeele Vansteelandt AJE 2014 File
      Not available unless: Your ID number contains 02
    • Zhang Am. J. Epidemiol. 2011 File
      Not available unless: Your ID number contains 02
    • VanderWeele-396-9 AJE mechanisticIx File
      Not available unless: Your ID number contains 02
    • Knol VanderWeele Int. J. Epidemiol. 2012 File
      Not available unless: Your ID number contains 02

    • Write-up on Relative Excess Risk Due to Interaction:

    • RERI calculations rev File
      Not available unless: Your ID number contains 02

    • Required Reading:

      RGL2008 Ch 5
      RGL2008 Ch 16

    • Recommended Reading:

      R2012 Ch 11

      H&R2015 Chs 4-5

    • HR Ch 4-5 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • Turner et al Am. J. Epidemiol. 2014 File
      Not available unless: Your ID number contains 02
    • Panagiotou and Wacholder Am. J. Epidemiol. 2014 File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (access restricted to registered students):

  • Friday, March 11, 2016; 1:30 PM - 4:30 PM

    Lecture: Interaction and effect-measure modification II

    Assessment of multiplicative and additive interaction for various types of data, presentation of results of studies with interaction

    Faculty:  Lydia Zablotska


    Location:      Mission Hall 1407

    • Session Slides:

    • Week 10 slides File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Theoretical and Conceptual Frameworks

    • Zhang Am. J. Epidemiol. 2011 File
      Not available unless: Your ID number contains 02
    • VanderWeele Vansteelandt AJE 2014 File
      Not available unless: Your ID number contains 02
    • VanderWeele-396-9 AJE mechanisticIx File
      Not available unless: Your ID number contains 02
    • Knol et al 2007 File
      Not available unless: Your ID number contains 02
    • Knol VanderWeele Int. J. Epidemiol. 2012 File
      Not available unless: Your ID number contains 02

    • Write-up on Relative Excess Risk Due to Interaction:

    • RERI calculations rev File
      Not available unless: Your ID number contains 02

    • Required Reading:

      VW 2015 Ch 9-10

    • VW Ch 9-10 File
      Not available unless: Your ID number contains 02

    • Discussion section readings and homework assignments:

    • delta method File
    • Interaction File

    • Assignment Answer Key (access restricted to registered students):