Section outline

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    • Effective March 9, 2020:  In deference to the coronavirus outbreak, we will not be holding in-person activities for this course at Mission Hall.  Instead, all activities will be implemented via online mechanisms.  The Course Director will be providing additional information, and the relevant changes will be updated on the respective dates on this CLE page.


      Systematic Reviews

      EPI 214 Spring 2020 (1 unit).
      Course Director: Steve Bent, MD.
      Professor, Department of Medicine
      I. Elaine Allen, PhD
      Course Biostatistical Director

  • Tuesday, April 7, 2020; 1:15 PM - 2:45 PM

    Lecture 1: Designing a Systematic Review
    Indications and overview of the steps of systematic reviews, how to formulate research questions and developing a protocol, Data sources, search strategy and publication bias; inclusion and exclusion criteria, quality assessment, data abstraction forms, selection of studies, homogeneity.

    Faculty: Ashok Krishnaswami 

    • SR Class Mtgs and Assignements 2020 File
    • SR Course Overview Page 2020 File

    • Prospectus:

    • Lecture1.2020 File

    • Session Slides:

    • Final Lecture 1 Systematic Review Epi 214 Krishnaswami April 2020 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Prerecorded Lecture 1 2020 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Required Reading:

    • Bent S, Shojania, K, Saint, S. The use of systematic reviews and meta-analyses in infection control and hospital epidemiology. Am J Infect Control. 2004 June:32(4):246-254. File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Moher D, Liberati A , Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. File
      Not available unless: Your ID number contains 02
    • Cooke A, Smith D, Booth A. Beyond PICO: the SPIDER tool for qualitative evidence synthesis. Qual Health Res. 2012 Oct;22(10):1435-43 File
      Not available unless: Your ID number contains 02
    • Ioannidis J. The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses. The Milbank Quarterly, Vol. 94, No. 3, 2016 (pp. 485-514) File
      Not available unless: Your ID number contains 02
    • Grant MJ and Booth A. A typology of reviews: an analysis of 14 review types and associated methodologies. Health Information and Libraries Journal , 26 , pp.91–108 File
      Not available unless: Your ID number contains 02

    • Assignment: NO HOMEWORK to submit, Required reading as shown in Lecture 1 Prospectus.

       

  • Tuesday, April 14, 2020; 1:15 PM - 2:45 PM

    Lecture 2:

    Part A: 45 min: Developing a Protocol for Systematic Review
    Part B: 45 min: Literature Search

    Faculty: Steve Bent (Part A)/E. Whitaker (Part B)

    • Prospectus:

    • Lecture 2.2020 File

    • Session Slides:

    • EPI 214 2020 Part 2 (Evans Whitaker) File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Prerecorded Lecture 2 Part 1 (Steve Bent) Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Prerecorded Lecture 2 Part 2 (Evans Whitaker) Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Optional Reading:

    • Li T, et al. Innovations in data collection, management, and archiving for systematic reviews. Ann Intern Med. 2015 Feb 17;162(4):287-94. File
      Not available unless: Your ID number contains 02

    • Resources:

    • EPI 214 information. Please read first File
    • EPI214Search2020student File
    • SR search planner 2020 File
    • EPI214 2020 File
    • AfibRateRhythmwithcomments File
      Not available unless: Your ID number contains 02

    • Assignment: Submit a DRAFT Systematic Review Protocol, 1-2 pages as described in Lecture 2 Prospectus.

    • Assignment Due Date:  April 14

  • Tuesday, April 21, 2020; 1:15 PM - 2:45 PM

    Lecture 3: Analytical Methods

    Faculty: Stephen Bent

    • Prospectus:

    • Lecture 3 2020 File

    • Session Slides:

    • Bent Lecture 3 - SR Analytical Methods 4-14-20 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Prerecorded Lecture 3 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Optional Reading:

    • Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomized trials. BMC Medicine. 2010;8:18. File
      Not available unless: Your ID number contains 02
    • Juni et al. Hazards of scoring the quality of clinical trials for meta-analysis. JAMA. 1999;1054-60. File
      Not available unless: Your ID number contains 02

    • Assignment: NO HOMEWORK to submit. Optional reading as shown in Lecture 3 Prospectus.

  • Tuesday, April 28, 2020; 1:15 PM - 2:45 PM

    Lecture 4:  Performing a Meta-analysis

    Faculty:  Steve Bent

    • Prospectus:

    • Lecture 4 2020 File

    • Session Slides:

    • Session Audio/Video Recording (Access restricted to registered students):

    • Prerecorded Lecture 4 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment:  April 28, STATA Problem set due

    • Datasets:

    • hw02-1 File
    • hw02-2 File

  • Tuesday, May 5, 2020; 1:15 PM - 2:45 PM

    Lecture 5: New and Advanced Methods for Pooling Studies

    Faculty: Elaine Allen

    • Prospectus:

    • Lecture 5 2020 File

    • Session Videos

    • Intro and Background File
      Not available unless: You belong to a group in Registered Students Only
    • New Stata Commands File
      Not available unless: You belong to a group in Registered Students Only
    • New Techniques File
      Not available unless: You belong to a group in Registered Students Only
    • Some interesting applications File
      Not available unless: You belong to a group in Registered Students Only
    • Viva La Evidence Video to Sing Along File
      Not available unless: You belong to a group in Registered Students Only
    • Short Quiz with Answers File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

    • Fractures, Osteoporosis Drugs, & Mortality File
      Not available unless: Your ID number contains 02
    • Supplementary Materials File
      Not available unless: Your ID number contains 02

    • Optional Reading:

    • Stata Meta-Analysis Manual (Stata 16) File
      Not available unless: Your ID number contains 02
    • Elia N, et al.. How do authors of systematic reviews deal with research malpractice and misconduct in original studies? A cross-sectional analysis of systematic reviews and survey of their authors. BMJ Open. 2016;e010442. File
      Not available unless: Your ID number contains 02

    • Resources:

    • Streptokinase Data File
    • Chaimani - STATA tutorial File
      Not available unless: Your ID number contains 02

    • Assignment: May 5 homework due: 1-2 page critique of 2 systematic reviews as described in Lecture 5 Prospectus

  • Tuesday, May 12, 2020; 1:15 PM - 2:45 PM

    Lecture 6: Performing a Critique of a Systematic Review: Journal Club 

    Faculty: Steve Bent

    • Prospectus:

    • Lecture 6 2020 File

    • Session Slides:

    • Session Audio/Video Recording (Access restricted to registered students):

    • Prerecorded Lecture 6 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Required Reading:

    • Rowe RH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA. Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature. Ann Em Med. 2000;36:181-190 File
      Not available unless: Your ID number contains 02
    • Alter HJ, Koepsell TD, Hilty WM. Intravenous Magnesium as an Adjuvant in AcuteBronchospasm: A Meta-Analysis. Ann Em Med. 2000;36:191-197. File
      Not available unless: Your ID number contains 02

    • Assignment: Due May 12, 2020 (by e-mail to ucsfsystematicreviews2020@gmail.com)

    • Take Home Final Exam:  to be posted May 5, 2020.

    • SR EXAM 2020 File
      Not available unless: You belong to a group in Registered Students Only

    • Final Exam Due: May 19, 2020 (by e-mail to ucsfsystematicreviews2020@gmail.com)