Section outline

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  • Wednesday, August 1, 2018, 9:00 AM - 10:15 AM

    Lecture: The Research Question

    Introduction to the course; components ("anatomy") of a research protocol and "physiology" of research; examples from course faculty research.

    Faculty: Peter Chin-Hong and Miriam Kuppermann

    Location:      HSW 302 

  • Wednesday, August 1, 2018, 10:30 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty: Felica Chow, Asa Clemenzi-Allen, Beth Cohen, Jennifer Felder, Samuel Goldman, Diana Kwong, Brett Ley, Kala Metha, Amy Padula, Neela Penumarthy, Daniel West

    Location:   Chow S-159, Clemenzi-Allen online, Cohen S-163, Cullaro S-172, Felder U-506, Goldman S176, Kwong S-174, Ley S-180, Metha S-168, Padula U-456,  Penumarthy U70,  West S-157

    • Assignment:

      Download and review full assignment below. Most important:

        1. Read Chapters 1 & 2 of DCR-4
        2. Choose a research question.
        3. Identify and meet with your mentor
        4. Bring a hard copy of a 1-sentence version of your Research Question and a 1/2 to 3/4 page Significance section to class.
        5. Use a citation management program for the references. Take a class if needed.

    • Assignment Due Date:

      Assignment 1, to be completed before August 2


    • ASSIGNMENT ONE 2018.dueWeekOne File

  • Monday, August 6, 2018, 9:00 AM - 10:15 AM

    Lecture: Subjects and variables

    Target and accessibile populations; inclusion and exclusion criteria; balancing feasibility and generalizability; sampling; types of variables and measurements; and maximizing precision and accuracy.

    Faculty:  Beth Cohen
     
    Location:      HSW-302

    • Session Slides:

    • DCR Subjects Measurements 2018 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Subjects and Variables lecture URL
      Not available unless: You belong to Registered Students Only

    • Required Reading:

      DCR-4 Chapter 3: Choosing the Study Subjects

      DCR-4 Chapter 4: Planning the Measurements

    • How do we know what we know? This is a 52 minute recorded lecture by Tom Newman URL
      Not available unless: Your ID number contains 02

    • Optional Reading:

  • Monday, August 6, 2018, 10:30 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty: Felica Chow, Asa Clemenzi-Allen, Beth Cohen, Jennifer Felder, Samuel Goldman, Diana Kwong, Brett Ley, Kala Metha, Amy Padula, Neela Penumarthy, Daniel West

    Location:   Chow S-159, Clemenzi-Allen online, Cohen S-163, Cullaro S-172, Felder U-506, Goldman U458, Kwong S-174, Ley S-180, Metha S-168, Padula U-456,  Penumarthy U70,  West S-157


    • Assignment:

      Download and review full assignment below. Most important:

        1. Read chapters 3 and 4 of DCR-4.
        2. Compose an outline of your study.
        3. Include a more detailed "Study Subjects" and “Variables” section.
        4. Make an appointment to meet with your mentor.
        5. Watch TN's presentation "How do we know what we know?"

    • Assignment Due Date:  

      Assignment 2 (Part I) due in small group on Monday, August 6, written due to small group instructor by noon on Thursday, August 9.

    • ASSIGNMENT TWO (PART 1) 2018.dueWeekTwo.080617 File

  • Wednesday, August 8, 2018; 9:00 AM - 10:15 AM

    Lecture: Study Designs

    Faculty:  Kirsten Bibbins-Domingo

    Location:      HSW 302

    • Session Slides:

    • KBD DCR Lecture Slides 2018 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Study Design Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 7: Designing Cross-Sectional and Cohort Studies

      DCR-4 Chapter 8: Designing Case-Control Studies

    • Optional Reading:

  • Wednesday, August 8, 2018, 10:30 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty: Felica Chow, Asa Clemenzi-Allen, Beth Cohen, Jennifer Felder, Samuel Goldman, Diana Kwong, Brett Ley, Kala Metha, Amy Padula, Neela Penumarthy, Daniel West

    Location:   Chow S-159, Clemenzi-Allen online, Cohen S-163, Cullaro S-172, Felder U-506, Goldman S178, Kwong S-174, Ley S-180, Metha S-168, Padula U-456,  Penumarthy U70,  West S-157


    • Assignment:

              Download and review full assignment below. Most important:

        1. Read Chapters 7 and 8 of DCR-4 (and either 12,13 or 18 depending on your study).
        2. Have a clear, detailed understanding of exactly how at least one predictor and one outcome variable for your study will be (or was) measured
        3. Have experience providing tips to colleagues
        4. Be able to list and explain the advantages and disadvantages of basic observational study designs, including case-control, cross-sectional and cohort studies
        5. Understand simple statistics and the application to each of your studies

    • Assignment Due Date:

      Assignment 2 (Part 2) due in small group on Wednesday, August 8, written due to small group instructor by noon on Thursday, August 9.

    • ASSIGNMENT TWO (PART 2) 2018.due WeekTwo.080818 File

  • Monday, August 13, 2018, 9:00 AM - 10:15 AM

    Lecture: Sample Size

    An introduction to the concepts and information needed to estimate sample sizes for various types of studies.  It includes suggestions for making more affordably sized studies

    Faculty: Michael Kohn

    Location:  HSW 302

    • Session Slides:

    • DCR Sample Size Kohn Updated 2018.0813 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Sample Size Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapters 5 and 6

  • Monday, August 13, 2018, 10:30 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty: Felica Chow, Asa Clemenzi-Allen, Beth Cohen, Jennifer Felder, Samuel Goldman, Diana Kwong, Brett Ley, Kala Metha, Amy Padula, Neela Penumarthy, Daniel West

    Location:   Chow S-159, Clemenzi-Allen online, Cohen S-163, Cullaro S-172, Felder U-506, Goldman U460, Kwong S-174, Ley S-180, Metha S-168, Padula U-456,  Penumarthy U70,  West S-157


    • Assignment:

       Download and review full assignment below. Most important:

        1. Provide a contrasting point of view to the traditional view that studies with <80% power are not worthwhile
        2. Be very comfortable with the 1-sentence study plan summary
        3. Have justified the decisions/assumptions you used to estimate your sample size
        4. Know how to use a sample size calculator and the tables in the book to estimate sample size, given the decisions and assumptions you justified
        5. Be able to propose a logical (if not feasible) alternative design for your research question

    • Assignment Due Date:  

      Assignment 3 (Part 1) due in small group on Monday, August 13, due electronically to small group instructor by noon on Thursday, August 16.

    • ASSIGNMENT THREE (PARTS 1 and 2) 2018.dueWeekThree.081618 File

  • Wednesday, August 15, 2018; 9:00 AM - 10:15 AM

    Lecture: Causality/Clinical Trials 

    Drawing causal inference; chance, bias, and confounding: pros and cons of observational studies and randomized controlled trials; examples from the diabetes literature

    Faculty: Deborah Grady
     
    Location:  HSW 302

    • Session Slides:

    • Causal Inference 2018 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Causality Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 9: Enhancing Causal Inference in Observational Studies

      DCR-4 Chapter 10:  Designing a Randomized Blinded Trial

      DCR-4 Chapter 11: Alternative Trial Designs and Implementation Issues

  • Wednesday, August 15, 2018, 10:30 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty: Felica Chow, Asa Clemenzi-Allen, Beth Cohen, Jennifer Felder, Samuel Goldman, Diana Kwong, Brett Ley, Kala Metha, Amy Padula, Neela Penumarthy, Daniel West

    Location:   Chow S-159, Clemenzi-Allen online, Cohen S-163, Cullaro S-172, Felder U-506, Goldman U458, Kwong S-174, Ley S-180, Metha S-168, Padula U-456,  Penumarthy U70,  West S-157

    • Assignment:

      Download and review full assignment below.  Most important:

      1.     Read chapters 9, 10 and 11

      2.     Be very comfortable with the 1-sentence study plan summary

      3.     Have experience providing tips to colleagues

      4.     Be able to propose a logical (if not feasible) alternative design for your research question

        

    • ASSIGNMENT THREE (PARTS 1 and 2) 2018.dueWeekThree.081618 File

    • Assignment Due Date: 

      Assignment 3 (Part 2) due in small group on Wednesday, August 15, due electronically to small group instructor by noon on Thursday, August 16.

  • Monday, August 20, 2018; 9:00 AM - 10:15 AM

    Lecture: Questionnaires and qualitative methods

    Development of questionnaires; adapting existing instruments or items vs creating new ones; pretesting to identify ambiguities.

    Faculty:  Miriam Kuppermann

    Location:      HSW 302

    • Session Slides:

    • Kuppermann DCR 082018v2 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Questionnaires and Qualitative Methods Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 15: Designing Questionnaires and Interviews

      DCR-4 Chapter 16: Data Management

  • Monday, August 20, 2018, 10:30 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty: Felica Chow, Asa Clemenzi-Allen, Beth Cohen, Jennifer Felder, Samuel Goldman, Diana Kwong, Brett Ley, Kala Metha, Amy Padula, Neela Penumarthy, Daniel West

    Location:   Chow S-159, Clemenzi-Allen online, Cohen S-163, Cullaro S-172, Felder U-506, Goldman S176, Kwong S-174, Ley S-180, Metha S-168, Padula U-456,  Penumarthy U70,  West S-157


    • Assignment:

              Download and review full assignment below. Most important:

        1. Provide a contrasting point of view to the traditional view that studies with <80% power are not worthwhile
        2. Be very comfortable with the 1-sentence study plan summary
        3. Have justified the decisions/assumptions you used to estimate your sample size
        4. Know how to use a sample size calculator and the tables in the book to estimate sample size, given the decisions and assumptions you justified

  • Wednesday, August 22, 2018, 9:00 AM - 10:15 AM

    Lecture: Introduction to Statistics

    Biostatistic pearls.  How to interpret P values, Standard error versus Standard deviation.  Confidence intervals.  Adjustment in multivariable analyses.
     
    Faculty:  Charles McCulloch
     
    Location:      HSW 302

    • Session Slides:

    • DCR lecture biostat 2018 handouts File
    • DCR lecture biostat 2018 handouts File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Introduction to Statistics Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 5: Underlying Statistical Principles (starting on page 46).

  • Wednesday, August 22, 2018, 10:30 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty: Felica Chow, Asa Clemenzi-Allen, Beth Cohen, Jennifer Felder, Samuel Goldman, Diana Kwong, Brett Ley, Kala Metha, Amy Padula, Neela Penumarthy, Daniel West

    Location:   Chow S-159, Clemenzi-Allen online, Cohen S-163, Cullaro S-172, Felder U-506, Goldman S176, Kwong S-174, Ley S-180, Metha S-168, Padula U-456,  Penumarthy U70,  West S-157


  • Monday August 27, 2018; 9:00 AM - 10:15 AM

    Protocol Peer Review

    Faculty:  TBA

    Location:  varied, TBA