Article with age as the time dimension: “Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models”
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0422-4
In this article, the authors are interested in identifying why some children are more susceptible to symptomatic (vs asymptomatic) malaria than others. The study sample comprises 2 cohorts of about 1500 children followed over 15 years on a weekly basis in coastal Kenya. In this longitudinal study, the time dimension used is age and children where enrolled at birth and followed for 5 to 15 years. Analytically, the idea was to identify children with excessive number of symptomatic malaria and age-matched (nested case-control) them to children with “average number of symptomatic malaria” but similar exposure (environmental exposure index based on overall transmission intensity). Higher parasite densities and hemoglobin genotype were found as risk factors.
Article with time since study enrollement as the time dimension: “Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study”
https://www.ncbi.nlm.nih.gov/pubmed/21856232
In this study, the authors used longitudinal data collected daily between 2007 and 2010 in a cohort of 405 people from a village in central Senegal resulting in 17858 person-months of follow-up. The research question aimed at assessing the impact of mass distribution to the entire village of long-lasting insecticides treated bed nets (LLIN) in 2008. Time since enrollment in the study was used as the time dimensions but was sub-divided also considering time since treatment and time since 2010 to understand the long term effects of the intervention. The analysis consisted in comparing incidence rates before intervention, after intervention and 2 years after intervention to assess the short-term and long-term effect of LLINs.
Article with time since study enrollement as the time dimension: “Intervals to Plasmodium falciparum recurrence after anti-malarial treatment in pregnancy: a longitudinal prospective cohort”
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-015-0745-9
In this study, the authors were investigating the effect of different malaria treatment combinations on recurrences of malaria episode among pregnant women. In this longitudinal study, a cohort of 700 pregnant women was followed between 1994 and 2009. 481 novel episodes of malaria and 428 recrudescent episodes were observed. Time since first malaria episodes was used as the time dimension. Analytically, the geometric mean number of days to recurrence was compared by treatment groups using log-linear regression.