I just want to make sure I am understanding the question right:
You are trying to estimate the likelihood that a
fetus of a first-time mother has Trisomy 21.
How would you expect the LR+ for the mother being over 35 years old to
differ in San Francisco compared with Todd County, SD?
When it states "the LR+" for the mother being over 35 years old - do you mean what is the LR of Trisomy 21 based on the dichotomous <35 vs. >35 age cutoff (i.e. the LR for if a mother is >35) or is this a question of if the child has Trisomy 21, what is the likelihood for the mother being over 35. It's this "for the mother being over 35" part that I am confused about.
Thanks