Section outline

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  • Tuesday, January 7, 2014; 1:00 PM - 3:00 PM

    Lecture: Introduction: The Big Picture

    The process of genetic epidemiology; general approaches to assess the genetic basis of disease.

    Faculty:  Thomas Hoffmann

    Location:      China Basin 6702

    • Prospectus:

    • syllabus File
    • final project File

    • Session Slides:

    • Lecture1-TheBigPicture File
    • Lecture1-TheBigPicture File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      (Required Reading to be completed before lecture always.)

      Chapter 1 of Genetic Epidemiology: Methods and Applications, by Melissa A. Austin. CABI, 2013. ISBN: 978-1780641812.

      Books may be purchased either through the publisher or a variety of commercial venues (e.g., Amazon.com), where you can also read the beginning of the first chapter.

    • Assignment:

    • assign1 File

  • Tuesday, January 14, 2014; 1:00 PM - 3:00 PM

    Lecture: Population Genetics, Modeling Genetic Inheritance

    Basics of population genetics; aggregation; heritability

    Faculty:  Thomas Hoffmann

    Location:      China Basin 6702

    • Session Slides:

    • Lecture2-PopulationGenetics File
    • Lecture2-PopulationGenetics File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 2

    • Assignment:

    • assign2 File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, January 21, 2014; 1:00 PM - 3:00 PM

    Lecture: Mendel's Laws and Molecular Genetics

    Mendel's laws (segregation, assortment); molecular measures; genotyping; arrays; sequencing

    Faculty:  Joe Wiemels

    Location:      China Basin 6702

    • Session Slides:

    • Lecture3-MendelsLawsAndMolecularGenetics File
    • Lecture3-MendelsLawsAndMolecularGenetics File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 3

    • Assignment:

    • assign3 File
    • assign3 File
    • MTHFR File
    • MTHFR File
    • MTHFR File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, January 28, 2014; 1:00 PM - 3:00 PM

    Lecture: Family-based Studies

    Linkage analysis, Family-based association studies, TDT, FBAT

    Faculty:  Thomas Hoffmann

    Location:      China Basin 6702

    • Session Slides:

    • Lecture4-FamilyBasedStudies File
    • Lecture4-FamilyBasedStudies File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 4

    • Assignment:

    • assign4 File
    • MTHFRcase control File
    • MTHFR case control File

    • Assignment Answer Key (Access restricted to registered students):

  • Tuesday, February 4, 2014; 1:00 PM - 3:00 PM

    Lecture: Genetic Association Studies

    General principles; candidate gene studies

    Faculty:  John Witte

    Location:      China Basin 6702

    • Session Slides:

    • Lecture 5 2014 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 5

    • Assignment: Optional narrative description

    • Assignment5 2014 File

    • Assignment Answer Key (Access restricted to registered students):

    • Assignment5 2014 key File

  • Tuesday, February 11, 2014; 1:00 PM - 3:00 PM

    Lecture: Genome-wide Association Studies (GWAS)

    Agnostic searches across genome for associated SNPs; multiple testing; imputation; consortia.

    Faculty:  John Witte

    Location:      China Basin 6702

    • Session Slides:

    • Lecture 6 2014 GWAS File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 6

    • Assignment: Optional narrative description

    • Assignment6 2014 File

  • Tuesday, February 18, 2014; 1:00 PM - 3:00 PM

    Lecture: Gene-Environment Interactions and Epistasis

    Interactions; pharmacogenetics; less common & rare variants

    Faculty:  John Witte

    Location:      China Basin 6702

    • Session Slides:

    • Lecture 7 2014 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 7

    • Assignment: Optional narrative description

    • Assignment7 2014 File

  • Tuesday, February 25, 2014; 1:00 PM - 3:00 PM

    Lecture: Non-mendelian genetics

    Mitochondrial (MT); de novo; parent-of-origin; methylation

    Faculty:  Eric Jorgenson

    Location:      China Basin 6702

    • Session Slides:

    • EPI217-Non-Mendelian-Genetics File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 8

    • Assignment: None this week!

  • Tuesday, March 4, 2014; 1:00 PM - 3:00 PM

    Lecture: Next Generation Sequencing

    Full genome and exome sequencing studies. Software for genetic analysis.

    Faculty:  Eric Jorgenson

    Location:      China Basin 6702

    • Session Slides:

    • Next Generation Sequencing-3-4-14 File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Austin Chapter 9

    • Assignment:

      None this week, project due at the end of next week, 3/14. We will assign you to others to give peer feedback in two groups on the following Tuesday.

  • Tuesday, March 11, 2014; 1:00 PM - 3:00 PM

    Lecture: Admixture Analysis

    Population substructure, admixture mapping.

    Faculty:  Neil Risch

    Location:      China Basin 6702

    • Session Slides:

    • AdmixtureAnalysis File

    • Session Audio/Video Recording (Access restricted to registered students):

    • Required Reading:

      Winkler et al. Admixture mapping comes of age. Ann Rev Genom Human Genet 2010 11:65-89. Read through the "Amixed populations" section.

  • Tuesday, March 18, 2014; 1:00 PM - 3:00 PM

    Lecture: Putting it all Together: Incorporating Molecular and Genetic Measures into Your Research

    Final Project Presentations.

    Faculty:  Thomas Hoffmann, John Witte

    Location:      China Basin 6702

    • Required Reading:

      Austin Chapter 10 & 11