Help with Problem set 7 question 8.4c

Help with Problem set 7 question 8.4c

by Teresa Wang -

I'm having trouble with 8.4c:

Let's suppose that this medication only works for true migraines and that everyone in the trial was sufficiently screened that all of them had true migraines.  But out in the "real world" we are considering treating someone with headaches that we think might be migraines, but we are unsure.  If we believe it is worth $500 to prevent one headache day, and if there were no other therapeutic options available, at what probability of migraine would the headache reduction benefit of fremanezumab justify the cost?

If your CBOP is $500 and you want to find the Ptt where the benefit justifies the cost, is it as simple as the BBOP would be $501 (If BBOP > CBOP, treat). So your Ptt is 500/501 = 0.99. That seems a bit high???

I think I'm way off base, any hints for this question?


Re: Help with Problem set 7 question 8.4c

by Vittorio Fasulo -

Hi, are you referring to 8.4d?

 if yes , probably I'm wrong ,but I interpreted that BBOP is 500$ because it said that "If we believe it is worth $500 to prevent one headache day" , and BBOP is Benefit per Bad Outcome Prevented. 

So I used as CBOP  the result of the problem 8.4c.

Let me know what do you think. 




Re: Help with Problem set 7 question 8.4c

by Michael Kohn -

Dear All,

Vittorio is correct.  In 8.4(d), the benefit per headache-day prevented is $500.  This is BBOP.  From 8.3(c), we know the treatment reduces headache days by 1.5 per month at a cost of $600 per month.  From that, you should be able to calculate CBOP, the cost per headache day prevented.

Best,

Michael


Re: Help with Problem set 7 question 8.4c

by Teresa Wang -

Thanks for the help! I understand it now