Section outline

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  • Wednesday, August 2, 2017, 9:00 AM - 10:15 AM

    Lecture: The Research Question

    Introduction to the course; components ("anatomy") of a research protocol and "physiology" of research; examples from course faculty research.

    Faculty:  Peter Chin-Hong/Miriam Kuppermann

    Location:      HSW 301 (moves to HSW 302 from Monday, August 7 onwards)

    • Prospectus:

    • Welcome/Assignment 1 File

    • Session Slides:

    • Intro to Epi 150.03 DCR 2017 File
    • Intro and the research question DCR File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only

    • Required Reading:

      DCR-4: Chapter 1: The Anatomy and Physiology of Clinical Research

      DCR-4: Chapter 2: Conceiving the Research Question

    • Errata for DCR-3 as of July 18, 2012 File
    • Errata for DCR-4 as of 2015-0831 File

    • Optional Reading:

    • Newman 2003 Stories Statistics BMJ File
      Not available unless: Your ID number contains 02
    • Newman 2006 NEJM Outcomes of TB 25 or more File
    • Newman 1991 AJDC Direct Bili LEJN-2 File

    • Assignment: Assignment one (due at the start of class)

  • Wednesday, August 2, 2017, 10:15 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Armin Afshar, Beth Cohen, Raymond Hsu, Kristen Kangelaris, Chaz Langelier, Benjamin Lee, Kala Metha, Aoife O’Donovan, Suzanne Sharpton, Shan Ward, Daniel West

    Location:  Afshar Online, Cohen S-174, Hsu S-159, Kangelaris S-172, Langelier U-456, Lee S-178, Metha S-180, O'Donovan CL-213, Sharpton CL-214, Ward S-168, West U-460

    • Assignment:

      Download and review full assignment below. Most important:

        1. Read Chapters 1 & 2 of DCR-4
        2. Choose a research question.
        3. Identify and meet with your mentor
        4. Bring a hard copy of a 1-sentence version of your Research Question and a 1/2 to 3/4 page Significance section to class.
        5. Use a citation management program for the references. Take a class if needed.

    • Assignment Due Date:

      Assignment 1, to be completed before August 2


    • Assignment 1 File

  • Monday, August 7, 2017, 9:00 AM - 10:15 AM

    Lecture: Subjects and variables

    Target and accessibile populations; inclusion and exclusion criteria; balancing feasibility and generalizability; sampling; types of variables and measurements; and maximizing precision and accuracy.

    Faculty:  Beth Cohen
     
    Location:      HSW 302

    • Session Slides:

    • DCR Subjects Measurements 2017 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Subjects and Variables lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 3: Choosing the Study Subjects

      DCR-4 Chapter 4: Planning the Measurements

    • How do we know what we know? This is a 52 minute recorded lecture by Tom Newman URL
      Not available unless: Your ID number contains 02

    • Optional Reading:

  • Monday, August 7, 2017, 10:15 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Armin Afshar, Beth Cohen, Raymond Hsu, Kristen Kangelaris, Chaz Langelier, Benjamin Lee, Kala Metha, Aoife O’Donovan, Suzanne Sharpton, Shan Ward, Daniel West

    Location:  Afashar Online, Cohen S-174, Hsu S-159, Kangelaris S-163, Langelier S-170 (Tues. 8/8), Lee S-178, Metha S-180, O'Donovan CL-213, Sharpton CL-214, Ward S-176, West S-157

    • Assignment:

      Download and review full assignment below. Most important:

        1. Read chapters 3 and 4 of DCR-4.
        2. Compose an outline of your study.
        3. Include a more detailed "Study Subjects" and “Variables” section.
        4. Make an appointment to meet with your mentor.
        5. Watch TN's presentation "How do we know what we know?"

    • Assignment Due Date:  

      Assignment 2 due in small group on Monday, August 7, written due to small group instructor by noon on Tuesday, August 8.

    • Assignment 2 File

  • Wednesday, August 9, 2017; 9:00 AM - 10:15 AM

    Lecture: Study Designs

    Faculty:  Kirsten Bibbins-Domingo

    Location:      HSW 302

    • Session Slides:

    • KBD DCR Lecture Slides 2017 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Study Design Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 7: Designing Cross-Sectional and Cohort Studies

      DCR-4 Chapter 8: Designing Case-Control Studies

    • Optional Reading:

  • Wednesday, August 9, 2017, 10:15 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Armin Afshar, Beth Cohen, Raymond Hsu, Kristen Kangelaris, Chaz Langelier, Benjamin Lee, Kala Metha, Aoife O’Donovan, Suzanne Sharpton, Shan Ward, Daniel West

    Location:  Afashar Online, Cohen S-174, Hsu S-159, Kangelaris S-163, Langelier U-456, Lee S-178, Metha S-180, O'Donovan U-458, Sharpton CL-215, Ward S-176, West S-157

    • Assignment:

              Download and review full assignment below. Most important:

        1. Read Chapters 7 and 8 of DCR-4 (and either 12,13 or 18 depending on your study).
        2. Have a clear, detailed understanding of exactly how at least one predictor and one outcome variable for your study will be (or was) measured
        3. Have experience providing tips to colleagues
        4. Be able to list and explain the advantages and disadvantages of basic observational study designs, including case-control, cross-sectional and cohort studies
        5. Understand simple statistics and the application to each of your studies

    • Assignment Due Date:

      Assignment 3 due in small group on Wednesday, August 9, written due to small group instructor by noon on Thursday, August 10.

    • Assignment 3 File

  • Monday, August 14, 2017; 9:00 AM - 10:15 AM

    Lecture: Causality/Clinical Trials 

    Drawing causal inference; chance, bias, and confounding: pros and cons of observational studies and randomized controlled trials; examples from the diabetes literature

    Faculty:  Deborah Grady
     
    Location:  HSW 302

    • Session Slides:

    • Causal Inference 0617 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Causality Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 9: Enhancing Causal Inference in Observational Studies

      DCR-4 Chapter 10:  Designing a Randomized Blinded Trial

      DCR-4 Chapter 11: Alternative Trial Designs and Implementation Issues

  • Monday, August 14, 2017, 10:15 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Armin Afshar, Beth Cohen, Raymond Hsu, Kristen Kangelaris, Chaz Langelier, Benjamin Lee, Kala Metha, Aoife O’Donovan, Suzanne Sharpton, Shan Ward, Daniel West

    Location:  Afashar Online, Cohen S-174, Hsu S-159, Kangelaris S-163, Langelier U-456, Lee S-178, Metha S-180, O'Donovan U-458, Sharpton CL-214, Ward S-176, West S-157

    • Assignment:

      Download and review full assignment below.  Most important:

      1.     Read chapters 9, 10 and 11

      2.     Be very comfortable with the 1-sentence study plan summary

      3.     Have experience providing tips to colleagues

      4.     Be able to propose a logical (if not feasible) alternative design for your research question

        

    • ASSIGNMENT FOUR 2017.dueWeekThree.081717 File

    • Assignment Due Date:  Assignment 4, Part I, due for discussion in section today.  Due electronically August 17th at Noon to Section Leader

  • Wednesday, August 16, 2017, 9:00 AM - 10:15 AM

    Lecture: Sample Size

    An introduction to the concepts and information needed to estimate sample sizes for various types of studies.  It includes suggestions for making more affordably sized studies

    Faculty: Steve Cummings

    Location:  HSW 302

    • Session Slides:

    • Sample Size for DCR 2017 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Sample Size Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapters 5 and 6

  • Wednesday, August 16, 2017, 10:15 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Armin Afshar, Beth Cohen, Raymond Hsu, Kristen Kangelaris, Chaz Langelier, Benjamin Lee, Kala Metha, Aoife O’Donovan, Suzanne Sharpton, Shan Ward, Daniel West

    Location:  Afashar Online, Cohen S-174, Hsu S-159, Kangelaris S-163, Langelier U-456, Lee S-178, Metha S-180, O'Donovan U-458, Sharpton U-506, Ward S-176, West S-157

    • Assignment:

       Download and review full assignment below. Most important:

        1. Provide a contrasting point of view to the traditional view that studies with <80% power are not worthwhile
        2. Be very comfortable with the 1-sentence study plan summary
        3. Have justified the decisions/assumptions you used to estimate your sample size
        4. Know how to use a sample size calculator and the tables in the book to estimate sample size, given the decisions and assumptions you justified
        5. Be able to propose a logical (if not feasible) alternative design for your research question

    • ASSIGNMENT FOUR 2017.dueWeekThree.081717 File

  • Monday, August 21, 2017, 9:00 AM - 10:15 AM

    Lecture: Introduction to Statistics

    Biostatistic pearls.  How to interpret P values, Standard error versus Standard deviation.  Confidence intervals.  Adjustment in multivariable analyses.
     
    Faculty:  Charles McCulloch
     
    Location:      HSW 302

    • Session Slides:

    • DCR lecture biostat 2017 handouts File
    • DCR lecture biostat 2017 handouts File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Introduction to Statistics Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 5: Underlying Statistical Principles (starting on page 46).

  • Monday, August 21, 2017, 10:15 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Armin Afshar, Beth Cohen, Raymond Hsu, Kristen Kangelaris, Chaz Langelier, Benjamin Lee, Kala Metha, Aoife O’Donovan, Suzanne Sharpton, Shan Ward, Daniel West

    Location:  Afashar Online, Cohen S-174, Hsu S-159, Kangelaris S-163, Langelier U-456, Lee S-178, Metha S-180, O'Donovan U-458, Sharpton U-506, Ward S-176, West S-157

    • Assignment:

              Download and review full assignment below. Most important:

        1. Provide a contrasting point of view to the traditional view that studies with <80% power are not worthwhile
        2. Be very comfortable with the 1-sentence study plan summary
        3. Have justified the decisions/assumptions you used to estimate your sample size
        4. Know how to use a sample size calculator and the tables in the book to estimate sample size, given the decisions and assumptions you justified

  • Wednesday August 23, 2017; 9:00 AM - 10:15 AM

    Lecture: Questionnaires and qualitative methods

    Development of questionnaires; adapting existing instruments or items vs creating new ones; pretesting to identify ambiguities.

    Faculty:  Miriam Kuppermann

    Location:      HSW 302

    • Session Slides:

    • Kuppermann DCR 082217 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
      Not available unless: You belong to a group in Registered Students Only
    • 2016 Questionnaires and Qualitative Methods Lecture URL
      Not available unless: You belong to Afshar's Group

    • Required Reading:

      DCR-4 Chapter 15: Designing Questionnaires and Interviews

      DCR-4 Chapter 16: Data Management

  • Wednesday, August 23, 2017, 10:15 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Armin Afshar, Beth Cohen, Raymond Hsu, Kristen Kangelaris, Chaz Langelier, Benjamin Lee, Kala Metha, Aoife O’Donovan, Suzanne Sharpton, Shan Ward, Daniel West

    Location:  Afashar Online, Cohen TBA, Hsu S-159, Kangelaris S-163, Langelier TBA, Lee S-178, Metha S-180, O'Donovan U-458, Sharpton TBA, Ward S-176, West S-157

  • Monday, August 28, 2017, 10:00 AM - 12:00 PM

    Final Peer Review Sessions

    Faculty: TBA

    Location: TBA