EPI 203: Epidemiologic Methods (Fall 2013)

Section outline

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  General

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    Epidemiologic Methods EPI 203 Fall 2013 (4 units) . Course Director: Jeffrey N. Martin, MD, MPH . Professor, Department of Epidemiology and Biostatistics

• Select section Tuesday, September 17, 2013; 8:45 AM - 10:15 AM

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  Tuesday, September 17, 2013; 8:45 AM - 10:15 AM

  Lecture: Course Introduction; Study Design
  Distinction between designs where the unit of observation is a group of individuals vs. the individual; ecological fallacy; types of studies with observations on the individual; cohort study as gold standard of observational designs; concept of study base linking cohort and case-control designs.

  Faculty:  Jeffrey Martin and Ann Schwartz
  
  Location:  China Basin 6702

  • Select activity Prospectus:

    Prospectus:

  • Select activity Course Introduction

    

    Course Introduction URL
  • Select activity Course Introduction

    

    Course Introduction File
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    Session Slides:

  • Select activity Study Design 2013

    

    Study Design 2013 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):
    

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Ch. 1, p. 3 – 32.

    S & N: Ch. 1, p. 3 – 32.

  • Select activity Optional Reading: Vandenbroucke BMJ Prospective v...

    Optional Reading:

    Vandenbroucke BMJ Prospective vs retrospective: Whats in a name. BMJ 32: 249-250, 1991

    Vandenbroucke JP and Pearce N. Case control studies: Basic Concepts. International Journal of Epidemiology 41: 1480-1489, 2012

  • Select activity Assignment:  Problem Set 1 (to be distributed on S...

    Assignment:  Problem Set 1 (to be distributed on September 17)

  • Select activity Problem Set 1 Study Design 2013

    

    Problem Set 1 Study Design 2013 File
  • Select activity Assignment Due Date:  September 24, 2013 at the be...

    Assignment Due Date:  September 24, 2013 at the beginning of Small Group Section

• Select section Tuesday, September 24, 2013; 8:45 AM - 10:15 AM

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  Tuesday, September 24, 2013; 8:45 AM - 10:15 AM

  Lecture: Measures of Disease Occurrence I
  

  Prevalence vs. incidence; the three elements in measuring disease incidence; the concept of a rate; cumulative incidence vs. person-time incidence; concepts of survival analysis—failure time and censoring; calculating cumulative incidence—Kaplan Meier and life table methods.
  

  Faculty:  Ann Schwartz
  
  Location:  China Basin 6702

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    Prospectus:

  • Select activity Announcements Week 2

    

    Announcements Week 2 URL
  • Select activity Announcements Week 2

    

    Announcements Week 2 File
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    Session Slides:

  • Select activity Disease Occurrence I 2013

    

    Disease Occurrence I 2013 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Ch. 2

    S & N: Ch. 2

  • Select activity Tapia Granados, JA. On the terminology and dimensions of incidence. J Clin Epidemiol 50:891 – 897, 1997.

    

    Tapia Granados, JA. On the terminology and dimensions of incidence. J Clin Epidemiol 50:891 – 897, 1997. File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Kaplan EL and Meier P. Nonparametric estimation from incomplete observations. J. American Stat. Assoc. 282: 457-481, 1958

    

    Kaplan EL and Meier P. Nonparametric estimation from incomplete observations. J. American Stat. Assoc. 282: 457-481, 1958 File
  • Select activity Measuring Disease Occurrence and Causal Effects in Epidemiology. In Epidemiology: An Introduction. Kenneth Rothman. Oxford University Press. 2012: p. 38 to 56.

    

    Measuring Disease Occurrence and Causal Effects in Epidemiology. In Epidemiology: An Introduction. Kenneth Rothman. Oxford University Press. 2012: p. 38 to 56. File
  • Select activity Rich JT et al. A practical guide to understanding Kaplan-Meier curves. Otolaryngol. Head Neck Surg. 143:331-336, 2010.

    

    Rich JT et al. A practical guide to understanding Kaplan-Meier curves. Otolaryngol. Head Neck Surg. 143:331-336, 2010. File
  • Select activity Assignment:  Problem Set 2

    Assignment:  Problem Set 2

  • Select activity [WORD VERSION] Problem Set 2 Disease Occurrence I 2013

    

    [WORD VERSION] Problem Set 2 Disease Occurrence I 2013 File
  • Select activity [PDF VERSION] Problem Set 2 Disease Occurrence I 2013

    

    [PDF VERSION] Problem Set 2 Disease Occurrence I 2013 File
  • Select activity Epi203survival

    

    Epi203survival File
  • Select activity Summary of basic Stata survival analysis commands

    

    Summary of basic Stata survival analysis commands File
  • Select activity Assignment Due Date:  October 1, 2013

    Assignment Due Date:  October 1, 2013

• Select section Tuesday, September 24, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, September 24, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set
  

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Aggrey Semeere, Trisha Hue, Jeff Martin, Ann Schwartz

  Location: Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online

   
  
• Select section Tuesday, October 1, 2013; 8:45 AM - 10:15 AM

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  Tuesday, October 1, 2013; 8:45 AM - 10:15 AM

  Lecture: Measures of Disease Occurrence II
  Person-time incidence rates; rate is not a proportion; instantaneous rate; person-time based on grouped data vs. individual data; assumption that ratio of time to number in denominator does not matter; stratified person-time exposure in cohort studies; relationship of prevalence to incidence; competing risks.
  
  Faculty:  Ann Schwartz
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:
    

  • Select activity Disease Occurrence II 2013

    

    Disease Occurrence II 2013 File
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    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Ch. 2

    S & N: Ch. 2

  • Select activity Satagopan et al. A note on competing risks in survival data analysis. Brit J Cancer 91:1229-1235, 2004.

    

    Satagopan et al. A note on competing risks in survival data analysis. Brit J Cancer 91:1229-1235, 2004. File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Vandenbroucke JP and Pearce N. Incidence rates in dynamic populations IJE 41: 1472-1479, 2012.

    

    Vandenbroucke JP and Pearce N. Incidence rates in dynamic populations IJE 41: 1472-1479, 2012. File
  • Select activity Tager, IB. Outcomes in cohort studies. Epidemiol Rev 20:15-28, 1998.

    

    Tager, IB. Outcomes in cohort studies. Epidemiol Rev 20:15-28, 1998. File
  • Select activity Grunkemeier et al. Actual and actuarial probabilities of competing risks: Apples and lemons. Ann Thoracic Surg 83:1586-1592, 2007.

    

    Grunkemeier et al. Actual and actuarial probabilities of competing risks: Apples and lemons. Ann Thoracic Surg 83:1586-1592, 2007. File
  • Select activity Assignment: Problem Set 3

    Assignment: Problem Set 3

  • Select activity Problem Set 3 Disease Occurrence II 2013

    

    Problem Set 3 Disease Occurrence II 2013 File
  • Select activity bccarecurrence

    

    bccarecurrence File
  • Select activity Assignment Due Date: October 8, 2013

    Assignment Due Date: October 8, 2013

• Select section Tuesday, October 1, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, October 1, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, October 1, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

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  Tuesday, October 1, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

  Journal Club
  

  Application of concepts learned in the course to date in the critical dissection of an article in the applied literature
  
  Faculty:  Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere
  
  Location:  Students will stay in the rooms of their prior small group sections. Semeere online.
  

  • Select activity Required Reading:

    Required Reading:

  • Select activity Ondrusova and Ondrus. Epidemiology and treatment delay in testicular cancer patients: a retrospective study. Int Urol Nephrol 40:143-148, 2008

    

    Ondrusova and Ondrus. Epidemiology and treatment delay in testicular cancer patients: a retrospective study. Int Urol Nephrol 40:143-148, 2008 File
  • Select activity Journal Club Guide to Reviewing an Article

    

    Journal Club Guide to Reviewing an Article File
• Select section Tuesday, October 8, 2013; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

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  Tuesday, October 8, 2013; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

  Lecture: Measures of Disease Association I
  

  Measures of association of disease incidence in a cohort; incidence difference versus incidence ratio; risk ratio vs. rate ratio; 2x2 table for exposure and disease measures of association; odds ratio for disease equals odds ratio for exposure; relative risk vs. odds ratio; prevalence ratio.

  Faculty:  Ann Schwartz
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Disease Association I 2013

    

    Disease Association I 2013 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Ch. 3, except sections 3.2.2 and 3.4.2 ...

    S & N: Ch. 3, except sections 3.2.2 and 3.4.2 (i.e., skip attributable risk); Appendix A3 (P. 435 - 438)

  • Select activity Schulman et al. The effect of race and sex on physician's recommendations for cardiac catheterization. NEJM 340:618 – 626, 1999.

    

    Schulman et al. The effect of race and sex on physician's recommendations for cardiac catheterization. NEJM 340:618 – 626, 1999. File
  • Select activity Schwartz et al. Misunderstandings about the effects of race and sex on physicians' referrals for cardiac catheterization. NEJM 341:279 – 283, 1999.

    

    Schwartz et al. Misunderstandings about the effects of race and sex on physicians' referrals for cardiac catheterization. NEJM 341:279 – 283, 1999. File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Cummings P. The relative merits of risk ratios and odds ratios. Arch Pediatr Adolesc Med. 163:438-445, 2009.

    

    Cummings P. The relative merits of risk ratios and odds ratios. Arch Pediatr Adolesc Med. 163:438-445, 2009. File
  • Select activity Holcomb et al. An odd measure of risk: use and misuse of the odds ratio. Obstet Gynecol 98:685-688, 2001.

    

    Holcomb et al. An odd measure of risk: use and misuse of the odds ratio. Obstet Gynecol 98:685-688, 2001. File
  • Select activity Cummings P. Methods for estimating adjusted risk ratios. The Stata Journal 9:175-196, 2009.

    

    Cummings P. Methods for estimating adjusted risk ratios. The Stata Journal 9:175-196, 2009. File
  • Select activity Poole C. On the origin of risk relativism. Epidemiology 21:3-9, 2010.

    

    Poole C. On the origin of risk relativism. Epidemiology 21:3-9, 2010. File
  • Select activity Assignment: Problem Set 4

    Assignment: Problem Set 4

  • Select activity Problem Set 4 Disease Association 2013

    

    Problem Set 4 Disease Association 2013 File
  • Select activity Assignment Due Date:  October 15, 2013

    Assignment Due Date:  October 15, 2013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, October 8, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, October 8, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, October 15, 2013; 8:45 AM - 10:15 AM

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  Tuesday, October 15, 2013; 8:45 AM - 10:15 AM

  Lecture: Measures of Disease Association II and Measures of Attribution

  Measures of association in a case-control study; equivalence of odds ratio to other measures of association depending on control sampling: case-cohort, incidence density, or prevalent; measures of attribution: attribution among exposed vs attribution in an overall population.

  Faculty:  Ann Schwartz
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Disease Association II and Attribution 2013

    

    Disease Association II and Attribution 2013 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Ch. 3, Includes sections 3.2.2 and 3.4....

    S & N: Ch. 3, Includes sections 3.2.2 and 3.4.2; Appendix A4 and A5 (p. 438 - 442)

  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Greenland S and Robins JM. Conceptual problems in the definition and interpretation of attributable fractions. American Journal of Epidemiology 128:1185-1197, 1988.

    

    Greenland S and Robins JM. Conceptual problems in the definition and interpretation of attributable fractions. American Journal of Epidemiology 128:1185-1197, 1988. File
  • Select activity Rockhill B, Newman B, and Weinberg C. Use and misuse of population attributable fractions. American Journal of Public Health 88:15-19, 1998.

    

    Rockhill B, Newman B, and Weinberg C. Use and misuse of population attributable fractions. American Journal of Public Health 88:15-19, 1998. File
  • Select activity Rundle AG, Vineis P, and Ahsan H. Design options for molecular epidemiology research within cohort studies. Cancer Epidemiol Biomarkers Prev. 14:1899-907, 2005.

    

    Rundle AG, Vineis P, and Ahsan H. Design options for molecular epidemiology research within cohort studies. Cancer Epidemiol Biomarkers Prev. 14:1899-907, 2005. File
  • Select activity Assignment: Problem Set 5

    Assignment: Problem Set 5

  • Select activity Problem Set 5 Disease Association II 2013

    

    Problem Set 5 Disease Association II 2013 File
  • Select activity fracturegenotype

    

    fracturegenotype File
  • Select activity Assignment Due Date:  October 22, 2013

    Assignment Due Date:  October 22, 2013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, October 15, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, October 15, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, October 15, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

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  Tuesday, October 15, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

  Journal Club

  Application of concepts learned in the course to date in the critical dissection of an article in the applied literature
  
  

  Faculty:  Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere
  
  Location:  Students will stay in the rooms of their prior small group sections. Semeere Online.
  

  • Select activity Required Reading:

    Required Reading:

  • Select activity Grosso et al. Oral Bisphosphonates and Risk of Atrial Fibrillation and Flutter in Women: A Self-Controlled Case-Series Safety Analysis. PLoS ONE 4:e4720, 2009

    

    Grosso et al. Oral Bisphosphonates and Risk of Atrial Fibrillation and Flutter in Women: A Self-Controlled Case-Series Safety Analysis. PLoS ONE 4:e4720, 2009 File
  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, October 22, 2013; 8:45 AM - 10:15 AM

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  Tuesday, October 22, 2013; 8:45 AM - 10:15 AM

  Lecture: Selection Bias

  Internal vs. external validity; definition and classification of bias; distinguishing bias from random error; spotting and minimizing selection bias in descriptive, cross-sectional, case-control, and longitudinal (e.g., cohorts or trials) studies

  Faculty:  Jeffrey Martin
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Selection Bias 2013 Final Post

    

    Selection Bias 2013 Final Post File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N:  Ch. 4, sections 4.1 - 4.2 (p. 109 - 11...

    S & N:  Ch. 4, sections 4.1 - 4.2 (p. 109 - 116) and sections 4.4 - 4.4.2 (p. 133 - 139)

  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 15:615-25, 2004.

    

    Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 15:615-25, 2004. File
  • Select activity Robinson et al. Systematic review identifies number of stategies importance for retaining study participants. J Clin Epi 60:757-765, 2007.

    

    Robinson et al. Systematic review identifies number of stategies importance for retaining study participants. J Clin Epi 60:757-765, 2007. File
  • Select activity Assignment: Problem Set 6

    Assignment: Problem Set 6

  • Select activity Problem Set 6 Selection Bias 2013

    

    Problem Set 6 Selection Bias 2013 File
  • Select activity Assignment Due Date:  October 29, 3013

    Assignment Due Date:  October 29, 3013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, October 22, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, October 22, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, October 29 2013; 8:45 AM - 10:15 AM

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  Tuesday, October 29 2013; 8:45 AM - 10:15 AM

  Lecture: Understanding Measurement: Aspects of Reproducibility and Validity

  Distinguishing reproducibility from validity; how reproducibility influences validity; methods of characterizing reproducibility of measurements (within-subject standard deviation, intraclass correlation coefficient,  coefficient of variation); methods of assessment of validity in the presence and absence of gold standards

  Faculty:  Jeffrey Martin
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Measurement Reproducibility Validity 2013 Final Post

    

    Measurement Reproducibility Validity 2013 Final Post File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Chapter 8 : Sections 8.1 - 8.2 (p. 313 ...

    S & N: Chapter 8 : Sections 8.1 - 8.2 (p. 313 - 315), sections 8.3.1 - 8.3.3 (p. 318 - 328), and section 8.4.2 (p. 348 - 358)

  • Select activity Bland and Altman. Measurement error proportional to the mean. BMJ 313:106, 1996.

    

    Bland and Altman. Measurement error proportional to the mean. BMJ 313:106, 1996. File
  • Select activity Bland and Altman. Measurement error and correlation coefficients. BMJ 313:41-42, 1996

    

    Bland and Altman. Measurement error and correlation coefficients. BMJ 313:41-42, 1996 File
  • Select activity Bland and Altman. Measurement error. BMJ 313:744, 1996.

    

    Bland and Altman. Measurement error. BMJ 313:744, 1996. File
  • Select activity Mc Dowell and Newell. Measuring Health: A guide to rating scales and questionnaires. Oxford 29-37, 1996 1996.

    

    Mc Dowell and Newell. Measuring Health: A guide to rating scales and questionnaires. Oxford 29-37, 1996 1996. File
  • Select activity Bland and Altman. Applying the right statistics: analyses of measurement studies. Ultrasound Obstet Gynecol 22: 85-93, 2003.

    

    Bland and Altman. Applying the right statistics: analyses of measurement studies. Ultrasound Obstet Gynecol 22: 85-93, 2003. File
  • Select activity Bland and Altman. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 307-310, 1986.

    

    Bland and Altman. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 307-310, 1986. File
  • Select activity Measurement Summary Chart 2013

    

    Measurement Summary Chart 2013 File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Weir, JP. Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. JSCR 19:231-240, 2005.

    

    Weir, JP. Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. JSCR 19:231-240, 2005. File
  • Select activity Assignment: Problem Set 7

    Assignment: Problem Set 7

  • Select activity Problem Set 7 Understanding Measurement 2013

    

    Problem Set 7 Understanding Measurement 2013 File
  • Select activity Tips for MS Excel

    

    Tips for MS Excel File
  • Select activity Assignment Due Date:  November 5, 2013

    Assignment Due Date:  November 5, 2013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, October 29, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, October 29, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, October 29, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

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  Tuesday, October 29, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

  Journal Club

  Application of concepts learned in the course to date in the critical dissection of an article in the applied literature
  
  

  Faculty:  Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere
  
  Location:  Students will stay in the rooms of their prior small group sections. Semeere (online)
  

  • Select activity Required Reading:

    Required Reading:

  • Select activity Lane et al. Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly caucasian women. Arthritis and Rheumatism 56:3319–3325, 2007.

    

    Lane et al. Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly caucasian women. Arthritis and Rheumatism 56:3319–3325, 2007. File
  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, November 5, 2013; 8:45 AM - 10:15 AM

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  Tuesday, November 5, 2013; 8:45 AM - 10:15 AM

  Lecture: Measurement Bias
  Differential vs non-differential misclassification; independent vs dependent errors;  influence (magnitude and direction of bias) of differential vs. non-differential and independent vs dependent misclassification of exposure, outcome, and confounding variables

  Faculty:  Jeffrey Martin
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Measurement Bias 2013 Final Post

    

    Measurement Bias 2013 Final Post File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N:  Ch. 4: sections 4.3-4.3.3 (P. 116-133)

    S & N:  Ch. 4: sections 4.3-4.3.3 (P. 116-133)

  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Shahar, E. Causal diagrams for encoding and evaluation of information bias. Journal of Evaluation in Clinical Practice 15: 436-440, 2009.

    

    Shahar, E. Causal diagrams for encoding and evaluation of information bias. Journal of Evaluation in Clinical Practice 15: 436-440, 2009. File
  • Select activity Jurek AM et. Proper interpretation of non-differential misclassification effects. J Epid 34:680-687, 2005.

    

    Jurek AM et. Proper interpretation of non-differential misclassification effects. J Epid 34:680-687, 2005. File
  • Select activity Berry et al. Impact of misclassification of in vitro fertilisation in studies of folic acid and twinning: modelling using population based Swedish vital records. BMJ 1-3, 2004.

    

    Berry et al. Impact of misclassification of in vitro fertilisation in studies of folic acid and twinning: modelling using population based Swedish vital records. BMJ 1-3, 2004. File
  • Select activity Hernan and Cole. Causal diagrams and measurement bias. AJE 170:959-962, 2009.

    

    Hernan and Cole. Causal diagrams and measurement bias. AJE 170:959-962, 2009. File
  • Select activity Kristensen P. Bias from nondifferential but dependent misclassification of exposure and outcome. Epidemiology 3:210-215, 1992.

    

    Kristensen P. Bias from nondifferential but dependent misclassification of exposure and outcome. Epidemiology 3:210-215, 1992. File
  • Select activity Assignment: Problem Set 8

    Assignment: Problem Set 8

  • Select activity Problem Set 8 Measurement Bias 2013

    

    Problem Set 8 Measurement Bias 2013 File
  • Select activity Assignment Due Date:  November 12, 2013

    Assignment Due Date:  November 12, 2013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, November 5, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, November 5, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, November 12, 2013; 8:45 AM - 10:15 AM **Note: THIS WEEK ONLY THE LECTURE WILL ONLY BE AVAILABLE VIA VIDEOTAPE RECORDING. AT 9 AM, THE FACULTY WILL HOST A GENERAL QUESTION & ANSWER SESSION FOR MATERIAL COVERED TO DATE.**

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  Tuesday, November 12, 2013; 8:45 AM - 10:15 AM **Note: THIS WEEK ONLY THE LECTURE WILL ONLY BE AVAILABLE VIA VIDEOTAPE RECORDING. AT 9 AM, THE FACULTY WILL HOST A GENERAL QUESTION & ANSWER SESSION FOR MATERIAL COVERED TO DATE.**

  Lecture: Confounding and Interaction I: General Principles
  

  Definition and manifestations of confounding; requirements for confounding variables; use of directed acyclic graphs (DAGs) to demonstrate and identify confounding; extraneous causal pathways; importance of defining the research question and the biological system to prevent confounding

  Faculty:  Jeffrey Martin
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Confounding I 2013 Final Post

    

    Confounding I 2013 Final Post File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Ch. 5

    S & N: Ch. 5

  • Select activity Causal Inference and Extraneous Factors: Confounding and Interaction. In Statistics for Epidemiology. Nicholas P. Jewell. Chapman and Hall. 2003: p. 93-112.

    

    Causal Inference and Extraneous Factors: Confounding and Interaction. In Statistics for Epidemiology. Nicholas P. Jewell. Chapman and Hall. 2003: p. 93-112. File
  • Select activity dagitty.net, an open source browser-based environm...

    dagitty.net, an open source browser-based environment for creating, editing, and analyzing directed acyclic graphs

  • Select activity Using DAGitty dot net 2013

    

    Using DAGitty dot net 2013 File
  • Select activity Notes on reading for Confounding and Interaction I

    

    Notes on reading for Confounding and Interaction I File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Hernan M. Causal knowledge. AJE 156:176-184, 2002.

    

    Hernan M. Causal knowledge. AJE 156:176-184, 2002. File
  • Select activity Cole S, Hernan M. Fallibility in estimating direct effects. IJE 31:163-165, 2002.

    

    Cole S, Hernan M. Fallibility in estimating direct effects. IJE 31:163-165, 2002. File
  • Select activity Assignment: Problem Set 9

    Assignment: Problem Set 9

  • Select activity Problem Set 9 Confounding and Interaction I 2013

    

    Problem Set 9 Confounding and Interaction I 2013 File
  • Select activity Assignment Due Date:  November 19, 2013

    Assignment Due Date:  November 19, 2013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, November 12, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, November 12, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, November 12 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

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  Tuesday, November 12 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

  Journal Club

  Application of concepts learned in the course to date in the critical dissection of an article in the applied literature
  
  

  Faculty:  Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere
  
  Location:  Students will stay in the rooms of their prior small group sections. Semeere (Online)
  

  • Select activity Required Reading:

    Required Reading:

  • Select activity Rookus M and van Leeuwen FE. Induced abortion and risk for breast cancer. Reporting (recall) bias in a Dutch case-control stduy. Journal of the National Cancer Institute 88:1759-1764, 1996.

    

    Rookus M and van Leeuwen FE. Induced abortion and risk for breast cancer. Reporting (recall) bias in a Dutch case-control stduy. Journal of the National Cancer Institute 88:1759-1764, 1996. File
  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, November 19, 2013; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

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  Tuesday, November 19, 2013; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

  Lecture: Confounding and Interaction II: Assessment of Interaction
  

  Strategies to minimize confounding; distinguishing interaction (effect measure modification) from confounding; assessing for interaction; tests of homogeneity; computer implementation

  Faculty:  Jeffrey Martin
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Confounding and Interaction II 2013 Final Post

    

    Confounding and Interaction II 2013 Final Post File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity S & N: Ch. 6 and Ch. 1, section 1.4.5 (p. 33 -...

    S & N: Ch. 6 and Ch. 1, section 1.4.5 (p. 33 - 38, section on Matching)

    dagitty.net, an open source browser-based environment for creating, editing, and analyzing directed acyclic graphs

  • Select activity Optional Reading:

    Optional Reading:

  • Select activity VanderWeele TJ and Robins JM. Four types of effect modification: A classification based on directed acyclic graphs. Epidemiology 18: 561-568, 2007.

    

    VanderWeele TJ and Robins JM. Four types of effect modification: A classification based on directed acyclic graphs. Epidemiology 18: 561-568, 2007. File
  • Select activity Knol MJ et al. When one depends on the other: Reporting of interaction. Epidemiology 20:161-166, 2009.

    

    Knol MJ et al. When one depends on the other: Reporting of interaction. Epidemiology 20:161-166, 2009. File
  • Select activity Knol MJ and VanderWeele TJ. Recommendations for presenting analyses of effect modification and interaction. International Journal of Epidemiology 41:514-520, 2012.

    

    Knol MJ and VanderWeele TJ. Recommendations for presenting analyses of effect modification and interaction. International Journal of Epidemiology 41:514-520, 2012. File
  • Select activity Assignment: Problem Set 10

    Assignment: Problem Set 10

  • Select activity Problem Set 10 Confounding and Interaction II 2013

    

    Problem Set 10 Confounding and Interaction II 2013 File
  • Select activity Assignment Due Date:  November 26, 2013

    Assignment Due Date:  November 26, 2013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, November 19, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, November 19, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, November 26, 2013; 8:45 AM - 10:15 AM

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  Tuesday, November 26, 2013; 8:45 AM - 10:15 AM

  Lecture: Confounding and Interaction III: Stratified Analysis

  Concept of weighted averages; use of stratification to form adjusted measures; managing multiple confounding paths; software implementation to detect minimally sufficient set for adjustment; limitations of stratification including time-dependent confounding/mediation

  Faculty:  Jeffrey Martin
  
  Location:  China Basin 6702

  • Select activity Session Slides:

    Session Slides:

  • Select activity Confounding and Interaction III 2013 Final Post

    

    Confounding and Interaction III 2013 Final Post File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading: S & N: Ch. 7: sections 7.1 ...

    Required Reading:

    S & N: Ch. 7: sections 7.1 - 7.2.1 (p. 229 - 234) and sections 7.3.3 - 7.3.4 (p. 242 - 248)

    dagitty.net, an open source browser-based environment for creating, editing, and analyzing directed acyclic graphs

  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Shrier I and Platt W. Reducing bias through directed acyclic graphs. BMC Medical Research Methodology, 8:70, 2008.

    

    Shrier I and Platt W. Reducing bias through directed acyclic graphs. BMC Medical Research Methodology, 8:70, 2008. File
  • Select activity Suraez et al. Differences between marginal structural models and conventional models in their exposure effect estimates. Epidemiology 22: 586-588, 2011.

    

    Suraez et al. Differences between marginal structural models and conventional models in their exposure effect estimates. Epidemiology 22: 586-588, 2011. File
  • Select activity Assignment: Problem Set 11

    Assignment: Problem Set 11

  • Select activity Problem Set 11 Confounding and Interaction III 2013

    

    Problem Set 11 Confounding and Interaction III 2013 File
  • Select activity esophageal cancer

    

    esophageal cancer File
  • Select activity Assignment Due Date:  December 3, 2013

    Assignment Due Date:  December 3, 2013

  • Select activity Assignment Answer Key (Access restricted to regist...

    Assignment Answer Key (Access restricted to registered students):

• Select section Tuesday, November 26, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, November 26, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Tuesday, November 26, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

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  Tuesday, November 26, 2013; 3:15 PM - 4:15 PM (Times and dates for online sessions may differ)

  Journal Club

  Application of concepts learned in the course to date in the critical dissection of an article in the applied literature
  
  

  Faculty:  Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere
  
  Location:  Students will stay in the rooms of their prior small group sections. Semeere Online

  • Select activity Required Reading:

    Required Reading:

  • Select activity Nitz et al. Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. Journal of Clinical Endocrinology & Metabolism 92:3183–3188, 2007.

    

    Nitz et al. Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. Journal of Clinical Endocrinology & Metabolism 92:3183–3188, 2007. File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity Lunnetta KL. Genetic association studies. Circulation 118:96-101, 2008.

    

    Lunnetta KL. Genetic association studies. Circulation 118:96-101, 2008. File
  • Select activity EPI203 JournalClub Genetic Diabetes Glossary

    

    EPI203 JournalClub Genetic Diabetes Glossary File
• Select section Tuesday, December 3, 2013; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

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  Tuesday, December 3, 2013; 8:45 AM - 10:15 AM (Times and dates for online sessions may differ)

  Journal Club

  Application of concepts learned in the course to date in the critical dissection of an article in the applied literature
  
  

  Faculty:  Jeff Martin
  
  Location:  China Basin 6702
  

  • Select activity Session Slides:

    Session Slides:

  • Select activity MMR and Autism NEJM 2002 2013 Final Post

    

    MMR and Autism NEJM 2002 2013 Final Post File
  • Select activity Course Finale Comments 2013

    

    Course Finale Comments 2013 File
  • Select activity Session Audio/Video Recording (Access restricted t...

    Session Audio/Video Recording (Access restricted to registered students):

  • Select activity Required Reading:

    Required Reading:

  • Select activity Madsen et al., A population-based study of measles, mumps, and rubella vaccination and autism. NEJM 347:1477-82, 2002.

    

    Madsen et al., A population-based study of measles, mumps, and rubella vaccination and autism. NEJM 347:1477-82, 2002. File
  • Select activity Optional Reading:

    Optional Reading:

  • Select activity EPI 203 Writing a Manuscript Template

    

    EPI 203 Writing a Manuscript Template File
  • Select activity von Elm et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Lancet 370:1453-1457, 2007.

    

    von Elm et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. Lancet 370:1453-1457, 2007. File
  • Select activity Vandenbroucke et al. Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration. PLoS Medicine 4:e297, 2007.

    

    Vandenbroucke et al. Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration. PLoS Medicine 4:e297, 2007. File
  • Select activity Assignment: Final Exam

    Assignment: Final Exam

  • Select activity Epi Methods Final Fall 2013

    

    Epi Methods Final Fall 2013 File
  • Select activity Yaggi et al. Obstructive sleep apnea as a risk factor for stroke and death. NEJM 353:2034-41. 2005.

    

    Yaggi et al. Obstructive sleep apnea as a risk factor for stroke and death. NEJM 353:2034-41. 2005. File
  • Select activity brcarctv6

    

    brcarctv6 File
  • Select activity Assignment Due Date:  December 10, 2013 by 4pm, em...

    Assignment Due Date:  December 10, 2013 by 4pm, emailed or delivered to Olivia De Leon

• Select section Tuesday, December 3, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

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  Tuesday, December 3, 2013; 1:30 PM - 3:00 PM (Times and dates for online sessions may differ)

  Small Group Discussion Section
  Review of prior lecture and problem set

  Faculty: Miriam Laker-Oketta, Heidi Moseson, Martina Steurer, Christina Yoon, Alexis Beatty, Trisha Hue, Jeff Martin, Ann Schwartz, Aggrey Semeere

  Location:  Laker-Oketta CB 6702, Moseson CB 6601, Steurer CB 5759, Yoon CB 5721, Semeere Online
• Select section Note:

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  Note:

   
• Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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  Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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• Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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  Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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• Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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  Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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• Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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  Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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• Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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  Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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• Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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  Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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• Select section Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

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  Tuesday, July 30, 2013; 1:15 PM - 2:45 PM (Times and dates for online sessions may differ)

  Not available