EPI 252: Cancer Epidemiology (Winter 2016)
Section outline
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Lecture: Brief history of cancer epidemiology, cancer control and prevention (Bob Hiatt)
Lecture: Overview of what is known about major cancers and major causes (Catherine Metayer)
History: Brief history up to 1981 Doll and Peto report. Overview of major cancers and causes & cancer surveillance
Faculty: Robert Hiatt and Catherine Metayer
Location: Mission Hall 2105-
EPI252 PH258 Syllabus_Updated 2/11/16 File
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EPI252Introducton010616 File
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EPI252Surveillance010116 File
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Kohler, BA., Sherman, RL., Howlander, N., et al., Annual Report to the Nation on the Status of Cancer, 1975–2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State. J Natl Cancer Inst. 2015 Mar 30;107(6):djv048. File
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Hiatt, RA., Tai, CG. Blayney, DW., et al., Leveraging State Cancer Registries to Measure and Improve the Quality of Cancer Care: A Potential Strategy for California and Beyond. J Natl Cancer Inst. 2015 Mar 11;107(5). pii: djv047. File
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Hiatt, RA., The future of cancer surveillance. Cancer Causes Control. 2006 Jun;17(5):639-46. File
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Lecture: Genetic susceptibility and cancer (John Witte)
Lecture: Epigenetic mechanism and cancer risk (Joe Wiemels)
Faculty: John Witte/Joseph Wiemels
Location: Mission Hall 2105-
2016 Cancer Epi J. Witte File
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Epigenetics lecture Cancer Epi 2016 File
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Admixture mapping YihsuanWu File
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Winkler, CA., Nelson, GW., Smith, MW., Admixture Mapping Comes of Age. Annu Rev Genomics Hum Genet. 2010;11:65-89. File
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Hutter, CM., Mechanic, LE., Chatterjee, N., Kraft, P., Gillanders, EM., NCI Gene-Environment Think Tank., Gene-Environment Interactions in Cancer Epidemiology: A National Cancer Institute Think Tank Report. Genet Epidemiol. 2013 Nov;37(7):643-57. File
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Witte, JS., Genome-wide Association Studies and Beyond. Annu Rev Public Health. 2010;31:9-20. File
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Osborne-Majnik, A., Fu, Q., Lane, RH., Epigenetic Mechanisms in Fetal Origins of Health and Disease. Clin Obstet Gynecol. 2013 Sep;56(3):622-32. File
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Richmond, RC., Simpkin, AJ., et al., Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Hum Mol Genet. 2015 Apr 15;24(8):2201-17. File
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Ladd-Acosta, C., Epigenetic Signatures as Biomarkers of Exposure. Curr Environ Health Rep. 2015 Jun;2(2):117-25. File
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Van Veldhoven, K., Rahman, S., Vineis, P., Epigenetics and Epidemiology: Models of Study and Examples. Cancer Treat Res. 2014;159:241-55. File
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Brennan, P., Commentary: Mendelian randomization andgene–environment interaction. Int J Epidemiol. 2004; 33:17–21 File
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Lecture: Cancers in children and adolescents (Catherine Metayer)
Faculty: Catherine Metayer
Location: Mission Hall 2105-
Metayer ChidhoodCancer PH258(2016)v2 File
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Bonaventure, A., Simpson, J., Ansell, P., Roman, E., Lightfoot, T., Prescription drug use during pregnancy and risk of childhood cancer – Is there an association? Cancer Epidemiol. 2015 Feb;39(1):73-8. File
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Filippini, T., Heck JE., Malagoli C., Del Giovane, C., Vinceti, M., A Review and Meta-Analysis of Outdoor Air Pollution and Risk of Childhood Leukemia. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2015;33(1):36-66. File
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Lecture: Tobacco and lung cancer: a historical perspective and determining causality in cancer epidemiology (Bob Hiatt)
Faculty: Robert Hiatt
Location: Mission Hall 2105-
Doll, R., Hill, AB., Lung cancer and other causes of death in relation to smoking; a second report on the mortality of British doctors. Br Med J. 1956 Nov 10;2(5001):1071-81. File
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Wynder, E.L. and E.A. Graham, Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. J Am Med Assoc, 1950. 143(4): p. 329-36. File
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Hill, AB., The Environment and Disease: Association or Causation? Proc R Soc Med. 1965 May; 58(5): 295–300. File
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Mukherjee, S., The Emperor of All Maladies: A Biography of Cancer2011: Scribner. File
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Glantz, SA., Johnson, KC., The surgeon general report on smoking and health 50 years later: breast cancer and the cost of increasing caution. Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):37-46. File
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Kalkhoran, S., Glantz, SA., E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis. Lancet Respir Med. 2016 Jan 13. pii: S2213-2600(15)00521-4. File
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USDHHS, The Health Consequences of Smoking - 50 years of Progress: A Report of the Surgeon General, U.S.D.o.H.a.H. Services, Editor 2014 File
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Tan, CE., Glantz, SA., Association between smoke-free legislation and hospitalizations for cardiac, cerebrovascular, and respiratory diseases: a meta-analysis. Circulation. 2012 Oct 30;126(18):2177-83. File
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Johnson, KC., Miller, AB., Collishaw, NE.,et al., Active smoking and secondhand smoke increase breast cancer risk: the report of the Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk (2009). Tob Control. 2011 Jan;20(1):e2. File
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Lecture: Molecular and cellular basis of cancer (Thea Tlsty)
Faculty: Thea Tlsty
Location: Mission Hall 2105
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Thea Tlsty Lecture EPI 252 2016 File
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Hanahan, D. Weinberg, RA., Hallmarks of Cancer: The next Generation. Cell. 2011 Mar 4;144(5):646-74. File
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Weaver, VM., et al., Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies. J Cell Biol. 1997 Apr 7;137(1):231-45. File
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Sonnenschein, C, Soto, AM, The aging of the 2000 and 2011 Hallmarks of Cancer reviews: A critique. J. Biosci. 38(3), September 2013, 651-663. File
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Lecture: Ionizing radiation and cancer (Lydia Zablotska)
Faculty: Lydia Zablotska
Location: Mission Hall 2105
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Radiation and health UCBerkeley March 10, 2016 File
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Zablotska, LB., Lane, RS., Thompson, PA., A reanalysis of cancer mortality in Canadian nuclear workers (1956–1994) based on revised exposure and cohort data. Br J Cancer, 2014. Jan 7;110(1):214-23. File
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Cardis, E., Vrijheid, M., Blettner, M., et al., Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries. BMJ. 2005. Jul 9;331(7508):77. Epub 2005 Jun 29. File
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Miglioretti DL., Johnson E., Williams, A., et al., The Use of Computed Tomography in Pediatrics and the Associated Radiation Exposure and Estimated Cancer Risk. JAMA Pediatr. 2013 Aug 1;167(8):700-7. File
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Brambilla, M., De Mauri, A., Leva, L., Carriero, A., Picano, E., Cumulative radiation dose from medical imaging in chronic adult patients. Am J Med. 2013 Jun;126(6):480-6. File
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Lecture: Methodological considerations in nutrition and cancer / Nutrition and cancer (Erin Van Blarigan)
Faculty: Erin Van Blarigan
Location: Mission Hall 2105
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Nutrition and Cancer File
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Hanyuda, A., Kim, SA., et al., Survival benefit of exercise differs by tumor IRS1 expression status in colorectal cancer. Ann Surg Oncol. 2015 Nov 17. [Epub ahead of print] File
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Gaziano, JM., Sesso, HD., et al., Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2012 Nov 14;308(18):1871-80. File
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Chen, WY., Rosner, B., et al. Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA. 2011 Nov 2;306(17):1884-90. File
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Klein, EA., Thompson Jr, IM., et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011 Oct 12;306(14):1549-56. File
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Torfadottir, JE.,Steingrimsdottir, L., et al. Milk intake in early life and risk of advanced prostate cancer. Am J Epidemiol. 2012 Jan 15;175(2):144-53. File
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"Injustice and Health” UCSF Teach-in with Soledad O'Brien
Presenter: Soledad O'Brien
Location: Cole Hall Auditorium, 513 Parnassus Avenue
UC San Francisco is pleased to facilitate this inter-professional educational event that will engage our nation’s future health science leaders on issues of racism, discrimination, Islamophobia and health care disparities.
Sponsors: Offices of the Chancellor, Executive Vice Chancellor and Provost and Diversity and Outreach
Registration is required. Please print your tickets.
To Register: https://www.eventbrite.com/e/injustice-and-health-ucsf-teach-in-with-soledad-obrien-tickets-21020417635
Schedule of Events
11:30AM Doors Open
12:00PM Keynote with Soledad O’Brien
1:30PM UCSF Panel with Soledad O’Brien
*Lunch provided while supplies last.
This event will be live-streamed at the following locations or can be viewed at your desk.
Laurel Heights, Laurel Heights Auditorium
Mission Bay, Rock Hall Pottruck Auditorium
Parnassus, Toland Hall
Zuckerberg San Francisco General Hospital, Carr Auditorium
Join the conversation on Twitter! #ucsfTeachin @ucsfodo
If you require accommodations for full access to this event or have accommodation related questions, please contact DiversityOutreach@ucsf.edu.
Wednesday, February 24 at 12:00pm
Cole Hall Auditorium
513 Parnassus Avenue, San Francisco, California 94143 -
Lecture: Brain Tumors (Kyle Walsh)
Faculty: Kyle Walsh
Location: Mission Hall 2109-
BerkeleyCancerEpi BrainTumors 2016 File
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Walsh, KM., Anderson, E., Hansen, HM., et al., Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies. Genet Epidemiol. 2013 Feb;37(2):222-8. File
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Walsh, KM., Codd, V., Smirnov, IV., et al., Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul;46(7):731-5. File
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Molinaro, AM., Wrensch, MR., Jenkins, RB., Eckel-Passow, JE., Statistical considerations on prognostic models for glioma. Neuro Oncol. 2015 Dec 8. pii: nov255. [Epub ahead of print] File
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Lecture: Cancer attributable to infectious agents and the role of the microbiome in cancer (Lee Riley)
Faculty: Lee Riley
Location: Mission Hall 2105
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Infectious causes of cancer 2016 File
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Alibek, K., Mussabekova, A., Kakpenova, A., Duisembekova, A., Baiken, Y., Aituov, B., Karatayeva, N., Zhussupbekova, S., Childhood cancers: what is a possible role of infectious agents? Infect Agent Cancer. 2013 Dec 10;8(1):48. File
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Schwabe, RF., Jobin, C., The microbiome and cancer. Nat Rev Cancer. 2013 November ; 13(11): 800–812. File
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de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., Plummer, M., Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012 Jun;13(6):607-15. File
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De Flora, S., La Maestra, S., Epidemiology of cancers of infectious origin and prevention strategies. J Prev Med Hyg. 2015 Jun 10;56(1):E15-20. File
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Lecture: Breast cancer screening controversies (Karla Kerlikowski)
Lecture: The guideline decision process of the USPSTF (Kristen Bibbins-Domingo)
Faculty: Karla Kerlikowski and Kristen Bibbins-Domingo
Location: Mission Hall 2105
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K. Bibbins Domingo PPT File
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Oeffinger, KC., et al., Breast Cancer Screening for Women at Average Risk 2015 Guideline Update From the American Cancer Society. JAMA. 2015;314(15):1599-1614. File
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Nelson, HD., et al., Effectiveness of Breast Cancer Screening: Systematic Review and Meta-analysis to Update the 2009 U.S. Preventive Services Task Force Recommendation. Ann Intern Med. 151.10 (2009): 727–W242. PMC. Web. 2 Feb. 2016. File
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Mandelblatt, JS., et al., Collaborative Modeling of the Benefits and Harms Associated With Different U.S. Breast Cancer Screening Strategies. Ann Intern Med. Published online 12 January 2016 doi:10.7326/M15-1536. File
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Schousboe, JT., Kerlikowske, K., Loh, A., Cummings, S., Personalizing Mammography by Breast Density and Other Risk Factors for Breast Cancer: Analysis of Health Benefits and Cost-Effectiveness. Ann Intern Med. 2011 Jul 5;155(1):10-20. File
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Siu, AL., Bibbins-Domingo, K., Grossman, DC., LeFevre, ML.; U.S. Preventive Services Task Force., Convergence and Divergence Around Breast Cancer Screening. Ann Intern Med. 2016 Feb 16;164(4):301-2. File
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Nelson, HD., Fu, R., Cantor, A., Pappas, M., et al., Effectiveness of Breast Cancer Screening: Systematic Review and Meta-analysis to Update the 2009 U.S. Preventive Services Task Force Recommendation. Ann Intern Med. 2016 Feb 16;164(4):244-55. File
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Siu, AL.; U.S. Preventive Services Task Force., Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med. 2016 Feb 16;164(4):279-96. File
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Mandelblatt, JS., Stout, NK., Schechter, CB., et al., Collaborative Modeling of the Benefits and Harms Associated With Different U.S. Breast Cancer Screening Strategies. Ann Intern Med. 2016 Feb 16;164(4):215-25. File
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Student Presentations
Faculty: Robert Hiatt and Catherine Metayer
Location: Mission Hall 2109
