Section outline

  • LGD: Quantifying the benefits and harms of treatments using RCTS / Alternatives to RCTs
    RCT checklist; importance of baseline incidence; measures of effect size: Relative risk (RR), relative risk reduction (RRR), Odds ratio (OR), Absolute risk reduction (ARR), Number needed to treat (NNT);   "Back of the Envelope Cost Effectiveness Analysis" 

    Faculty:  Thomas Newman

    • Lecture Slides:

    • Newman RCTs lecture 2020-1027 with 2021 Speaker notes File

    • Lecture Audio/Video Recording (Access restricted to registered students):

    • Lecture 7 Part 1, (Introduction and critical appraisal of RCTs; 37:52) 2020-1028 URL
      Not available unless: You belong to Registered students only
    • Lecture 7, Part 2 (Quantifying treatment effects; 42:33) 2020-1028 URL
      Not available unless: You belong to Registered students only

    • Large Group Discussion (Access restricted to registered students):
      Brief formal review of lecture followed by question and answer discussion. Recorded lecture should be viewed prior to this session.

    • Zoom Recording of Large Group Discussion 11/2/2021 Media Resource
      Not available unless: You belong to Registered students only

    • Required Reading: 

      EBD-2: Chapter 8

    • RCT EquationSheet File

      This is an expanded version of Table 8.1 created by Nicole Rodriquez.

    • Optional Reading:

    • LeNoury 2015 BMJ Restoring Study 329 File
      Not available unless: You belong to a group in Registered Students Only
    • Newman 2004 NEJM Antidepressant Perspective File
      Not available unless: You belong to a group in Registered Students Only
    • Stempel 2016 NEJM AUSTRI study Advair v fluticasone alone File
      Not available unless: You belong to a group in Registered Students Only
    • Stolker 2014 Circulation rethinking composite endpoints in clinical trials File
      Not available unless: Your ID number contains 02
    • Ciani 2013 BMJ Surrogate vs patient relevant outcomes File
      Not available unless: Your ID number contains 02
    • Miner 2017 Am J Gastro Pecanatide for chronic constipation File
      Not available unless: Your ID number contains 02

    • Resources:

    • How Do We Know What We Know? Recording of TN lecture on industry-sponsored research and marketing. [52:16] URL

      This recording has some of the same examples as the lecture on Chapter 8; feel free to skip around.

    • Homework Assignment: Problem set #7 (RCTs)

    • Problem Set #7 File

    • Assignment due date:  11/05/2020 at 1:15 pm

    • Problem Set #7 (Upload) Assignment

    • Assignment Answer Key (Access restricted to registered students):

    • Epi 204 PSET7 Answers File