EPI 213: Decision and Cost Effectiveness Analysis in Medicine (Winter 2020)

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    		Home Overall Schedule Courses Programs Rosters
    Effective March 9, 2020:  In deference to the coronavirus outbreak, we will not be holding in-person activities for this course at Mission Hall.  Instead, all activities will be implemented via online mechanisms.  The Course Director will be providing additional information, and the relevant changes will be updated on the respective dates on this CLE page. Zoom Link: https://ucsf.zoom.us/j/423247047 or +1 669 900 6833 (Meeting ID: 423 247 047) Decision and Cost-Effectiveness Analysis in Medicine EPI 213 Winter 2020 (2 or 3 units). Course Director: Elliot Marseille, DrPh, MPP

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• Select section Thursday, January 9, 2020; 3:15 PM – 5:00 PM

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  Thursday, January 9, 2020; 3:15 PM – 5:00 PM

  Course Overview
  

  Goal, organization, student projects, grading, substantive snapshot.

  Core Lecture 1: Decision Analysis & steps

  Purpose and indications for decision analysis; Steps -- formal question, decision trees, probabilities, outcomes, sensitivity analysis.

  Faculty:  Elliot Marseille
  

  Location:  Mission Hall 1406

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  • Select activity Sox HC et al Expected Value Decision Making Ch 6 in Sox HC et al--Medical Decision Making 1988

    

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    Assignment Due Date: Thursday, January 16 at 3:15 PM

• Select section Thursday, January 16, 2020; 3:15 PM – 5:00 PM

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  Thursday, January 16, 2020; 3:15 PM – 5:00 PM

  Lecture: Software Tutorials

  Group Discussion: Decision analysis (trees)

  Faculty:  Elliot Marseille/Sri Lekha Tummalapalli

  Location:  Mission Hall 1406

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  • Select activity CEA approaches and ICERs

    

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  • Select activity Detsky Part1 Primer Medical Decision-Making Getting started

    

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  • Select activity Detsky Part2 Primer Medical Decision-Making Building a tree

    

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  • Select activity Detsky-Naglie Part3 Primer Medical Decision-Making Est Probs and Utilities

    

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• Select section Thursday, January 23, 2020; 3:15 PM – 5:00 PM

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  Thursday, January 23, 2020; 3:15 PM – 5:00 PM

  Core Lecture 2: Health Outcomes (QALYs, DALYs)
  Specification, measurement, calculation, and incorporation of health status indicators. Discounting.

  Lecture: Special Topic: HIV prevention cost-effectiveness

  CEA of two interventions in global health context - female condom and pMTCT
  

  Faculty:  Elliot Marseille
  
  Location:  Mission Hall 1406

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  • Select activity DCEA19 Lecture 2 Utility QALYs DALYs Discounting-23-Jan-2020

    

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  • Select activity DALYs and QALYs

    

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  • Select activity Shlipak MG Decision Analysis Ch 2 in Friedland DJ et al--Evidence-Based Medicine 1998

    

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  • Select activity Murray Lancet2012 DALYs 219 countries GBD 2010

    

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    Assignment Due Date:  Thursday, January 30 at 3:15 PM

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  Thursday, January 30, 2020; 3:15 PM – 5:00 PM

  Core Lecture 3: Cost-Effectiveness
  Conceptual approach to CEA. Incorporation of costs into the analysis, calculation of the incremental cost-effectiveness ratio (ICER).

  Faculty:  Elliot Marseile
  
  Location:  Mission Hall 1406

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    Assignment Due Date:  Thursday, February 6 at 3:15 PM

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  Thursday, February 6, 2020; 3:15 PM – 5:00 PM

  Lecture: Special Topic: Cost-Effectiveness Thresholds
  Critique of WHO thresholds and the way forward

  Faculty:  Elliot Marseille
  
  Location:  Mission Hall 1406

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• Select section Thursday, February 13, 2020; 3:15 PM – 5:00 PM

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  Thursday, February 13, 2020; 3:15 PM – 5:00 PM

  Obtaining Inputs Data and In-Class Journal Club 

  Core Lecture 4: Data inputs PPT Posted to CLE (Faculty: Jim Kahn)
  

  General approach (base case, range); Health inputs (health outcomes, population traits, hierarchy of evidence); Cost inputs (direct, time); Presentation.

  Location:  Mission Hall 1406

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  • Select activity US Preventive Services Task Force Methodology Ch 2 in USPSTF Guide to Clinical Preventative Services 1996

    

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  • Select activity Kazi PCSK9 Familial Hypercholesterolemia JAMA 2016

    

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  • Select activity Qualitative review of cost studies

    

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    Example of a systematic qualitative assessment of disparate medical care cost studies - from E. Marseille's CEA of MDMA for PTSD.

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• Select section Thursday, February 20, 2020; 3:15 PM – 5:00 PM

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  Thursday, February 20, 2020; 3:15 PM – 5:00 PM

  Core Lecture 5: Sensitivity Analysis
  Lecture Description: Types of uncertainty; Deterministic SA (one-way, multi-way, scenario); Probabilistic SA (reasons for, data needs, methods); Uses (planning, checking, thresholds, policy.)

  Faculty:  Elliot Marseille
  
  Location:  Mission Hall 1406

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  • Select activity Krahn MD Primer on Med DA--Part 4--Analyzing the Model Interpreting the Results Med Decis Making Apr-Jun 1997

    

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• Select section Thursday, February 27, 2020; 3:15 PM – 5:00 PM

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  Thursday, February 27, 2020; 3:15 PM – 5:00 PM

  Lecture: Special Topic: Ethics of Cost-Effectiveness

  Utilitarian and competing ethical principles.
  

  Faculty: Elliot Marseille

  Location:  Mission Hall 1406

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• Select section Thursday, March 5, 2020; 3:15 PM – 5:00 PM

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  Thursday, March 5, 2020; 3:15 PM – 5:00 PM

  Core Lecture 6: Markov Disease State Modeling
  Uses and design of portrayal of disease states in decision trees.

  Faculty:  Elliot Marseille
  
  Location: Mission Hall 1406

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  • Select activity Naimark D et al Primer on Medical DA--Part 5--Working with Markov Processes In Med Decis Making Apr-Jun 1997

    

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• Select section Thursday, March 12, 2020; 3:15 PM – 5:00 PM

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  Thursday, March 12, 2020; 3:15 PM – 5:00 PM

  Article Review

  Location:  Zoom only

  Zoom Link: https://ucsf.zoom.us/j/423247047 or +1 669 900 6833 (Meeting ID: 423 247 047)

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    Assignment: HW7

    NOTE: Assignment deadline has been extended to March 26, 2020.

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    Assignment Due Date:  Final project writeup for "own" projects due Thursday, March 26, 2020 at 3:15 PM.

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• Select section Thursday, March 19, 2020; 3:15 PM - 5:00 PM

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  Thursday, March 19, 2020; 3:15 PM - 5:00 PM

  Iron CEA America

  Fun team competition -- with apologies to Iron Chef America

  Faculty:  Elliot Marseille / Jim Kahn
  

  Location:  Zoom only

  
  

  Zoom Link: https://zoom.us/j/262358867

   Meeting ID: 262 358 867

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