EPI 213: Decision and Cost Effectiveness Analysis in Medicine (Winter 2015)

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    Decision and Cost-Effectiveness Analysis in Medicine EPI 213 Winter 2015 (2 units). Course Director: James G. Kahn, MD, MPH. Professor, Department of Epidemiology & Biostatistics

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• Select section Thursday, January 8, 2015; 1:00 PM – 1:45 PM

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  Thursday, January 8, 2015; 1:00 PM – 1:45 PM

  Course Overview
  

  Goal, organization, student projects, grading, substantive snapshot.

  Faculty:  Jim Kahn
  

  Location:  Mission Hall 1406

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    Assignment Due Date:  (e.g.,  1 pm on April 1 2013” or  “At the beginning of Small Group Section”)

     

• Select section Thursday, January 8, 2015; 1:45 PM – 3:00 PM

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  Thursday, January 8, 2015; 1:45 PM – 3:00 PM

  Core lecture 1: Decision Analysis & steps
  

  Purpose and indications for decision analysis; Steps -- formal question, decision trees, probabilities, outcomes, sensitivity analysis.

  Faculty:  Jim Kahn
  
  Location:  Mission Hall 1406

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  • Select activity DCEA15 - Lecture 1 Decision analysis 8-Jan-2015

    

    DCEA15 - Lecture 1 Decision analysis 8-Jan-2015 File
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    DCEA15 Lecture 1 notes File
  • Select activity Sox HC et al Expected Value Decision Making Ch 6 in Sox HC et al--Medical Decision Making 1988

    

    Sox HC et al Expected Value Decision Making Ch 6 in Sox HC et al--Medical Decision Making 1988 File
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• Select section Thursday, January 15, 2015; 1:00 PM – 2:00 PM

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  Thursday, January 15, 2015; 1:00 PM – 2:00 PM

  Small Group Discussion Section: Software Tutorials

  Faculty:  Jim Kahn/Dhruv Kazi
  Location:  Kahn Excel MH

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• Select section Thursday, January 15, 2015; 2:00 PM – 3:30 PM

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  Thursday, January 15, 2015; 2:00 PM – 3:30 PM

  Small Group Discussion Section 1: Decision analysis (trees)

  Faculty:  Jim Kahn or Dhruv Kazi, Elliot Marseille
  
  Location: Kahn or Kazi MH 2109, Marseille MH 2106

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  • Select activity Detsky Part1 Primer Medical Decision-Making Getting started

    

    Detsky Part1 Primer Medical Decision-Making Getting started File
  • Select activity Detsky Part2 Primer Medical Decision-Making Building a tree

    

    Detsky Part2 Primer Medical Decision-Making Building a tree File
  • Select activity Detsky-Naglie Part3 Primer Medical Decision-Making Est Probs and Utilities

    

    Detsky-Naglie Part3 Primer Medical Decision-Making Est Probs and Utilities File
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  • Select activity DCEA15 decision tree templates v1

    

    DCEA15 decision tree templates v1 File
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    DCEA15 HW1 Assignment File
• Select section Thursday, January 22, 2015; 1:00 PM – 2:15 PM

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  Thursday, January 22, 2015; 1:00 PM – 2:15 PM

  Core Lecture 2: Health Outcomes (QALYs, DALYs)
  Specification, measurement, calculation, and incorporation of health status indicators. Discounting.

  Faculty:  Elliot Marseille
  
  Location:  Mission Hall 1406

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  • Select activity DCEA15 updated Lecture 2 Utility QALYs DALYs Discounting-22-Jan-2015

    

    DCEA15 updated Lecture 2 Utility QALYs DALYs Discounting-22-Jan-2015 File
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  • Select activity Shlipak MG Decision Analysis Ch 2 in Friedland DJ et al--Evidence-Based Medicine 1998

    

    Shlipak MG Decision Analysis Ch 2 in Friedland DJ et al--Evidence-Based Medicine 1998 File
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    Murray Lancet2012 DALYs 219 countries GBD 2010 File
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  • Select activity DCEA15 Lecture 2 The DALYs Show-EAM ver2

    

    DCEA15 Lecture 2 The DALYs Show-EAM ver2 File
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    DALY video URL
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  • Select activity DCEA15 QALYs DALYs discounting

    

    DCEA15 QALYs DALYs discounting File
• Select section Thursday, January 22, 2015; 2:15 PM – 3:00 PM

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  Thursday, January 22, 2015; 2:15 PM – 3:00 PM

  Lecture: Special Topics: Hepatitis C treatment
  CEA of treatment with new targeted antivirals

  Faculty:  Jim Kahn/Elliot Marseille
  
  Location:  Mission Hall 1406

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• Select section Thursday, January 29, 2015; 1:00 PM – 2:00 PM

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  Thursday, January 29, 2015; 1:00 PM – 2:00 PM

  Small Group Discussion Section 2: Health Outcomes (QALYs, DALYs)

  Faculty:  Jim Kahn, Elliot Marseille
  
  Location:  Kahn MH 1406,  Marseille MH 1401

  • Select activity Assignment: Optional narrative description

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  • Select activity DCEA15 HW2 Assignment-2

    

    DCEA15 HW2 Assignment-2 File
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    DCEA15 Mam HW2 File
  • Select activity DCEA15 QALYs DALYs discounting

    

    DCEA15 QALYs DALYs discounting File
• Select section Thursday, January 29, 2015; 2:00 PM – 3:00 PM

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  Thursday, January 29, 2015; 2:00 PM – 3:00 PM

  Core Lecture 3: Cost Effectiveness
  Conceptual approach to CEA. Incorporation of costs into the analysis, calculation of the incremental cost-effectiveness ratio (ICER).

  Faculty:  Jim Kahn
  
  Location:  Mission Hall 1406

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  • Select activity DCEA15 Lecture 3 CEA 29-Jan-2015

    

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    Russell File
• Select section Thursday, February 5, 2015; 1:00 PM – 2:15 PM

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  Thursday, February 5, 2015; 1:00 PM – 2:15 PM

  Small Group Discussion Section 3: Cost-Effectiveness

  Faculty:  Jim Kahn, Elliot Marseille
  
  Location:  Kahn MH 1406,  Marseille MH 1401

  • Select activity Assignment: Optional narrative description

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  • Select activity DCEA15 HW3 Assignment

    

    DCEA15 HW3 Assignment File
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  • Select activity DCEA15 Mammog HW3

    

    DCEA15 Mammog HW3 File
• Select section Thursday, February 5, 2015; 2:15 PM – 3:00 PM

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  Thursday, February 5, 2015; 2:15 PM – 3:00 PM

  Lecture: Special Topic: Cost-Effectiveness & HIV
  Review of findings for HIV prevention and treatment in the global setting.

  Faculty:  Jim Kahn, Elliot Marseille
  
  Location:  Mission Hall 1406

  • Select activity CEA of FC DCEA Feb 5 2015

    

    CEA of FC DCEA Feb 5 2015 File
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• Select section Thursday, February 12, 2015; 1:00 PM – 2:15 PM

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  Thursday, February 12, 2015; 1:00 PM – 2:15 PM

  Core Lecture 4: Markov Disease State Modeling
  Uses and design of portrayal of disease states in decision trees.

  Faculty:  Jim Kahn/Elliot Marseille
  
  Location: Mission Hall 1406

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  • Select activity DCEA14 Lecture-4 Markov-Marseille

    

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  • Select activity Naimark D et al Primer on Medical DA--Part 5--Working with Markov Processes In Med Decis Making Apr-Jun 1997

    

    Naimark D et al Primer on Medical DA--Part 5--Working with Markov Processes In Med Decis Making Apr-Jun 1997 File
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  • Select activity DCEA15 Markov template v23

    

    DCEA15 Markov template v23 File
• Select section Thursday, February 12, 2015; 2:15 PM – 3:00 PM

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  Thursday, February 12, 2015; 2:15 PM – 3:00 PM

  Project Consultations

  Faculty:  TBA
  
  Location:  Mission Hall 1406
• Select section Thursday, February 19, 2015; 1:00 PM – 2:30 PM

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  Thursday, February 19, 2015; 1:00 PM – 2:30 PM

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  Small Group Discussion Section 4: Markov Modeling

  Faculty:  Jim Kahn, Elliot Marseille
  
  Location:  Kahn MH 1406,  Marseille MH 1401

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    DCEA15 Markov template v23 File
• Select section Thursday, February 19, 2015; 2:30 PM – 3:00 PM

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  Thursday, February 19, 2015; 2:30 PM – 3:00 PM

  Core lecture 5 (optional): Data inputs

  General approach (base case, range); Health inputs (health outcomes, population traits, hierarchy of evidence); Cost inputs (direct, time); Presentation.

  Faculty:  Jim Kahn
  
  Location:  Mission Hall 1406

  • Select activity DCEA15 Lecture 5 Data v1

    

    DCEA15 Lecture 5 Data v1 File
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    DCEA15 Lecture 5 Notes v2 File
  • Select activity US Preventive Services Task Force Methodology Ch 2 in USPSTF Guide to Clinical Preventative Services 1996

    

    US Preventive Services Task Force Methodology Ch 2 in USPSTF Guide to Clinical Preventative Services 1996 File
• Select section Thursday, February 26, 2015; 1:00 PM – 1:45 PM

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  Thursday, February 26, 2015; 1:00 PM – 1:45 PM

  Small Group Discussion Section 5: Data Inputs

  Faculty:  Jim Kahn, Elliot Marseille
  
  Location:  Kahn MH 1406,  Marseille MH 1401

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  • Select activity DCEA15 Section 5 HW assignment cost efficacy review

    

    DCEA15 Section 5 HW assignment cost efficacy review File
• Select section Thursday, February 26, 2015; 1:45 PM – 3:00 PM

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  Thursday, February 26, 2015; 1:45 PM – 3:00 PM

  Core Lecture 6: Sensitivity Analysis
  Lecture Description: Types of uncertainty; Deterministic SA (one-way, multi-way, scenario); Probabilistic SA (reasons for, data needs, methods); Uses (planning, checking, thresholds, policy.)

  Faculty:  Elliot Marseille
  
  Location:  Mission Hall 1406

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  • Select activity Krahn MD Primer on Med DA--Part 4--Analyzing the Model Interpreting the Results Med Decis Making Apr-Jun 1997

    

    Krahn MD Primer on Med DA--Part 4--Analyzing the Model Interpreting the Results Med Decis Making Apr-Jun 1997 File
• Select section Thursday, March 5, 2015; 1:00 PM – 2:30 PM

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  Thursday, March 5, 2015; 1:00 PM – 2:30 PM

  Small Group Discussion Section 6:  Sensitivity Analysis

  Faculty:  Jim Kahn, Elliott Marseille
  
  Location:  Kahn MH 1406,  Marseille MH 1401

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  • Select activity DCEA15 Section 6 HW assignment sensitivity analysis v2

    

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    DCEA what-if-analysis data table for sensitivity analysis v2 File
• Select section Thursday, March 5, 2015; 2:30 PM – 3:00 PM

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  Thursday, March 5, 2015; 2:30 PM – 3:00 PM

  Office Hours: Project Consultations
  
  

  Faculty:  Jim Kahn
  
  Location:  Mission Hall 1406
• Select section Thursday, March 12, 2015; 1:00 PM - 2:00 PM

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  Thursday, March 12, 2015; 1:00 PM - 2:00 PM

  Lecture: Special Lecture Cardiovascular CEA
  

  Faculty: Dhruv Kazi

  Location:   Mission Hall 1406

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• Select section Thursday, March 12, 2015; 2:00 PM - 3:00 PM

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  Thursday, March 12, 2015; 2:00 PM - 3:00 PM

  Office Hours: Article review
  
  

  Faculty:  Jim Kahn
  
  Location:  Mission Hall 1406

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    DCEA15 HW Article Review File
  • Select activity Lindfors KK et al CE of Mammo Screening Strategies In JAMA 20Sept1995 ocr

    

    Lindfors KK et al CE of Mammo Screening Strategies In JAMA 20Sept1995 ocr File
• Select section Thursday, March 19, 2015; 1:00 PM – 3:00 PM

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  Thursday, March 19, 2015; 1:00 PM – 3:00 PM

  Lecture:  Iron CEA America

  Fun team competition -- with apologies to Iron Chef America

  Faculty:  Jim Kahn

  Location:  Mission Hall 1406

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  • Select activity DCEA15 Iron CEA America 19-Mar-2015 v1

    

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