Section outline

  • General

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  • Tuesday, September 13, 2016; 8:45 AM - 10:15 AM

    Lecture: Course Introduction; Study Design
    Distinction between designs where the unit of observation is a group of individuals vs. the individual; ecologic fallacy; types of studies with observations on the individual; cohort study as gold standard of observational designs; concept of study base linking cohort, cross-sectional and case-control designs; and design of observational research to emulate a target randomized trial.

    Faculty:  Jeffrey Martin and Ann Schwartz

    Location:  Mission Hall 1400

    • Prospectus:

    • Course Introduction EPI 203 2016 File
    • Course Introduction video URL

    • Session Slides:

    • Study Design 2016 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch URL
    • .MP4 URL

    • Recommended Reading:

    •  S & N: Ch. 1, p. 3 – 32.
    • Wachholder, S. Selection of controls in case-control studies. Am J Epidemiol 135:1019 – 1028, 1992. Focus on “Study Base Principle” p. 1021 - 1024. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Vandenbroucke JP. Prospective vs retrospective: What's in a name? BMJ 302: 249-250, 1991 File
      Not available unless: Your ID number contains 02
    • Vandenbroucke JP and Pearce N. Case control studies: Basic Concepts. International Journal of Epidemiology 41: 1480-1489, 2012 File
      Not available unless: Your ID number contains 02
    • Hernan MA and Robins JM. Using big data to emulate a randomized trial. American Journal of Epidemiology 183:758-764, 2016 File
      Not available unless: Your ID number contains 02

    • Assignment:  Problem Set 1

    • Problem Set 1 Study Design 2016 File

    • Assignment Due Date:  September 20, 2016 at the beginning of Small Group Section

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, September 20, 2016; 8:45 AM - 10:15 AM

    Lecture: Measures of Disease Occurrence I

    Prevalence vs. incidence; the three elements in measuring disease incidence; the concept of a rate; cumulative incidence vs. person-time incidence; concepts of survival analysis—failure time and censoring; calculating cumulative incidence—Kaplan Meier and life-table methods; and assumptions for valid estimates of cumulative incidence.

    Faculty:  Ann Schwartz

    Location:  Mission Hall 1400

    • Prospectus:

    • Announcements in Preparation for Week 2 File

    • Session Slides:

    • Disease Occurrence I 2016 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    •   S & N: Ch. 2

    • Tapia Granados JA. On the terminology and dimensions of incidence. J Clin Epi 50:891-897, 1997. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Kaplan EL and Meier P. Nonparametric estimation from incomplete observations. J. American Stat. Assoc. 282: 457-481, 1958 File
      Not available unless: Your ID number contains 02
    • Rothman K. Measuring disease occurrence and causal effects. In: Epidemiology: An Introduction. Oxford Press, 2012. pgs:pg 38-56. File
      Not available unless: Your ID number contains 02
    • Rich JT et al. A practical guide to understanding Kaplan-Meier curves. Otolaryngol. Head Neck Surg. 143:331-336, 2010. File
      Not available unless: Your ID number contains 02

    • Assignment:  Problem Set 2

    • Problem Set 2 Disease Occurrence I 2016 [WORD version] File
    • Problem Set 2 Disease Occurrence I 2016 [PDF version] File
    • Epi203survival File
    • Summary of basic Stata survival analysis commands File

    • Assignment Due Date:  September 27, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, September 20, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

     

  • Tuesday, September 27, 2016; 8:45 AM - 10:15 AM

    Lecture: Measures of Disease Occurrence II
    Person-time incidence rates; rate is not a proportion; average vs instantaneous incidence rates; person-time based on individual-level vs group-level data; unit of person-time in denominator does not matter; uses of rates; stratified person-time exposure in cohort studies; relationship between incidence rate and cumulative incidence via the exponential formula; use of rates in view of competing events; and the Aalen-Johansen estimator of cumulative incidence. 

    Faculty:  Ann Schwartz

    Location:  Mission Hall 1400

    • Session Slides:

    • Disease Occurrence II 2016 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    •   S & N: Ch. 2

    • Satagopan et al. A note on competing risks in survival data analysis. Brit J Cancer 91:1229-1235, 2004. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Vandenbroucke JP and Pearce N. Incidence rates in dynamic populations IJE 41: 1472-1479, 2012. File
      Not available unless: Your ID number contains 02
    • Tager, IB. Outcomes in cohort studies. Epidemiol Rev 20:15-28, 1998. File
      Not available unless: Your ID number contains 02
    • Grunkemeier et al. Actual and actuarial probabilities of competing risks: Apples and lemons. Ann Thoracic Surg 83:1586-1592, 2007. File
      Not available unless: Your ID number contains 02
    • Koller et al. Competing risks and the clinical community. Statistics in Medicine 31:1089-1097, 2012. File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 3

    • Problem Set 3 Disease Occurrence II 2016 File
    • bccarecurrence File

    • Assignment Due Date: October 4, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, September 27, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

     

  • Tuesday, September 27, 2016; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

    Journal Club

    Application of concepts learned in the course to date in the critical dissection of an article in the applied literature

    Faculty:  Trisha Hue, Jeff Martin, Megha Mehrotra, Ann Schwartz, Kristen Aiemjoy (Wednesday), Vivian Avelino-Silva, Aggrey Semeere

    Location:  Students will stay in the rooms of their prior small group sections. Avelino-Silva Online-Brazil, Semeere Online-Uganda

    • Required Reading:

    • Ondrusova and Ondrus. Epidemiology and treatment delay in testicular cancer patients: a retrospective study. Int Urol Nephrol 40:143-148, 2008 File
      Not available unless: Your ID number contains 02
    • Journal Club Guide to Reviewing an Article File

    • Optional Reading:

    • Rothman K. Writing for Epidemiology. Epidemiology 9:333-337, 1998. File
      Not available unless: Your ID number contains 02
    • Gopen GD and Swan JA. The science of scientific writing. American Scientist 78:550-558, 1990. File
      Not available unless: Your ID number contains 02
    • Writing a Manuscript Template 2016 05 16 File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, October 4, 2016; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

    Lecture: Measures of Disease Association I

    Measures of association in cross-sectional and cohort studies; 2 x  2 tables; prevalence ratio and prevalence odds ratio; advantages and disadvantages of odds ratios; risk, rate, and hazard ratios; difference vs ratio measures; describing measures of association

    Faculty:  Ann Schwartz

    Location:  Mission Hall 1400

    • Session Slides:

    • Disease Association I 2016 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    •   S & N: Ch. 3, except sections 3.2.2 and 3.4.2 (i.e., skip attributable risk); Appendix A3 (P. 435 - 438)

    • Optional Reading:

    • Cummings P. The relative merits of risk ratios and odds ratios. Arch Pediatr Adolesc Med. 163:438-445, 2009. File
      Not available unless: Your ID number contains 02
    • Holcomb et al. An odd measure of risk: use and misuse of the odds ratio. Obstet Gynecol 98:685-688, 2001. File
      Not available unless: Your ID number contains 02
    • Cummings P. Methods for estimating adjusted risk ratios. The Stata Journal 9:175-196, 2009. File
      Not available unless: Your ID number contains 02
    • Poole C. On the origin of risk relativism. Epidemiology 21:3-9, 2010. File
      Not available unless: Your ID number contains 02
    • Andersen et al. Competing risks in epidemiology. Internation Journal of Epidemiology 41:861-870, 2012. File
      Not available unless: Your ID number contains 02
    • Bland JM and Altman DG. The logrank test. BMJ 328:1073, 2004. File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 4

    • Problem Set 4 Disease Association I 2016 File
    • Schwartz et al. Misunderstandings about the effects of race and sex on physicians' referrals for cardiac catheterization. NEJM 341:279 – 283, 1999. File
      Not available unless: Your ID number contains 02
    • Schulman et al. The effect of race and sex on physician's recommendations for cardiac catheterization. NEJM 340:618 – 626, 1999. File
      Not available unless: Your ID number contains 02

    • Assignment Due Date:  October 11, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, October 4, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

     


     

  • Tuesday, October 11, 2016; 8:45 AM - 10:15 AM

    Lecture: Measures of Disease Association II and Measures of Attribution

    Measures of association in a case-control study; equivalence of odds ratio to other measures of association depending on control sampling: case-cohort, incidence density, or prevalent; measures of attribution: attribution among exposed vs attribution in an overall population.

    Faculty:  Ann Schwartz

    Location:  Mission Hall 1400

    • Session Slides:

    • Disease Association II and Attribution 2016 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    • S & N: Ch. 3, including sections 3.2.2 and 3.4.2; Appendix A4 and A5 (p. 438 - 442)

    • Optional Reading:

    • Greenland S and Robins JM. Conceptual problems in the definition and interpretation of attributable fractions. American Journal of Epidemiology 128:1185-1197, 1988. File
      Not available unless: Your ID number contains 02
    • Rockhill B, Newman B, and Weinberg C. Use and misuse of population attributable fractions. American Journal of Public Health 88:15-19, 1998. File
      Not available unless: Your ID number contains 02
    • Rothman KJ and Greenland S. Causation and causal inference in epidemiology. AJPH 95:5145-5150, 2005. File
      Not available unless: Your ID number contains 02
    • Rothman KJ. Causes. Am J Epi 104:587-592, 1976. File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 5

    • Assignment Due Date:  October 18, 2016

    • Problem Set 5 Disease Association II 2016 File
    • fracturegenotype File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, October 11, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

     


     

  • Tuesday, October 11, 2016; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

    Journal Club

    Application of concepts learned in the course to date in the critical dissection of an article in the applied literature


    Faculty:  Trisha Hue, Jeff Martin, Megha Mehrotra, Ann Schwartz, Kristen Aiemjoy (Wednesday), Vivian Avelino-Silva, Aggrey Semeere

    Location:  Students will stay in the rooms of their prior small group sections. Avelino-Silva Online-Brazil, Semeere Online-Uganda

    • Required Reading:

    • Grosso et al. Oral bisphosphonates and risk of atrial fibrillation and flutter in women: A self-controlled case-series safety analysis. PLoS ONE 4:e4720, 2009. File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, October 18, 2016; 8:45 AM - 10:15 AM

    Lecture: Selection Bias

    Internal vs. external validity; definition and classification of bias; distinguishing bias from random error; spotting and minimizing selection bias in descriptive, cross-sectional, case-control, and longitudinal (e.g., cohorts or trials) studies

    Faculty:  Jeffrey Martin

    Location:  Mission Hall 1400

    • Prospectus:

    • Announcements Week 6 File

    • Session Slides:

    • Selection Bias 2016 Final Post File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    • S & N:  Ch. 4, sections 4.1 - 4.2 (p. 109 - 116) and sections 4.4 - 4.4.2 (p. 133 - 139)

    • Optional Reading:

    • Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 15:615-25, 2004. File
      Not available unless: Your ID number contains 02
    • Robinson et al. Systematic review identifies number of stategies important for retaining study participants. J Clin Epi 60:757-765, 2007. File
      Not available unless: Your ID number contains 02
    • Schwartz S et al. Toward a clarification of the taxonomy of bias in Epidemiology textbooks. Epidemiology 26:216-222, 2015. File
      Not available unless: Your ID number contains 02
    • Cole et al. Illustrating bias due to conditioning on a collider. International Journal of Epidemiology 39:417-420, 2010. File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 6

    • Problem Set 6 Selection Bias 2016 File

    • Assignment Due Date:  October 25, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, October 18, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

     


     

  • Tuesday, October 25 2016; 8:45 AM - 10:15 AM

    Lecture: Understanding Measurement: Aspects of Reproducibility and Validity

    Distinguishing reproducibility from validity; how reproducibility influences validity; methods of characterizing reproducibility of measurements (within-subject standard deviation, intraclass correlation coefficient,  coefficient of variation); methods of assessment of validity in the presence and absence of gold standards

    Faculty:  Jeffrey Martin

    Location:  Mission Hall 1400

    • Session Slides:

    • Measurement Reproducibility Validity 2016 Final Post File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    • S & N: Chapter 8 : Sections 8.1 - 8.2 (p. 313 - 315), sections 8.3.1 - 8.3.3 (p. 318 - 328), and section 8.4.2 (p. 348 - 358)

    • Bland and Altman. Measurement error proportional to the mean. BMJ 313:106, 1996. File
      Not available unless: Your ID number contains 02
    • Bland and Altman. Measurement error and correlation coefficients. BMJ 313:41-42, 1996 File
      Not available unless: Your ID number contains 02
    • Bland and Altman. Measurement error. BMJ 313:744, 1996. File
      Not available unless: Your ID number contains 02
    • Mc Dowell and Newell. Measuring Health: A guide to rating scales and questionnaires. Oxford 29-37, 1996. File
      Not available unless: Your ID number contains 02
    • Bland and Altman. Applying the right statistics: analyses of measurement studies. Ultrasound Obstet Gynecol 22: 85-93, 2003. File
      Not available unless: Your ID number contains 02
    • Bland and Altman. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 307-310, 1986. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Weir, JP. Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. JSCR 19:231-240, 2005. File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 7

    • Problem Set 7 Understanding Measurement 2016 File
    • Tips for MS Excel File

    • Assignment Due Date:  November 1, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, October 25, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

     


     

  • Tuesday, October 25, 2016; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

    Journal Club

    Application of concepts learned in the course to date in the critical dissection of an article in the applied literature


    Faculty:  Trisha Hue, Jeff Martin, Megha Mehrotra, Ann Schwartz, Kristen Aiemjoy (Wednesday), Vivian Avelino-Silva, Aggrey Semeere

    Location:  Students will stay in the rooms of their prior small group sections. Avelino-Silva Online-Brazil, Semeere Online-Uganda

    • Required Reading:

    • Lane et al. Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis and Rheumatism 56:3319–3325, 2007. File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, November 1, 2016; 8:45 AM - 10:15 AM

    Lecture: Measurement Bias
    Differential vs non-differential misclassification; independent vs dependent errors;  influence (magnitude and direction of bias) of differential vs. non-differential and independent vs dependent misclassification of exposure, outcome, and confounding variables

    Faculty:  Jeffrey Martin

    Location:  Mission Hall 1400

    • Session Slides:

    • Measurement Bias 2016 Final Post File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    • S & N:  Ch. 4: sections 4.3-4.3.3 (P. 116-133)

    • Optional Reading:

    • Shahar, E. Causal diagrams for encoding and evaluation of information bias. Journal of Evaluation in Clinical Practice 15: 436-440, 2009. File
      Not available unless: Your ID number contains 02
    • Jurek, AM et al. Proper interpretation of non-differential misclassification effects. J Epid 34:680-687, 2005. File
      Not available unless: Your ID number contains 02
    • Berry et al. Impact of misclassification of in vitro fertilization in studies of folic acid and twinning: modelling using population based Swedish vital records. BMJ 1-3, 2004. File
      Not available unless: Your ID number contains 02
    • Hernan and Cole. Causal diagrams and measurement bias. AJE 170:959-962, 2009. File
      Not available unless: Your ID number contains 02
    • Kristensen P. Bias from nondifferential but dependent misclassification of exposure and outcome. Epidemiology 3:210-215, 1992. File
      Not available unless: Your ID number contains 02
    • Fox M et al. Excel spreadsheet calculator from Chapter 6 of Applying Quantitative Bias Analysis to Epidemiologic Data. Springer 2009. File
      Not available unless: Your ID number contains 02
    • Orsini et al. A tool for sensitivity analysis of epi studies Stata Jrnl 8:29-48, 2008. File
      Not available unless: Your ID number contains 02
    • Lash et al. Good practices for quantitative bias analysis Int J Epidemiology 43:1969-1985, 2014. File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 8

    • Problem Set 8 Measurement Bias 2016 File

    • Assignment Due Date:  November 8, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, November 1, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

  • Tuesday, November 8, 2016; 8:45 AM - 10:15 AM

    Lecture: Confounding and Interaction I: General Principles

    Definition and manifestations of confounding; use of counterfactual model to conceptualize origins of confounding; confounding vs confounders; use of directed acyclic graphs (DAGs) to demonstrate and identify confounding and other bias; nuisance causal pathways; importance of defining the research question and understanding the biological system to prevent confounding

    Faculty:  Jeffrey Martin

    Location:  Mission Hall 1400

    • Session Slides:

    • Confounding I 2016 Final Post File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    •   S & N: Ch. 5

    • Jewell, NP. Causal inference and extraneous factors: confounding and interaction. In Statistics for Epidemiology. Chapman and Hall. p. 93-112, 2003. File
      Not available unless: Your ID number contains 02
    • dagitty.net, an open source browser-based environment for creating, editing, and analyzing directed acyclic graphs. URL
    • DAGitty dot net instructions File
    • Notes on reading for Confounding and Interaction I File

    • Optional Reading:

    • Hernan M. Causal knowledge. AJE 156:176-184, 2002. File
      Not available unless: Your ID number contains 02
    • Cole S, Hernan M. Fallibility in estimating direct effects. IJE 31:163-165, 2002. File
      Not available unless: Your ID number contains 02
    • Greenland Pearl Robins. Causal diagrams for epidemiologic research. Epidemiology 10:37-48,1999. File
      Not available unless: Your ID number contains 02
    • Maldonado G and Greenland S. Estimating causal effects. Int J Epi 31:422-429, 2002. File
      Not available unless: Your ID number contains 02
    • Richiardi L et al. Mediation analysis in epidemiology IJE 42:1511-1519, 2013 File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 9

    • Problem Set 9 Confounding and Interaction I 2016 [WORD version] File
    • Problem Set 9 Confounding and Interaction I 2016 [PDF version] File

    • Assignment Due Date:  November 15, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, November 8, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

  • Tuesday, November 8 2016; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

    Journal Club

    Application of concepts learned in the course to date in the critical dissection of an article in the applied literature


    Faculty:  Trisha Hue, Jeff Martin, Megha Mehrotra, Ann Schwartz, Kristen Aiemjoy (Wednesday), Vivian Avelino-Silva, Aggrey Semeere

    Location:  Students will stay in the rooms of their prior small group sections. Avelino-Silva Online-Brazil, Semeere Online-Uganda

    • Required Reading:

    • Rookus M and van Leeuwen FE. Induced abortion and risk for breast cancer. Reporting (recall) bias in a Dutch case-control stduy. Journal of the National Cancer Institute 88:1759-1764, 1996. File
      Not available unless: Your ID number contains 02

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, November 15, 2016; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

    Lecture: Confounding and Interaction II: Concepts of Interaction

    Strategies to minimize confounding; types of interaction; distinguishing interaction from confounding; assessing for interaction; tests of homogeneity; computer implementation

    Faculty:  Jeffrey Martin

    Location:  Mission Hall 1400

    • Session Slides:

    • Confounding and Interaction II 2016 Final Post File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

    • S & N: Ch. 6 and Ch. 1, section 1.4.5 (p. 33 - 38, section on Matching)

      dagitty.net, an open source browser-based environment for creating, editing, and analyzing directed acyclic graphs

    • Optional Reading:

    • VanderWeele TJ and Robins JM. Four types of effect modification: A classification based on directed acyclic graphs. Epidemiology 18: 561-568, 2007. File
      Not available unless: Your ID number contains 02
    • Knol MJ et al. When one depends on the other: Reporting of interaction. Epidemiology 20:161-166, 2009. File
      Not available unless: Your ID number contains 02
    • Knol MJ and VanderWeele TJ. Recommendations for presenting analyses of effect modification and interaction. International Journal of Epidemiology 41:514-520, 2012. File
      Not available unless: Your ID number contains 02
    • VanderWeele and Knol. Tutorial on interaction. Epidemiol Methods 3:33-72, 2014. File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 10

    • Problem Set 10 Confounding and Interaction II 2016 [WORD version] File
    • Problem Set 10 Confounding and Interaction II 2016 [PDF version] File

    • Assignment Due Date:  November 29, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, November 15, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section

    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

  • Tuesday, November 22, 2016 - No Class

     

  • Tuesday, November 29, 2016; 8:45 AM - 10:15 AM

    Lecture: Confounding and Interaction III: Stratified Analysis

    Concept of weighted averages; use of stratification to form adjusted measures; managing multiple confounding paths; software implementation to detect minimally sufficient set for adjustment; limitations of stratification including time-dependent confounding/mediation

    Faculty:  Jeffrey Martin

    Location:  Mission Hall 1400

    • Session Slides:

    • Confounding and Interaction III 2016 Final Post File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Recommended Reading:

      S & N: Ch. 7: sections 7.1 - 7.2.1 (p. 229 - 234) and sections 7.3.3 - 7.3.4 (p. 242 - 248)

      dagitty.net, an open source browser-based environment for creating, editing, and analyzing directed acyclic graphs

    • Optional Reading:

    • Shrier I and Platt W. Reducing bias through directed acyclic graphs. BMC Medical Research Methodology 8:70, 2008. File
      Not available unless: Your ID number contains 02
    • Suarez D et al. Differences between marginal structural models and conventional models in their exposure effect estimates. Epidemiology 22: 586-588, 2011. File
      Not available unless: Your ID number contains 02
    • Greenland S and Pearce N Statistical Foundations for Model Based Adjustments Ann Rev Pub Health 2015 File
      Not available unless: Your ID number contains 02

    • Assignment: Problem Set 11

    • esophageal cancer File
    • Problem Set 11 Confounding and Interaction III 2016 File

    • Assignment Due Date:  December 6, 2016

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, November 29, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda

  • Tuesday, November 29, 2016; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

    Journal Club

    Application of concepts learned in the course to date in the critical dissection of an article in the applied literature


    Faculty:  Trisha Hue, Jeff Martin, Megha Mehrotra, Ann Schwartz, Kristen Aiemjoy (Wednesday), Vivian Avelino-Silva, Aggrey Semeere

    Location:  Students will stay in the rooms of their prior small group sections. Avelino-Silva Online-Brazil, Semeere Online-Uganda

    • Required Reading:

    • Nitz et al. Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. Journal of Clinical Endocrinology & Metabolism 92:3183–3188, 2007. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Lunnetta KL. Genetic association studies. Circulation 118:96-101, 2008. File
      Not available unless: Your ID number contains 02
    • Holliday EG et al. Advanced topics in prognosis: How to use an article about genetic association. JAMA evidence 21.1-431-456, 2009. File
      Not available unless: Your ID number contains 02
    • Glossary JournalClub Genetic Diabetes File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, December 6, 2016; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

    Journal Club

    Application of concepts learned in the course to date in the critical dissection of an article in the applied literature

    Faculty:  Jeffrey Martin

    Location:  Mission Hall 1400

     

    • Session Slides:

    • MMR and Autism NEJM 2002 2016 Final Post File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

    • Madsen, et al. A population-based study of measles, mumps, and rubella vaccination and autism. NEJM 347-1477-82, 2002 File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Von Elm et al. The strengthening the reporting of observational studies. Lancet 370-1453-1457, 2007 File
      Not available unless: Your ID number contains 02
    • Vandenbroucke et al. Strenthening the reporting of observational. PLoS Medicine 4-e297, 2007 File
      Not available unless: Your ID number contains 02

    • Assignment: Final Exam

    • Yaggi et al. Obstuctive sleep apnea as a risk factor for stroke and death. NEJM 353:2034-41, 2005. File
      Not available unless: Your ID number contains 02
    • brcarctv6 File
    • Epi Methods Final Fall 2016 File

    • Final Exam Due Date: Dec. 13 at 4 pm (California time) for students taking the course in-person in San Francisco.  For students in the online version of the course, the due date is Dec. 14, 9 pm (California time). Please log into the CLE (course syllabus) to upload your exam at the prompt below.  Please upload your exam as a .pdf file such that all your formatting will be preserved, and place your name in the name of the file.  If you encounter difficulties, email Olivia De Leon (olivia@epi.ucsf.edu).

    • Upload EPI 203 Final Exam Here Assignment

  • Tuesday, December 6, 2016; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

    Small Group Discussion Section
    Review of prior lecture and problem set

    Faculty: Stephen Asiimwe, Luis Rodriguez, Michelle Roh, James Salazar, Kristen Aiemjoy, Trisha Hue, Jeff Martin, Megha Mehrotra,  Ann Schwartz, Vivian Avelino-Silva, Aggrey Semeere

    Location:  Asiimwe MH-2105, Rodriguez MH-2106, Roh MH-2107, Salazar MH-2108, Aiemjoy MH-1107 (Wednesday), Avelino-Silva Online-Brazil, Semeere Online-Uganda