BIOSTAT 226: Statistical Issues in Design, Monitoring, and Analysis of Randomized Controlled Trials (Winter 2020)

Section outline

• Select section

  Collapse Expand

  Collapse all Expand all

  • Select activity Home Overall Schedule Cour...

    		Home Overall Schedule Courses Programs Rosters
    Effective March 9, 2020:  In deference to the coronavirus outbreak, we will not be holding in-person activities for this course at Mission Hall.  Instead, all activities will be implemented via online mechanisms.  The Course Director will be providing additional information, and the relevant changes will be updated on the respective dates on this CLE page. Statistical Issues in Design, Monitoring, and Analysis of Randomized Controlled Trials BIOSTAT 226 Winter 2020 (1 units). Course Director: Joan Hilton, ScD, MPH. Professor, Department of Epidemiology and Biostatistics

  • Select activity News forum

    

    News forum
• Select section Tuesday, January 7, 2020; 10:30 AM – 12:00 PM

  Collapse Expand

  Tuesday, January 7, 2020; 10:30 AM – 12:00 PM

  Lecture:  Design of RCTs:  How to avoid bias and achieve valid results

  
  

  Faculty:  Joan F. Hilton
  
  Location:  Mission Hall 1407

  • Select activity Session Slides:

    Session Slides:

  • Select activity Biostat 226 2020 Lect1 2

    

    Biostat 226 2020 Lect1 2 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity Wittes 2009 MissingOutcomes

    

    Wittes 2009 MissingOutcomes File
  • Select activity Vickers Altman 2013 Missing

    

    Vickers Altman 2013 Missing File
  • Select activity White Horton 2011 MissingOutcomes

    

    White Horton 2011 MissingOutcomes File
  • Select activity Biostat 226 2020 HW1

    

    Biostat 226 2020 HW1 File
  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, January 14, 2020; 10:30 AM – 12:00 PM

  Collapse Expand

  Tuesday, January 14, 2020; 10:30 AM – 12:00 PM

  Lecture: Analysis issues:  Baseline covariates; Efficacy and Safety Outcomes
  

  Faculty:  Joan F. Hilton
  
  Location:  Mission Hall 1407

  • Select activity Session Slides:

    Session Slides:
    

  • Select activity Biostat 226 2020 Lect2 15Jan20

    

    Biostat 226 2020 Lect2 15Jan20 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity Kahan 2014 CovAdj

    

    Kahan 2014 CovAdj File
  • Select activity Austin 2010 Baseline

    

    Austin 2010 Baseline File
  • Select activity Vickers Altman 2013 ChangeScores

    

    Vickers Altman 2013 ChangeScores File
  • Select activity Cole Altman 2017 Transf

    

    Cole Altman 2017 Transf File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Lineberry Berlin 2016 Safety

    

    Lineberry Berlin 2016 Safety File
  • Select activity Assignment: Optional narrative description

    Assignment: Optional narrative description

  • Select activity Assignment:

    Assignment:

  • Select activity Biostat 226 2020 HW2

    

    Biostat 226 2020 HW2 File
• Select section Tuesday, January 21, 2020; 10:30 AM – 12:00 PM

  Collapse Expand

  Tuesday, January 21, 2020; 10:30 AM – 12:00 PM

  Lecture: Monitoring trials for efficacy, futility, and patient safety

  Faculty:  Joan F. Hilton
  
  Location:  Mission Hall 1407

  • Select activity Session Slides:

    Session Slides:
    

  • Select activity Biostat 226 2020 Lect3 21Jan20

    

    Biostat 226 2020 Lect3 21Jan20 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Watch 2018 Lecture

    

    Watch 2018 Lecture URL

    Not available unless: You belong to a group in Registered Students Only
  • Select activity Required Reading:

    Required Reading:

  • Select activity WHI Monitoring

    

    WHI Monitoring File

    Not available unless: Your ID number starts with 02
  • Select activity Demets 2006 futility

    

    Demets 2006 futility File

    Not available unless: Your ID number starts with 02
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Suissa 2012 HRT

    

    Suissa 2012 HRT File

    Not available unless: Your ID number starts with 02
  • Select activity DFF Ch2 Summ LessonsLearned

    

    DFF Ch2 Summ LessonsLearned File

    Not available unless: Your ID number starts with 02
  • Select activity RCTs stopped early

    

    RCTs stopped early File

    Not available unless: Your ID number starts with 02
  • Select activity Assignment: Optional narrative description

    Assignment: Optional narrative description

  • Select activity Biostat 226 2020 HW3

    

    Biostat 226 2020 HW3 File
• Select section Tuesday, January 28, 2020; 10:30 AM – 12:00 PM

  Collapse Expand

  Tuesday, January 28, 2020; 10:30 AM – 12:00 PM

  Lecture: Cluster randomized design
  

  Faculty:  Joan F. Hilton
  
  Location:  Mission Hall 1407

  • Select activity Session Slides:

    Session Slides:
    

  • Select activity Biostat 226 2020 Lect4

    

    Biostat 226 2020 Lect4 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity CRD - BestPractices

    

    CRD - BestPractices File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Wright 2015 CRD

    

    Wright 2015 CRD File
  • Select activity Gao 2015 CRD

    

    Gao 2015 CRD File
  • Select activity Walters 2001 CRT

    

    Walters 2001 CRT File
  • Select activity Minian 2018

    

    Minian 2018 File
  • Select activity Bacchetti 2011 Ncalc

    

    Bacchetti 2011 Ncalc File
  • Select activity Assignment: Optional narrative description

    Assignment: Optional narrative description

  • Select activity Biostat 226 2020 HW4

    

    Biostat 226 2020 HW4 File
• Select section Tuesday, February 4, 2020; 10:30 AM – 12:00 PM

  Collapse Expand

  Tuesday, February 4, 2020; 10:30 AM – 12:00 PM

  Lecture:  Precision Medicine I:  SMART (Adaptive) Trials
  

  
  

  Faculty:  Joan F. Hilton
  
  Location:  Mission Hall 1407

  • Select activity Session Slides:

    Session Slides:
    

  • Select activity Biostat 226 2020 Lect5 03Feb20

    

    Biostat 226 2020 Lect5 03Feb20 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity Murphy 2012

    

    Murphy 2012 File
  • Select activity Optional Reading: (copy)

    Optional Reading:

  • Select activity Murphy 2014 SMART

    

    Murphy 2014 SMART File
  • Select activity ADHD NahumShani 2012

    

    ADHD NahumShani 2012 File
  • Select activity Extend NahumShani 2017

    

    Extend NahumShani 2017 File
  • Select activity Assignment: Optional narrative description

    Assignment: Optional narrative description

  • Select activity Biostat 226 2020 HW5 07Feb20

    

    Biostat 226 2020 HW5 07Feb20 File
  • Select activity Biostat 226 2020 HW5 KEY

    

    Biostat 226 2020 HW5 KEY File
• Select section Tuesday, February 11, 2020; 10:30 AM – 12:00 PM

  Collapse Expand

  Tuesday, February 11, 2020; 10:30 AM – 12:00 PM

  Lecture: Precision Medicine II:  N-of-1 Trials
  

  Faculty:  Joan Hilton
  
  Location:  Mission Hall 1407

  • Select activity Session Slides:

    Session Slides:

  • Select activity Biostat 226 2018 Lect6

    

    Biostat 226 2018 Lect6 File
  • Select activity Required Reading:

    Required Reading:

  • Select activity Schork 2013

    

    Schork 2013 File
  • Select activity Senn 2018 Nature

    

    Senn 2018 Nature File
  • Select activity Carriere 2015 Ch6 MethodologicalConsiderations

    

    Carriere 2015 Ch6 MethodologicalConsiderations File
  • Select activity Assignment Due Date:  Homework 6 is also a ta...

    Assignment Due Date:  Homework 6 is also a take-home final exam. Thus it includes questions from all 6 lectures, is longer than average, and will count for 25% of your grade.  It is due Wednesday February 19. 

  • Select activity Bio226 2020 HW6

    

    Bio226 2020 HW6 File
  • Select activity Bio226 2020 HW6 supplement

    

    Bio226 2020 HW6 supplement File
  • Select activity Olgin 2018 RCT

    

    Olgin 2018 RCT File