Section outline

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  • Tuesday, July 26, 2016; 9:00 AM - 10:00 AM

    Lecture: Introduction to the Course, Clinical Research, and Research Questions

    Introduction to the course; "Anatomy" and "Physiology" of research; Components of a research protocol, and how measurements in a sample are used to draw inferences about a population

    Faculty:  Mark Pletcher
     
    Location:      MB-Genentech Hall 106, Byers Auditorium

  • Tuesday, July 26, 2016; 10:00 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Hal Barron, Michael Cabana, Glenn Chertow, Amy Gelfand, Rachel Issaka,Tracy Lieu, Megumi Okumura, Linda Park, Joel Simon, Erin Van Blarigan, Ralph Wang, Janet Wojcicki
     
    Location:  Barron MH-2109, Cabana MH-2106, Chertow Online, Gelfand MH-2105, Issaka Online, Lieu MH-1109, Okumura MH-1108, Park MH-2110, Simon MH-1106, Van Blarigan MH-2108, Wang MH-2107, Wojcicki MH-1107

  • Tuesday, August 2, 2016; 9:00 AM - 10:00 AM

    Lecture: Subjects and Variables

    Introduction to the Kaiser Permanente Division of Research; target and accessibile populations; inclusion and exclusion criteria; balancing feasibility and generalizability; sampling; types of variables and measurements; maximizing precision and accuracy; example from Alan's research on atrial fibrillation.

    Faculty:  Tom Newman
     
    Location:      MB-Genentech Hall 106, Byers Auditorium

    • Session Slides:

    • Lecture 2 - Tom Newman - Subjects and Variables File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Assignment 2:

      • Read Chapters 3 and 4 of DCR-4
      • Watch Tom Newman's presentation "How do we know what we know?" (see Materials)
      • Make an appointment to meet with your mentor sometime in the next 2 weeks
      • Write 1-page protocol outline for your study
      • Write <1 page "Study Subjects" section
      • Bring paper copy of writing to Small Group on Tuesday, and turn in revised version by Wednesday at Midnight
      • Do Exercise 3 (Chapter 3) and Exercise 3 (Chapter 4) of DCR-4 (Optional)
    • Assignment 2 Details File
    • Assignment 2 Example File

    • Materials:

    • Tom Newman: How do we know what we know? URL

    • Optional reading from Tom Newman relevant to his Subjects and Variables lecture:

    • Newman 2006 NEJM Outcomes of TB 25 or more File
    • Newman 1991 AJDC Direct Bilirubin Measurements in Jaundiced Term Newborns File
    • Newman 2003 Stories Statistics BMJ File

  • Tuesday, August 2, 2016; 10:00 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Hal Barron, Michael Cabana, Glenn Chertow, Amy Gelfand, Rachel Issaka,Tracy Lieu, Megumi Okumura, Linda Park, Joel Simon, Erin Van Blarigan, Ralph Wang, Janet Wojcicki

    Location:  Barron MH-2109, Cabana MH-2106, Chertow Online, Gelfand MH-2105, Issaka Online, Lieu MH-1109, Okumura MH-1108, Park MH-2110, Simon MH-1106, Van Blarigan MH-2108, Wang MH-2107, Wojcicki MH-1107

  • Tuesday, August 9, 2016; 9:00 AM - 10:00 AM

    Lecture: Sample Size, P-Values and Confidence Intervals

    An introduction to the concepts and information needed to estimate sample sizes for various types of studies. It includes suggestions for making more affordably sized studies.

    Faculty: Mark Pletcher
     
    Location:      MB-Genentech Hall 106, Byers Auditorium

    • Session Slides:

    • Lecture 3 - Mark Pletcher - Sample Size File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Assignment 3:

      • Read Chapters 5 and 6 in DCR-4
      • Read Bacchetti 2010 on Sample Size Reasoning (see Materials)
      • Optional: Read Chapter from Goldman Textbook written by Tom and Chuck (see Materials)
      • Watch Chuck's 2012 Sample Size lecture (See Materials)
      • Write a 1/2-page Sample Size Justification (see Assignment Details)
      • Bring paper copy of writing to Small Group on Tuesday, and turn in revised version by Wednesday at Midnight
    • Assignment 3 Details File
    • Assignment 3 Example File

    • Materials:

    • Bacchetti 2010: Current sample size conventions: Flaws, harms and alternatives File
      Not available unless: Your ID number contains 02
    • Statistical Interpretation of Data (Chapter from Goldman Textbook of Medicine, 24th ed, by Tom and Chuck). Note material in green is included only in the online text, hence it is not what is most important. File
      Not available unless: Your ID number contains 02
    • Sample size calculator (CTSI) URL
    • Sample size calculator (Quesgen) URL
    • Downloadable sample size program URL

  • Tuesday, August 9, 2016; 10:00 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Hal Barron, Michael Cabana, Glenn Chertow, Amy Gelfand, Rachel Issaka,Tracy Lieu, Megumi Okumura, Linda Park, Joel Simon, Erin Van Blarigan, Ralph Wang, Janet Wojcicki  

    Location:  Barron MH-2109, Cabana MH-2106, Chertow Online, Gelfand MH-2105, Issaka Online, Lieu MH-1109, Okumura MH-1108, Park MH-2110, Simon MH-1106, Van Blarigan MH-2108, Wang MH-2107, Wojcicki MH-1107

  • Tuesday, August 16, 2016; 9:00 AM - 10:00 AM

    Lecture: Observational Designs and Studies of Diagnostic Tests

    Faculty:  Warren Browner

    Location:      MB-Genentech Hall 106, Byers Auditorium

    • Session Slides:

    • Lecture 4 - Warren Browner - Observational Studies File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Assignment 4:

      • Read Chapters 7, 8, and either 12, 13 or 18 DCR-4
      • Write a short paragraph for Overview of Study Design (See Assignment Details)
      • Write a ½ - ¾-page Measurements Section (see Assignment Details)
      • Write a 1-page outline for a different study (see Assignment Details)
      • Bring paper copy of writing to Small Group on Tuesday, and turn in revised version by Wednesday at Midnight
      • Optional: Do DCR-4 Exercises 7.2 and 8.2
    • Assignment 4 Details File
    • Assignment 4 Example File

    • Materials:

    • Optional reading from Warren Browner:

    • Optional reading on study design:

    • Optional reading on chart review methods (example of Measurements methods):

    • Gilbert 1996 AnnEmergMed Chart review methods File

    • Optional reading on case-control studies:

    • Vandenbroucke Int J Epidemiol 2012 File
    • Wacholder AJE 1992 File

  • Tuesday, August 16, 2016; 10:00 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Hal Barron, Michael Cabana, Glenn Chertow, Amy Gelfand, Rachel Issaka,Tracy Lieu, Megumi Okumura, Linda Park, Joel Simon, Erin Van Blarigan, Ralph Wang, Janet Wojcicki  

    Location:  Barron MH-2109, Cabana MH-2106, Chertow Online, Gelfand MH-2105, Issaka Online, Lieu MH-1109, Okumura MH-1108, Park MH-2110, Simon MH-1106, Van Blarigan MH-2108, Wang MH-2107, Wojcicki MH-1107

     

  • Tuesday, August 23, 2016; 9:00 AM - 10:00 AM

    Lecture: Questionnaires, Data Collection Forms and Data Management

    Development of paper and online questionnaires and data collection forms. The limitations of spreadsheet programs (e.g. Excel) for database management. Alternative software platforms for data collection and management.

    Faculty:  Michael Kohn
     
    Location:      MB-Genentech Hall 106, Byers Auditorium

    • Session Slides:

    • Lecture 5 - Michael Kohn - Data Collection File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Assignment 5:

      • Read Chapters 12, 13, 15, and 16 of DCR-4
      • Bring 1 page of a data collection form (See Assignment Details)
      • Create a corresponding data dictionary (See Assignment Details)
      • Write ½ - ¾ page data management plan for your study (See Assignment Details)
      • Bring paper copy of writing to Small Group on Tuesday, and turn in revised version by Wednesday at Midnight
      • Optional: Do DCR-4 exercises 12.2 and 12.3 (if you’re doing a diagnostic test study) and Chapter 16 exercises (if you’re not taking Epi 218 on Database Management Systems)
    • Assignment 5 Details File
    • Assignment 5 Example File

    • Materials:

    • HOW TO GET A REDCap ACCOUNT 2015-0824 File

  • Tuesday, August 23, 2016; 10:00 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Hal Barron, Michael Cabana, Glenn Chertow, Amy Gelfand, Rachel Issaka,Tracy Lieu, Megumi Okumura, Linda Park, Joel Simon, Erin Van Blarigan, Ralph Wang, Janet Wojcicki  

    Location:  Barron MH-2109, Cabana MH-2106, Chertow Online, Gelfand MH-2105, Issaka Online, Lieu MH-1109, Okumura MH-1108, Park MH-2110, Simon MH-1106, Van Blarigan MH-2108, Wang MH-2107, Wojcicki MH-1107

  • Tuesday, August 30, 2016; 9:00 AM - 10:00 AM

    Lecture: Causal Inference and Randomized Trials

    Faculty:  Deborah Grady

    Location:      MB-Genentech Hall 106, Byers Auditorium

    • Session Slides:

    • Lecture 6 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Assignment 6:

      • Read Chapters 9, 10, and 11 of DCR-4
      • Write <1 page on enhancing inference in your study (See Assignment Details):
      • Bring paper copy of writing to Small Group on Tuesday, and turn in revised version by Wednesday at Midnight
      • Optional: Do DCR-4 All Exercises in Chapter 9 (if you’re doing an observational study) or Chapters 10 and 11 (if you’re doing a trial)
    • Assignment 6 Details File
    • Assignment 6 Example File

    • Materials:

    • Optional reading, especially for students designing studies of diagnostic tests:

    • Page proofs, Evidence-Based Diagnosis, Chapter 7 File
      Not available unless: Your ID number contains 02
    • Page proofs, Evidence-Based Diagnosis, Chapter 8 File
      Not available unless: Your ID number contains 02

  • Tuesday, August 30, 2016; 10:00 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Hal Barron, Michael Cabana, Glenn Chertow, Amy Gelfand, Rachel Issaka,Tracy Lieu, Megumi Okumura, Linda Park, Joel Simon, Erin Van Blarigan, Ralph Wang, Janet Wojcicki  

    Location:  Barron MH-2109, Cabana MH-2106, Chertow Online, Gelfand MH-2105, Issaka Online, Lieu MH-1109, Okumura MH-1108, Park MH-2110, Simon MH-1106, Van Blarigan MH-2108, Wang MH-2107, Wojcicki MH-1107

  • Tuesday, September 6, 2016; 9:00 AM - 10:00 AM

    Lecture: How to Have an Impactful Research Career

    Tips on how to design a study, implement and disseminate the results to make a difference in people's health

    Faculty:  Steve Cummings
     
    Location:      MB-Genentech Hall 106, Byers Auditorium

    • Session Slides:

    • Lecture 7 - Steve Cummings - Creativity and Innovation File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Assignment 7:

      • Read Chapters 17 and 19 of DCR-4
      • Obtain and read a real grant application from your mentor
      • Assemble a complete draft of your 5-page protocol
      • Bring <1 page pretesting plan (See Assignment Details)
      • Bring <1 page unsettled issue discussion – your choice! (See Assignment Details)
      • Bring paper copy of writing to Small Group on Tuesday.  These assignments do not need to be turned in.
    • Assignment 7 Details File

  • Tuesday, September 6, 2016; 10:00 AM - 12:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Faculty:  Hal Barron, Michael Cabana, Glenn Chertow, Amy Gelfand, Rachel Issaka,Tracy Lieu, Megumi Okumura, Linda Park, Joel Simon, Erin Van Blarigan, Ralph Wang, Janet Wojcicki  

    Location:  Barron MH-2109, Cabana MH-2106, Chertow Online, Gelfand MH-2105, Issaka Online, Lieu MH-1109, Okumura MH-1108, Park MH-2110, Simon MH-1106, Van Blarigan MH-2108, Wang MH-2107, Wojcicki MH-1107

  • Monday, September 12, 2016

    Protocols DUE 5:00 PM