Course: BIOSTAT 209: Biostatistical Methods for Clinical Research III (Spring 2014)

Section outline

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Biostatistical Methods In Clinical Research III BIOSTAT209 Spring 2014 (3 units) . Course Director: John Kornak, PhD . Associate Professor, Department of Epidemiology and Biostatistics

Select section Tuesday, April 1, 2014; 10:30 AM - 12:00 PM

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Tuesday, April 1, 2014; 10:30 AM - 12:00 PM
Lecture: Survival data
Survival data, hazards functions, hazard ratios, basics of the Cox model.

Faculty: John Kornak

Location: China Basin 6702
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  Session Slides:
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  lectureS1 File
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  lectureS1 File
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  lectureS1 6slidesPerSheet File
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  Session Audio/Video Recording (Access restricted to registered students):
- Select activity Required Reading: Useful to review Chapter 3.5 in...
  
  Required Reading:
  
  Useful to review Chapter 3.5 in advance
  
  Chapters 6.1-6.2.4, VGSM
- Select activity biostat 209 duedates-14
  
  biostat 209 duedates-14 File
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  biostat 209 overview-14 File
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  ProjectGuidelinesFor2014 File
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  ProjectGuidelinesFor2014mainPoints File
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  Assignment:
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  survhw1 File
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  survhw1 File
- Select activity Assignment Due Date: April 15, 2014
  
  Assignment Due Date: April 15, 2014
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  Datasets:
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  actg019 File
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  pbc File
Select section Thursday, April 3, 2014; 10:30 AM - 12:30 PM

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Thursday, April 3, 2014; 10:30 AM - 12:30 PM
Computer Lab: Survival analysis data

Faculty: Barbara Grimes, John Kornak

Location: Kornak CB 6702. Grimes CB 6704
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  Assignment:
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  labS1 File
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  labS1 File
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  larynx M File
Select section Tuesday, April 8, 2014; 10:30 AM - 12:00 PM

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Tuesday, April 8, 2014; 10:30 AM - 12:00 PM
Lecture: Survival data
Cox model with binary, categorical and continuous predictors; confounding, mediation and interaction; adjusted survival curves.

Faculty: John Kornak

Location: China Basin 6702
- Select activity Session Slides:
  
  Session Slides:
- Select activity lectureS2
  
  lectureS2 File
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  lectureS2 File
- Select activity lectureS2 6slidesPerSheet
  
  lectureS2 6slidesPerSheet File
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  Session Audio/Video Recording (Access restricted to registered students):
- Select activity Required Reading: Chapters 6.2.5-6.2.13, VGSM
  
  Required Reading:
  
  Chapters 6.2.5-6.2.13, VGSM
- Select activity Assignment:
  
  Assignment:
- Select activity survhw2
  
  survhw2 File
- Select activity survhw2
  
  survhw2 File
- Select activity Assignment Due Date: April 22, 2014
  
  Assignment Due Date: April 22, 2014
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- Select activity pbc
  
  pbc File
Select section Thursday, April 10, 2014; 10:30 AM - 12:30 PM

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Thursday, April 10, 2014; 10:30 AM - 12:30 PM
Computer Lab: Survival analysis data

Faculty: Barbara Grimes, John Kornak

Location: Kornak CB 6702. Grimes CB 6704
- Select activity Assignment: Optional narrative description
  
  Assignment: Optional narrative description
- Select activity labS2
  
  labS2 File
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  labS2 File
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  Datasets:
- Select activity pbc
  
  pbc File
Select section Tuesday, April 15, 2014; 10:30 AM - 12:00 PM

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Tuesday, April 15, 2014; 10:30 AM - 12:00 PM
Lecture: Survival Data
Extensions and Diagnostics for the Cox Model: time dependent covariates; stratified Cox model; model checking for the Cox model.

Faculty: John Kornak

Location: China Basin 6702
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  Session Slides:
- Select activity lectureS3
  
  lectureS3 File
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  lectureS3 File
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  lectureS3 6slidesPerSheet File
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  Session Audio/Video Recording (Access restricted to registered students):
- Select activity Required Reading: Chapters 6.3-6.5, VGSM
  
  Required Reading:
  
  Chapters 6.3-6.5, VGSM
Select section Tuesday, April 15, 2014; 12:00 PM - 1:00 PM

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Tuesday, April 15, 2014; 12:00 PM - 1:00 PM
Homework Session

Faculty: John Kornak

Location: China Basin 6702
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  Assignment Answer Key (Access restricted to registered students):
Select section Thursday, April 17, 2014; 10:30 AM - 12:30 PM

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Thursday, April 17, 2014; 10:30 AM - 12:30 PM
Computer Lab: Survival analysis data

Faculty: Barbara Grimes, John Kornak

Location: Kornak CB 6702. Grimes CB 6704
- Select activity Assignment: Optional narrative description
  
  Assignment: Optional narrative description
- Select activity labS3
  
  labS3 File
- Select activity labS3
  
  labS3 File
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  Datasets:
- Select activity lab3-actg019 a
  
  lab3-actg019 a File
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  lab3-pbc a File
Select section Tuesday, April 22, 2014; 10:30 AM - 12:00 PM

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Tuesday, April 22, 2014; 10:30 AM - 12:00 PM
Lecture: Common biostatistical problems
Misinterpretation of p-values; estimates and confidence intervals; accuracy versus conservatism.

Faculty: John Kornak

Location: China Basin 6702
- Select activity Session Slides:
  
  Session Slides:
- Select activity Biostat problems lecture14annotated
  
  Biostat problems lecture14annotated File
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  Biostat problems lecture14annotated File
- Select activity Biostat problems lecture14
  
  Biostat problems lecture14 File
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  Biostat problems lecture14 File
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  Session Audio/Video Recording (Access restricted to registered students):
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  Required Reading:
  
  See Assignment Files
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  Resources:
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  Assignment: Optional narrative description
- Select activity Common problems HW
  
  Common problems HW File
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  Common problems HW File
- Select activity Homework paper HbA1c disparities
  
  Homework paper HbA1c disparities File
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  Homework paper Uganda ART pregnancy File
Select section Tuesday, April 22, 2014; 12:00 PM - 1:00 PM

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Tuesday, April 22, 2014; 12:00 PM - 1:00 PM
Homework Session

Faculty: John Kornak

Location: China Basin 6702
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  Assignment Answer Key (Access restricted to registered students):
Select section Thursday, April 24, 2014; 10:30 AM - 12:00 PM

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Thursday, April 24, 2014; 10:30 AM - 12:00 PM
Lecture: Common biostatistical problems and survival analysis
Discussion of readings. Competing risks survival analysis

Faculty: John Kornak

Location: China Basin 6702
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  Session Slides:
- Select activity lectureS4
  
  lectureS4 File
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  lectureS4 6slidesPerSheet File
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  lectureS4 File
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  Session Audio/Video Recording (Access restricted to registered students):
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  Resources:
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  2014StudentsToAdvisorsV3final File
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  mros File
Select section Tuesday, April 29, 2014; 10:30 AM - 12:00 PM

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Tuesday, April 29, 2014; 10:30 AM - 12:00 PM
Lecture: Repeated measures data
Introduction to repeated measures data; correlation structures.

Faculty: Chuck McCulloch

Location: China Basin 6702
- Select activity Session Slides:
  
  Session Slides:
- Select activity Repeated measures lecture 1
  
  Repeated measures lecture 1 File
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  Session Audio/Video Recording (Access restricted to registered students):
- Select activity Required Reading: Chapter 7.1-7.4, VGSM
  
  Required Reading:
  
  Chapter 7.1-7.4, VGSM
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  Assignment:
- Select activity Repeated measures hwk
  
  Repeated measures hwk File
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  Repeated measures hwk File
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  hers subset nodm File
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  GAbabies File
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  oai pain File
Select section Thursday, May 1, 2014; 10:30 AM - 12:30 PM

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Thursday, May 1, 2014; 10:30 AM - 12:30 PM
Computer Lab: Repeated measures data

Faculty: Barbara Grimes, Chuck McCulloch

Location: Kornak CB 6702. Grimes CB 6704
- Select activity Assignment:
  
  Assignment:
- Select activity lab 1 repeated measures
  
  lab 1 repeated measures File
- Select activity lab 1 repeated measures
  
  lab 1 repeated measures File
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- Select activity oai
  
  oai File
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  GAbabies File
Select section Tuesday, May 6, 2014; 10:30 AM - 12:00 PM

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Tuesday, May 6, 2014; 10:30 AM - 12:00 PM
Lecture: Repeated measures data
Fixed and random factors; prediction; Stata’s XTMIXED and XTGEE, model checking.

Faculty: Chuck McCulloch

Location: China Basin 6702
- Select activity Session Slides:
  
  Session Slides:
- Select activity Repeated Measures Lecture 2
  
  Repeated Measures Lecture 2 File
- Select activity Session Audio/Video Recording (Access restricted t...
  
  Session Audio/Video Recording (Access restricted to registered students):
- Select activity Required Reading: Chapter 7.4-7.7, VGSM
  
  Required Reading:
  
  Chapter 7.4-7.7, VGSM
Select section Thursday, May 8, 2014; 10:30 AM - 12:30 PM

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Thursday, May 8, 2014; 10:30 AM - 12:30 PM
Computer Lab: Repeated measures data

Faculty: Barbara Grimes, Chuck McCulloch

Location: Kornak CB 6702. Grimes CB 6704
- Select activity Assignment:
  
  Assignment:
- Select activity lab 2 repeated measures
  
  lab 2 repeated measures File
- Select activity lab 2 repeated measures
  
  lab 2 repeated measures File
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- Select activity Datasets:
  
  Datasets:
- Select activity oai thru 18 months
  
  oai thru 18 months File
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  mousewght File
- Select activity fecfat
  
  fecfat File
Select section Tuesday, May 13, 2014; 10:30 AM - 12:00 PM

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Tuesday, May 13, 2014; 10:30 AM - 12:00 PM
Lecture: Repeated measures data
Generalized linear models; non-normal outcomes; robust standard errors; use of nonlinear link functions.

Faculty: Chuck McCulloch

Location: China Basin 6702
- Select activity Session Slides:
  
  Session Slides:
- Select activity Repeated measures lecture 3
  
  Repeated measures lecture 3 File
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  Session Audio/Video Recording (Access restricted to registered students):
Select section Thursday, May 15, 2014; 10:30 AM - 12:30 PM

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Thursday, May 15, 2014; 10:30 AM - 12:30 PM
Computer Lab: Repeated measures data

Faculty: Barbara Grimes, Chuck McCulloch

Location: Kornak CB 6702. Grimes CB 6704
- Select activity Assignment:
  
  Assignment:
- Select activity Repeated measures Lab 3
  
  Repeated measures Lab 3 File
- Select activity Repeated measures lab 3
  
  Repeated measures lab 3 File
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  Assignment Answer Key (Access restricted to registered students):
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  Datasets:
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  backpain File
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  GAbabies File
Select section Tuesday, May 20, 2014; 10:30 AM - 12:00 PM

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Tuesday, May 20, 2014; 10:30 AM - 12:00 PM
Lecture: No Class. Week reserved for finishing mentored data.
Select section Thursday, May 22, 2014; 10:30 AM - 12:30 PM

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Thursday, May 22, 2014; 10:30 AM - 12:30 PM
Computer Lab: No Class. Week reserved for finishing mentored data.
Select section Tuesday, May 27, 2014; 10:00 AM - 1:00 PM

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Tuesday, May 27, 2014; 10:00 AM - 1:00 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: CB 6704, CB 5740, CB 6601
Select section Thursday, May 29, 2014; 10:30 AM - 12:30 PM

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Thursday, May 29, 2014; 10:30 AM - 12:30 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: CB 6704, CB 5740, CB 6601
Select section Tuesday, June 3, 2014; 10:00 AM - 1:00 PM

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Tuesday, June 3, 2014; 10:00 AM - 1:00 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: CB 6704, CB 5740, CB 6601
Select section Thursday, June 5, 2014; 10:30 AM - 12:30 PM

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Thursday, June 5, 2014; 10:30 AM - 12:30 PM
BIOSTATS III Presentations

Faculty: John Kornak, TBA

Location: CB 6704, CB 5740, CB 6601
Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)
Example Date format: Tuesday, July 30, 2013; 1:15 PM - 2:45 PM

<Activity> < optional: insert title>
Lecture narrative description here

Activity options are: Lecture, Small Group Discussion Section, Computer Lab, Journal Club, and Office Hours. Lectures will always have titles but other activities typically won’t. For online activities, add (Times and dates for online sessions may differ)

Faculty: (examples: Mark Pletcher; Mark Pletcher and Jeff Martin)

Location: (e.g., China Basin 6702; or, for small groups: Martin CB 6702, Cheng CB 6601, Jones CB 5740, and Smith CB 5601 )

Sunday	Monday	Tuesday	Wednesday	Thursday	Friday	Saturday
			No events, Wednesday, July 1 No events, Wednesday, July 1	No events, Thursday, July 2 No events, Thursday, July 2	No events, Friday, July 3 No events, Friday, July 3	No events, Saturday, July 4 No events, Saturday, July 4
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No events, Sunday, July 26 No events, Sunday, July 26	No events, Monday, July 27 No events, Monday, July 27	No events, Tuesday, July 28 No events, Tuesday, July 28	No events, Wednesday, July 29 No events, Wednesday, July 29	No events, Thursday, July 30 No events, Thursday, July 30	No events, Friday, July 31 No events, Friday, July 31

July 2026

Section outline

Computer Lab: No Class. Week reserved for finishing mentored data.