I am also surprised that prazosin is deemed as ineffective for PTSD nightmares. At my current clinical setting and work place both psychiatrists order prazosin all the time for nightmares.
I would think that if the medication is ineffective as the Raskind et al. (2018) article suggests, then it makes me question why both providers would continuously use prazosin as their drug of choice?
Although, I am not an expert on prazosin, but the frequency that it is prescribed leads me to believe it is efficacious. The patients that I have had a chance to follow up with report that prazosin helped alleviate nightmares and anxiety associated with PTSD.
Another point that I found extremely useful in this discussion was identifying the author’s agenda for writing this article. I never thought about looking up the author of an article and will use this as a tool for future research. This brings to mind the importance of understanding and analyzing literature and doing further research before coming to a conclusion about the topic.
Raskind, M.A., Peskind, E.R., Chow, B., Harris, C., Davis-Karim, A., Holmes, H.A., . . .& Romesser, J.(2018). Trial of prazosin for post-traumatic military veterans. New England Journal of Medicine, 378 960, 507-517.