Section outline

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  • Tuesday, January 5, 2016; 1:00 PM - 3:00 PM

    Lecture: Introduction: The Big Picture

    The process of genetic epidemiology; general approaches to assess the genetic basis of disease.

    Faculty:  John Witte

    Location:      Mission Hall 1406

    • Session Slides:

    • Lecture 1 File
    • Lecture 1 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      (Required Reading to be completed before lecture always.)

      Chapter 1 of Genetic Epidemiology: Methods and Applications, by Melissa A. Austin. CABI, 2013. ISBN: 978-1780641812.

      Books may be purchased either through the publisher or a variety of commercial venues (e.g., Amazon.com), where you can also read the beginning of the first chapter.

    • Assignment:

    • Assignment 1 File

    • Final Exam: Optional narrative description

    • Final Project File

  • Tuesday, January 12, 2016; 1:00 PM - 3:00 PM

    Lecture: Population Genetics, Modeling Genetic Inheritance

    Basics of population genetics; aggregation; heritability

    Faculty:  John Witte

    Location:      Mission Hall 1406

    • Session Slides:

    • Lecture 2 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 2

    • Assignment:

    • Assignment 2 File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, January 19, 2016; 1:00 PM - 3:00 PM

    Lecture: Mendel's Laws and Molecular Genetics

    Mendel's laws (segregation, assortment); molecular measures; genotyping; arrays; sequencing

    Faculty:  Joe Wiemels

    Location:      Mission Hall 1406

    • Session Slides:

    • Lecture 3 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 3

    • Assignment:

    • Assignment 3 File
    • MTHFR File
    • MTHFR File
    • MTHFR File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, January 26, 2016; 1:00 PM - 3:00 PM

    Lecture: Family-based Studies

    Linkage analysis, Family-based association studies, TDT, FBAT

    Faculty:  Thomas Hoffmann

    Location:      Mission Hall 1406

    • Session Slides:

    • Lecture4-FamilyBasedStudies File
    • Lecture4-FamilyBasedStudies File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 4

    • Assignment:

    • Assignment 4 File
    • MTHFRcase control File
    • MTHFR case control File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, February 2, 2016; 1:00 PM - 3:00 PM

    Lecture: Genetic Association Studies

    General principles; candidate gene studies

    Faculty:  Thomas Hoffmann

    Location:      Mission Hall 1406

    • Session Slides:

    • Lecture5-Association File
    • Lecture5-Association File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 5

    • Assignment 5 File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, February 9, 2016; 1:00 PM - 3:00 PM

    Lecture: Genome-wide Association Studies (GWAS)

    Agnostic searches across genome for associated SNPs; multiple testing; imputation; consortia.

    Faculty:  Tom Hoffmann

    Location:      Mission Hall 1406

    • Session Slides:

    • Lecture6 GWAS File
    • Lecture6 GWAS File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 6

    • Assignment: Optional narrative description

    • assign6 File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, February 16, 2016; 1:00 PM - 3:00 PM

    Lecture: Admixture Analysis

    Population substructure, admixture mapping.

    Faculty:  Laura Fejerman

    Location:  Mission Hall 1406

    • Session Slides:

    • Lecture 7 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Winkler et al. Admixture mapping comes of age. Ann Rev Genom Human Genet 2010 11:65-89. Read through the "Amixed populations" section.

    • Assignment: Optional narrative description

    • Assignment 7 File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, February 23, 2016; 1:00 PM - 3:00 PM

    Lecture: Gene-Environment Interactions and Epistasis

    Interactions; pharmacogenetics; less common & rare variants; pleiotropy

    Faculty:  John Witte

    Location:  Mission Hall 1406

    • Session Slides:

    • Lecture 8 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 7

    • Resources:

    • assign8 File

    • Assignment

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, March 1, 2016; 1:00 PM - 3:00 PM

    Lecture: Non-mendelian genetics

    Mitochondrial (MT); de novo; parent-of-origin; methylation

    Faculty:  Eric Jorgenson

    Location:  Mission Hall 1406

    • Session Slides:

    • Lecture 9-Non-Mendelian Genetics File
    • Lecture 9-Non-Mendelian Genetics File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 8

    • Final Project File

  • Tuesday, March 8, 2016; 1:00 PM - 3:00 PM

    Lecture: Next Generation Sequencing

    Full genome and exome sequencing studies. Software for genetic analysis.

    Faculty:  Eric Jorgenson

    Location:  Mission Hall 1406

    • Session Slides:

    • Lecture 10-Next Generation Sequencing File
    • Lecture 10-Next Generation Sequencing File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 9

  • Tuesday, March 15, 2016; 1:00 PM - 3:00 PM

    Lecture: Putting it all Together: Incorporating Molecular and Genetic Measures into Your Research

    Final Project Presentations.

    Faculty:  John Witte, Tom Hoffmann

    Location:      Mission Hall 1406

    • Required Reading:

      Austin Chapter 10 & 11