Thursday, April 28, 2022; 8:30 -10:00 am

Session Slides:

Session Audio/Video Recording (Access restricted to registered students):

Recommended Cochrane Handbook sections:

• Part 2 - Chapter 7: Considering bias and conflicts of interest among the included studies
• Part 2 - Chapter 8: Assessing risk of bias in a randomized trial
• Part 4 - Chapter 25: Assessing risk of bias in a non-randomized study
• Part 2 – Chapter 15: Interpreting results and drawing conclusions (You can skip following sections: 15.4.4, 15.5.3.1 – 15.5.3.5)

Optional Reading:

• Juni et al. Hazards of scoring the quality of clinical trials for meta-analysis. JAMA. 1999;1054-60.
• Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, Baker P, Smith E, Buchbinder R. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012 Sep;65(9):934-9. doi: 10.1016/j.jclinepi.2011.11.014. Epub 2012 Jun 27. PMID: 22742910.
• Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, Carpenter JR, Chan AW, Churchill R, Deeks JJ, Hróbjartsson A, Kirkham J, Jüni P, Loke YK, Pigott TD, Ramsay CR, Regidor D, Rothstein HR, Sandhu L, Santaguida PL, Schünemann HJ, Shea B, Shrier I, Tugwell P, Turner L, Valentine JC, Waddington H, Waters E, Wells GA, Whiting PF, Higgins JP. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016 Oct 12;355:i4919. doi: 10.1136/bmj.i4919. PMID: 27733354; PMCID: PMC5062054.

Additional resources:

• https://www.riskofbias.info/

Assignment #4 (40% of grade): Conduct meta-analysis, generate forest plot (s), and provide brief answers to questions about your analysis outputs.

Due: May 7, 2022

• Download the Assignment 4 Word document for instructions.
• A brief overview of the assignment: Students will receive a small dataset from the instructors. You are responsible to conduct meta-analysis to pool data for those studies, perform sub-group analysis and sensitivity analysis, and answer questions about the outputs of your analyses. Instructions for how to perform meta-analysis and those steps are provided as a part of Module 4 practice (40%). Detailed instructions with be provided. This assignment should not take more than 3-4 hours.