Course: BIOSTAT 208: Biostatistical Methods for Clinical Research II (Winter 2014)

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Biostatistical Methods for Clinical Research II BIOSTAT 208 Winter 2014 (3 units) . Course Director: Steve Shiboski, PhD . Professor, Department of Epidemiology & Biostatistics

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Select section Tuesday, January 7, 2014; 10:30 AM – 12:00 PM

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Tuesday, January 7, 2014; 10:30 AM – 12:00 PM
Lecture: Introduction to Regression Modeling

Class organization; regression overview; review of simple linear regression

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: Chap. 2, Section 3.3, VGSM
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Select section Thursday, January 9, 2014; 10:30 AM – 12:30 PM

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Thursday, January 9, 2014; 10:30 AM – 12:30 PM
Computer Lab: Introduction

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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Select section Tuesday, January 14, 2014; 10:30 AM – 12:00 PM

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Tuesday, January 14, 2014; 10:30 AM – 12:00 PM
Lecture: Multiple Linear Regression

Regression with a single binary or continuous predictor; Multiple regression

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: Sections 4.1-4.2, VGSM
Select section Thursday, January 16, 2014; 10:30 AM – 12:30 PM

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Thursday, January 16, 2014; 10:30 AM – 12:30 PM
Computer Lab: Multiple Linear Regression

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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Select section Tuesday, January 21, 2014; 10:30 AM – 12:00 PM

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Tuesday, January 21, 2014; 10:30 AM – 12:00 PM
Lecture: Categorical Predictors; Log Transformations of Predictors & Outcome

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: Section 4.3 & 4.7.5, VGSM
Select section Thursday, January 23, 2014; 10:30 AM – 12:30 PM

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Thursday, January 23, 2014; 10:30 AM – 12:30 PM
Computer Lab: Categorical Predictors

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski 6702, Poirot CB 6704
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Select section Tuesday, January 28, 2014; 10:30 AM – 12:00 PM

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Tuesday, January 28, 2014; 10:30 AM – 12:00 PM
Lecture: Confounding and Mediation

Using regression to control for confounding and assess mediation

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: Sections 4.4-4.5, VGSM
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  Optional Reading: Review lectures on confounding and stratified analysis from the Epidemiologic Methods course (Epi 203 -slides available on course web site for dates 11/12/13, 11/19/13 & 11/26/13)
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Select section Tuesday, January 28, 2014; 12:00 PM – 12:50 PM

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Tuesday, January 28, 2014; 12:00 PM – 12:50 PM
Homework Sessions

Faculty: Steve Shiboski

Location: CB 6702
Select section Thursday, January 30, 2014; 10:30 AM – 12:30 PM

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Thursday, January 30, 2014; 10:30 AM – 12:30 PM
Computer Lab: Confounding and Mediation

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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Select section Tuesday, February 4, 2014; 10:30 AM – 12:00 PM

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Tuesday, February 4, 2014; 10:30 AM – 12:00 PM
Lecture: Interaction
Conceptual introduction, product terms, testing for interactions, lincom statements

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: Sections 4.6, VGSM
Select section Thursday, February 6, 2014; 10:30 AM – 12:30 PM

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Thursday, February 6, 2014; 10:30 AM – 12:30 PM
Computer Lab: Interaction

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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Select section Tuesday, February 11, 2014; 10:30 AM – 12:00 PM

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Tuesday, February 11, 2014; 10:30 AM – 12:00 PM
Lecture: Model Diagnostics
Linearity, normality, constant variance; influential points

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: Section 4.7, VGSM
Select section Thursday, February 13, 2014; 10:30 AM – 12:30 PM

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Thursday, February 13, 2014; 10:30 AM – 12:30 PM
Computer Lab: Model Diagnostics
Causal diagrams, three inferential goals; number of predictors, colinearity

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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Select section Tuesday, February 18, 2014; 10:30 AM – 12:00 PM

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Tuesday, February 18, 2014; 10:30 AM – 12:00 PM
Lecture: Predictor Selection

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: VGSM - Chapter 10
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Select section Tuesday, February 18, 2014; 12:00 PM – 12:50 PM

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Tuesday, February 18, 2014; 12:00 PM – 12:50 PM
Homework Discussion - HW #2

Faculty: Steve Shiboski

Location: China Basin 6702
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  Final Exam Due Date: Due (date) at (time, i.e. “1pm”,” at the beginning of Small Group Section”)
Select section Thursday, February 20, 2014; 10:30 AM – 12:30 PM

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Thursday, February 20, 2014; 10:30 AM – 12:30 PM
Computer Lab: Predictor Selection

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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  Change in coefficient help file (cic.hlp)
Select section Tuesday, February 25, 2014; 10:30 AM – 12:00 PM

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Tuesday, February 25, 2014; 10:30 AM – 12:00 PM
Lecture: Binary Outcome Data

Contingency tables; binary outcomes; measures of association; logistic model

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: VGSM Section 5.1
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  Assignment Due Date: March 11, 2014
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Select section Tuesday, February 25, 2014; 12:00 PM – 12:50 PM

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Tuesday, February 25, 2014; 12:00 PM – 12:50 PM
Homework Session

Faculty: Steve Shiboski

Location: China Basin 6702
Select section Thursday, February 27, 2014; 10:30 AM – 12:30 PM

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Thursday, February 27, 2014; 10:30 AM – 12:30 PM
Computer Lab: Binary Outcome Data

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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Select section Tuesday, March 4, 2014; 10:30 AM – 12:00 PM

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Tuesday, March 4, 2014; 10:30 AM – 12:00 PM
Lecture: Multiple Logistic Regression
Multiple logistic regression; confounding; interaction

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: VGSM Section 5.2 (intro. & sections 5.2.1-5.2.4)
Select section Thursday, March 6, 2014; 10:30 AM – 12:30 PM

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Thursday, March 6, 2014; 10:30 AM – 12:30 PM
Computer Lab: Multiple Logistic Regression

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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Select section Tuesday, March 11, 2014; 10:30 AM – 12:00 PM

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Tuesday, March 11, 2014; 10:30 AM – 12:00 PM
Lecture: Prediction and Model Diagnostics
Prediction; model assessment; outliers; goodness of fit

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: VGSM Sections 5.2.5-5.2.6 & 5.4
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  Final Exam Due Date: Due Friday, March 21 by 2:00 PM
Select section Tuesday, March 11, 2014; 12:00 PM – 12:50 PM

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Tuesday, March 11, 2014; 12:00 PM – 12:50 PM
Homework Session

Faculty: Steve Shiboski

Location: China Basin 6702
Select section Thursday, March 13, 2014; 10:30 AM – 12:30 PM

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Thursday, March 13, 2014; 10:30 AM – 12:30 PM
Computer lab: Prediction and Model Diagnostics

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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  Final Exam Due Date: Due (date) at (time, i.e. “1pm”,” at the beginning of Small Group Section”)
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Select section Tuesday, March 18, 2014; 10:30 AM – 12:00 PM

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Tuesday, March 18, 2014; 10:30 AM – 12:00 PM
Lecture: Case Control Studies

Case-control study; conditional logistic regression; generalized linear models

Faculty: Steve Shiboski

Location: China Basin 6702
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  Required Reading: VGSM Sections 5.3 & 5.5
Select section Thursday, March 20, 2014; 10:30 AM – 12:30 PM

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Thursday, March 20, 2014; 10:30 AM – 12:30 PM
Computer Lab: Case Control Studies

Faculty: Steve Shiboski, Eugenie Poirot

Location: Shiboski CB 6702, Poirot CB 6704
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  Assignment: Note: the lab assignment will be posted this week, but attendance is optional
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