Hi Rob,
Based on my clinical experiences, Prazosin is highly prescribed and recommended for those suffering from PTSD and recurring nightmares. The article posted for this discussion did highlight the fact that it wasn't effective in treating this condition; however, as you've stated, there exists the need for other populations to be examined as this was a primarily military-dominated research study. You mentioned that sleep is such an integral component pertaining to mood. Addressing this component can alleviate depressive symptoms and perhaps perhaps impact one's mood. At least with the PTSD patients that I see, many of them complain of lack of sleep or lack of quality sleep. This is definitely something to look into.
According to one research article I found, it outlined some of the key aspects pertaining to the results. It revealed that based on the veteran population studied, Prazosin was effective for trauma-related nightmares and sleep disturbances compared to the placebo (Raskind et al., 2003). Additionally, the use of the medication as a cost-effective measure should also be considered compared to expensive alternatives. However, the study did concede to the point that civilian trauma PTSD would need further research.
Raskind, M. A., Peskind, E. R., Kanter, E. D., Petrie, E. C., Radant, A., Thompson, C. E., … McFall, M. M. (2003). Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: A placebo-controlled study. American Journal of Psychiatry, 160(2), 371-373. doi:10.1176/appi.ajp.160.2.371