Section outline

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  • Thursday, January 6, 2022, 1:10 PM - 3:00 PM

     

    Course Introduction & Conceptual Frameworks for Causal Inference (Parts I & II)

    Introduction to the course; models/heuristics for causal inference in epidemiology; discussion of counterfactuals and identifiability criteria; ideal randomized experiments

    Faculty: June Chan, Rebecca Graff

    Location: ONLINE--Zoom link below

    • Required Reading:

      Chapter 1 and Chapter 2.1, Hernán & Robins, Causal Inference Book, online

    • Optional Reading:

      Chapter 2, Rothman, Greenland, & Lash, 2008

    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Welcome and Overview to EPI 207 2022 Media Resource
    • Conceptual Frameworks for Causal Inference - Part 1 Media Resource

      Updated 12/28/21 with additional clarifications

    • Bradford Hill (Optional) Media Resource
    • Sufficient & Component Cause (Optional) Media Resource

    • Session Slides:

    • Welcome and Overview EPI 207 2022 File PPTX
      Uploaded 12/19/21, 14:03
    • Opening Slides for Jan 6 2022 EPI207_Chan File
      Uploaded 01/5/22, 15:29
    • Conceptual Frameworks for Causal Inference - Part 1 File

      Updated 12/28/21 with additional clarifications

      Uploaded 12/28/21, 15:14
    • Conceptual Frameworks for Causal Inference - Part 2 File
    • Bradford Hill (Optional) File
    • Sufficient & Component Cause (Optional) File
    • Notation and Probability Review Lecture (Optional) File

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment:

      Due Thursday, January 20, 2022 at the beginning of lecture

    • Conceptual Frameworks for Causal Inference Homework Questions File
    • Article to Read for HW - Karasek, et al. Lancet Reg Health Am 2021 File
      Not available unless: You belong to Registered Students Only
    • Homework #1 Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

  • Monday, January 10, 2022, 4:00 PM - 4:45 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

  • Thursday, January 13, 2022, 1:10 PM - 2:00PM

    Conceptual Frameworks for Causal Inference (Parts III & IV)
    Conditional randomization, standardization, inverse probability weighting

    Faculty: Rebecca Graff

    Location: ONLINE--Zoom link below


    • Required Reading:

      Chapters 2.2-2.4, Hernán & Robins, Causal Inference Book, online

    • Optional Reading:

      Chapter 3, Hernán & Robins, Causal Inference Book, online


    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Conceptual Frameworks for Causal Inference - Part 3 Media Resource

    • Session Slides:

    • Conceptual Frameworks for Causal Inference - Part 3 File
      Uploaded 01/4/22, 17:34
    • Conceptual Frameworks for Causal Inference - Part 4 File
      Uploaded 01/4/22, 17:54
    • Conceptual Frameworks for Causal Inference - Part 4 with Answers to Exercises File
    • Conceptual Frameworks for Causal Inference - All Parts File
      Uploaded 01/4/22, 18:04
    • Conceptual Frameworks for Causal Inference - All Parts with Answers to Exercises File

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 2 - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Miscellaneous:

    • OPTIONAL Standardization Exercise File
    • OPTIONAL Standardization Exercise Solution File

  • Thursday, January 13, 2022, 2:00 PM - 3:00 PM

    DAGs (Parts I & II)

    How to draw and use directed acyclic graphs; d-separation; DAGs to represent confounding

    Faculty:  Rebecca Graff

    Location: ONLINE--Zoom link below


    • Required Reading (please read PRIOR to watching the lectures):

      1. Chapter 6.1 - 6.3, Hernán & Robins, Causal Inference Book, online
      2. Chapter 7.1 - 7.4, Hernán & Robins, Causal Inference Book, online

    • Optional Reading:

      1. Chapters 6.4 - 6.6 and 7.5 - 7.6, Hernán & Robins, Causal Inference Book, online
      2. Chapter 12, Rothman, Greenland, & Lash, 2008
      3. Digitale JC, Martin JN, Glymour MM. Tutorial on directed acyclic graphs. J Clin Epidemiol. In Press. https://pubmed-ncbi-nlm-nih-gov.ucsf.idm.oclc.org/34371103/

    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Directed Acyclic Graphs - Part 1 Media Resource

    • Session Slides:

    • Directed Acyclic Graphs - Part 1 File
    • Directed Acyclic Graphs - Part 2 File
    • Directed Acyclic Graphs - Part 2 with Answers to Exercises File
      Uploaded 01/12/22, 13:20

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 2 - Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment:

      Due Thursday, January 27, 2022 at the beginning of lecture

    • Directed Acyclic Graphs Homework Questions File
    • Article to Read for HW - Hernan, et al. Ann Neurol 2001 File
      Not available unless: You belong to Registered Students Only
    • Homework #2 Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

    • Directed Acyclic Graphs Homework Answer Key File
      Not available unless: You belong to a group in Registered Students Only
      Uploaded 02/16/22, 23:38

  • Tuesday, January 18, 2022, 1:10 PM - 2:00 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes


    • Session Audio/Video Recording (access restricted to registered students):

    • Office Hours Recording Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Thursday, January 20, 2022, 1:10 PM - 2:10 PM

    DAGs (Parts III & IV)

    DAGs to represent selection bias and measurement bias; limitations of DAGs

    Faculty: Rebecca Graff

    Location: ONLINE--Zoom link below

    • Required Reading (please read PRIOR to watching the lectures):

      1. Chapter 8.1 - 8.3, Hernán & Robins, Causal Inference Book, online
      2. Chapter 9.1 - 9.3, Hernán & Robins, Causal Inference Book, online

    • Optional Reading:

      1. Chapter 8.4 - 8.5, Hernán & Robins, Causal Inference Book, online
      2. Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 2004 Sep 1;15(5):615-25. (This was a very influential paper that reconceptualized how we think about selection bias). https://www.ncbi.nlm.nih.gov/pubmed/15308962 

      3. VanderWeele TJ, Hernán MA. Results on differential and dependent measurement error of the exposure and the outcome using signed directed acyclic graphs. Am J Epidemiol. 2012 May 8;175(12):1303-10. https://www.ncbi.nlm.nih.gov/pubmed/22569106

    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Directed Acyclic Graphs - Part 3 Media Resource

    • Session Slides:

    • Directed Acyclic Graphs - Part III File
    • Directed Acyclic Graphs - Part IV File
    • Directed Acyclic Graphs - Part IV with Answers to Exercises File
    • Directed Acyclic Graphs - All Parts File
    • Directed Acyclic Graphs - All Parts with Answers to Exercises File

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 3 - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Class Recording - Week 3 - Part 1 - Transcript File
      Not available unless: You belong to Registered Students Only
    • Recording of 2021 DAGs Lecture Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Thursday, January 20, 2022, 2:10 PM - 3:00 PM

    Homework #1 Review: Conceptual Frameworks for Causal Inference

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    Location: ONLINE--Zoom link below

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 3 - Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Class Recording - Week 3 - Part 2 - Transcript File
      Not available unless: You belong to Registered Students Only

  • Monday, January 24, 2022, 4:10 PM - 5:00 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    • Session Audio/Video Recording (access restricted to registered students):

    • Office Hours Recording Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Thursday, January 27, 2022, 1:10 PM - 2:10 PM

    Target Trials


    Strengths and limitations of randomized clinical trials; similarities and differences between components of randomized clinical trials and observational studies; application of using a “target trial” to make causal inferences from cohort studies.

    Faculty:  June Chan

    Location: ONLINE--Zoom link below

    • Required Reading (please read PRIOR to watching the lectures):

      Rothman, Greenland and Lash 2008 (RGL), Modern Epidemiology, Ch. 6 (focus on RCT and COH) & skim Chapter 7. Please note, RGL Chapter 7 will also be assigned for a future lecture on Person Time/Bias in Cohorts.


    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Target Trials - Part 1 W22 Media Resource

    • There is no recording associated with the Target Trials - Part 2 slides. Please review the slides below (acknowledgement: Dr. Deborah Grady).

    • Target Trials - Part 3 Media Resource

    • Session Slides:

    • Target Trials - Part 1 W22 File
      Uploaded 01/19/22, 11:49
    • Target Trials - Part 2 W22 File
      Uploaded 01/19/22, 11:50
    • Target Trials - Part 3 W22 File
      Uploaded 01/19/22, 11:51
    • Target Trials - Part 4 (In-Class) & Appendix W22 File
      Uploaded 01/27/22, 11:31
    • In-Class Exercise Target Trials Sample Answers W22 File
      Not available unless: You belong to Registered Students Only
      Uploaded 01/27/22, 11:33
    • Target Trials - All Parts incl Appendix File
      Uploaded 01/27/22, 11:35

    • Session Audio/Video Recording (Access restricted to registered students):

    • Class Recording - Week 4 - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment:

      Due Thursday, February 3, 2022 at the beginning of lecture

    • Article to Read for HW - Lawson, et al. J Natl Cancer Inst 2007 File
      Not available unless: You belong to a group in Registered Students Only
    • EPID 207 W22 Target Trials HW Questions File
      Not available unless: You belong to Registered Students Only
      Uploaded 01/27/22, 10:10
    • Homework #3 Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

    • Baseline AARP Diet Questionnaire (Supplemental FYI Only) File
    • EPI207 RCT Coh Target Trials KEY ONLY to POST File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/3/22, 10:57

  • Thursday, January 27, 2022, 2:10 PM - 3:00 PM

    Homework #2 Review: DAGs

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    Location: ONLINE--Zoom link below

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 4 - Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Monday, January 31, 2022, 4:00 PM - 5:00 PM

    Office Hours: 

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    • Session Audio/Video Recording (access restricted to registered students):

    • Office Hours Recording Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Thursday, February 3, 2022, 1:10 PM - 2:10 PM

    Matching in Observational Studies

    Purpose of matching; matching in cohort and case-control studies; case-crossover studies

    Faculty:  Rebecca Graff

    • Required Reading (please read PRIOR to watching the lectures):

                     Chapter 8, pages 171-182, and page 605 Rothman, Greenland, & Lash, 2008


    • Mansournia, et al. Int J Epidemiol 2013 File
      Not available unless: You belong to a group in Registered Students Only

    • Optional Reading:

      Pages 283-288, 434-435 Rothman, Greenland, & Lash, 2008


    • Pearce BMJ 2016 File
      Not available unless: You belong to a group in Registered Students Only
    • Dennekamp, et al. Environ Health Perspect 2015 File
      Not available unless: You belong to a group in Registered Students Only

    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Matching in Observational Studies - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Matching in Observational studies - Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only
    • Matching in Observational Studies - Part 3 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Session Slides:

    • Matching in Observational Studies - Part 1 File
    • Matching in Observational Studies - Part 2 File
    • Matching in Observational Studies - Part 3 File
    • Matching in Observational Studies - Part 4 File
    • Matching in Observational Studies - Part 4 with Answers to Exercises File
    • Matching in Observational Studies - All Parts File
    • Matching in Observational Studies - All Parts with Answers to Exercises File
    • In-Class Exercise File

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 5 - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment:

      Due Thursday, February 10, 2022 at the beginning of lecture

    • Matching in Observational Studies Homework Questions File
      Uploaded 02/6/22, 16:59
    • Article to Read for HW - Nevriana, et al. CNS Drugs 2017 File
      Not available unless: You belong to a group in Registered Students Only
    • Homework #4 Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

    • Matching in Observational Studies Homework Answer Key File
      Not available unless: You belong to a group in Registered Students Only

  • Thursday, February 3, 2022, 2:10 PM - 3:00 PM

    Homework #3 Review: Target Trials

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 5 - Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Monday, February 7, 2022, 4:10 PM - 5:00 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    • Session Audio/Video Recording (access restricted to registered students):

    • Office Hours Recording Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Thursday, February 10, 2022 1:10 PM - 2:10 PM

    Lecture: Interaction/Effect Modification

    Faculty: June Chan 

    BEFORE class on Feb. 10, 2022, please do the readings and view/review Parts 1-4 of Interaction/Effect Modification (listed on Feb. 10). You are responsible for the material in all parts, however note that Parts 1, 2a, and 2b may be more of a “review” for some. In particular, parts 2a and 2b may have been recently covered in BIO208. For these sections, you may wish to skim the slides, to ensure that you are familiar with the material but may opt not to watch the video lectures. Part 3 is a slide deck of definitions only (no video), and we will review some of this during the live lecture on 2/10. In the live lecture on 2/10, we will also be focusing on discussing interaction using the counterfactual framework.

    • Required Reading:

      VandeerWeele & Knol, “A Tutorial on Interaction”, Epidemiol Methods 2014, PARTS 1.1-1.7 only (parts 1.8, 1.9 and 2 are optional)

      Chapter 5, p. 71-76 (the rest of the chapter is optional) Rothman/Greenland/Lash 2008, Modern Epidemiology 3rd edition


    • VanderWeele.InteractionTutorial 2014 clean to post File
      Not available unless: Your ID number contains 02

    • Optional Reading:

      Hernan & Robins, Causal Inference online book, Ch. 4.1-4.3 and Ch. 5.1-5.3


    • Knol et al Int J Epid 2007 Interaction on Additive Scale File
      Not available unless: Your ID number contains 02

    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Part 1 Intro Interaction EffMod Media Resource
    • Part 2a_rec_Model Coeff_Interaction EffMod v2 Media Resource
    • Part 2b_rec_Model Coeff_Interaction EffMod v2 Media Resource
    • No video for Part 3
    • Part4 rec Presenting EffMod Media Resource
    • Part 6 AFTER live lec EPID207 W22 Intro to Interaction App by Francois Rerolle_Recorded Lec Media Resource
      Not available unless: You belong to Registered Students Only

    • Session Slides:

    • Part 1 Intro Interaction EffMod winter 2022 File
      Uploaded 02/2/22, 21:13
    • Part 2a rec Model Coeff Interaction EffMod 22 File
      Uploaded 02/2/22, 21:18
    • Part 2b rec Model Coeff Interaction EffMod 22 File
      Uploaded 02/2/22, 21:19
    • Part3 NOT Recorded EffMod 22 File
      Uploaded 02/2/22, 21:19
    • Part 4 Presenting EffMod winter 22_corrected file
      Uploaded 02/9/22, 16:06
    • Part 5 EM_Interaction InClass Recap Metrics and Counterfactual Framework File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/10/22, 13:12
    • No slides for Part 6, recorded lecture by Francois Rerolle; video only
    • OPTIONAL Appendix NOT Recorded Interaction EffMod - Extra Slides MMG File
      Uploaded 02/2/22, 21:28
    • ALL Parts 1_6 and Appendix EM_Interaction W22 File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/10/22, 13:08

    • Session Audio/Video Recording (Access restricted to registered students):

    • Class Recording - Week 6 - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment:

      Due Thursday, February 17, 2022 at the beginning of lecture. Note, for this HW assignment, you will need to access the online "app" below.

      https://francoisrerolle.shinyapps.io/epi_207_interaction_app/

    • EM and Interaction HW Ques W22 File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/9/22, 20:01
    • Dataset for Interaction HW File
      Not available unless: You belong to Registered Students Only
    • Homework #5 Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

    • W22 EM Interaction HW Answ Key to POST File
      Not available unless: You belong to a group in Registered Students Only
      Uploaded 02/17/22, 08:52

  • Thursday, February 10, 2022, 2:10 PM - 3:00 PM

    Homework #4 Review: Matching

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    • Session Audio/Video Recording (access restricted to registered students):

    • Class Recording - Week 6 - Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Monday, February 14, 2022, 4:00PM - 5:00 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

  • Thursday, February 17, 2022, 1:10 PM - 2:10 PM

    Lecture: Person-time and Bias 

    Fixed vs. open cohorts; the dynamic allocation of person-time in longitudinal cohorts; patient or survivor cohorts; particular bias issues discussed in the setting of patient cohorts (including selection bias, immortal-person time bias, measurement error bias, confounding by indication, and residual confounding); and how emulation of a target trial may help avoid some of these biases.

    Faculty: June Chan

    View Parts 1-3 of Person-time and Bias lecture BEFORE coming to class on Feb 17, 2022.


    • Required Reading (please read PRIOR to watching the lectures):

      Chapter 7, Rothman, Greenland, & Lash 3rd Edition

    • Recommended Reading:

      Optional Reading:

      Emilsson L, García-Albéniz X, Logan RW, Caniglia EC, Kalager M, Hernán MA. Examining Bias in Studies of Statin Treatment and Survival in Patients With Cancer. JAMA Oncol. 2018, PubMed PMID: 28822996. https://www.ncbi.nlm.nih.gov/pubmed/28822996 



    • SurvivalAnalysis LEC 2016_OPTIONAL primer on Survival Analysis File

      For those interested in a bit more background information on survival analysis, please see this chapter written by Dr. McCulloch for the UCSF medical students, in 2016. We are sharing this supplemental information with his permission. Please note there may be internal references in this chapter to other texts from that course, which are not relevant for EPI207. (citation: Ch. 65 of the UCSF SOM Mechanisms, Methods, and Malignancy syllabus, 2016, copyright UC Regents)

      Not available unless: You belong to Registered Students Only

    • Recorded Lectures (please watch PRIOR to class):

      Access restricted to registered students

    • Session Slides:

    • PT Bias Part 1 OpenFix Coh and Calcs EPI207_slides_no audio File
      Not available unless: You belong to Registered Students Only
    • PT Bias Part 2 PT EPI207_slides no audio File
      Not available unless: You belong to Registered Students Only
    • PT Bias Part 3 SurvCoh Conf EPI207 no audio File
      Not available unless: You belong to Registered Students Only
    • PT Bias Part 4 Sel Bias ImmPT W22 with InClass QUES ONLY File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/17/22, 11:26
    • W22 PT Bias All DECKS combined with Answ File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/17/22, 11:27
    • PT and Bias W22 InClass Exercise Ques with ANSWERS File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/17/22, 11:28

    • Session Audio/Video Recording (Access restricted to registered students):

    • Class Recording - Week 7 - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Assignment:

      Due Thursday, February 24, 2022 at the beginning of lecture

    • HW PT Bias Ques to Post W22 File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/17/22, 11:29

    • Choe, K.S., et al, Aspirin use and the risk of prostate cancer mortality in men treated with prostatectomy or radiotherapy. 2012, Journal of Clinical Oncology, 30(28), pp.3540-3544.


      Not available unless: You belong to Registered Students Only
    • Homework #6 Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

    • W22 PT Bias KEY to post File
      Not available unless: You belong to Registered Students Only
      Uploaded 02/24/22, 09:45

  • Thursday, February 17, 2022, 2:10 PM - 3:00 PM

    Homework #5 Review: Effect Modification/Interaction

    Instructors: Sarah Goldberg, Carolyn Smith Hughes


    • Session Audio/Video Recording (Access restricted to registered students):

    • Class Recording - Week 7 - Part 2 Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Tuesday, February 22, 2022, 1:00 PM - 2:00 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    • Session Audio/Video Recording (Access restricted to registered students):

    • Office Hours Recording (02-22-22) Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Thursday, February 24, 2022; 1:10 PM - 2:10 PM

    Lecture: DAGs for Advanced Challenges to Validity

    Faculty: June Chan and Rebecca Graff

    • Session Slides:

    • DAGs for Advanced Challenges to Validity File
      Not available unless: You belong to Registered Students Only
    • Class Recording - Week 8 - Part 1 Media Resource
      Not available unless: You belong to a group in Registered Students Only

    • Session Audio/Video Recording (Access restricted to registered students):

  • Thursday, February 24, 2022, 2:10 PM - 3:00 PM

    Homework #6 Review: Person-Time/Bias

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    • Homework 6 review and discussion Media Resource
      Not available unless: You belong to a group in Registered Students Only

  • Monday, February 28, 2022, 4:00 PM - 5:00 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

  • Friday, March 4, 2022, 1:10 PM - 3:00 PM (3:00 PM - 4:00 PM Optional)

    Quantitative Bias Analysis (QBA) 

    The focus of this workshop is methods for conducting quantitative bias analysis in epidemiologic research. We will first provide a brief introduction to confounding, information bias, and selection bias using causal diagrams. Next, we will discuss deterministic and probabilistic bias analysis. Dr. Mayeda will discuss examples of specific biases in her own work on determinants of cognitive decline in older adults. At the end of the workshop, participants should walk away with an understanding of the motivations behind quantitative bias analysis and how to use tools for conducting quantitative bias analysis.

    The first two hours will contain the material for which students in EPI207 are responsible; the last hour is optional for the class.

    Faculty:  Elizabeth Rose Mayeda

    • Files to Download BEFORE Part 2 QBA
      Uploaded 10/20/21, 23:41


    • Required Reading:


    • Orsini N, et al. A tool for deterministic and probabilistic sensitivity analysis of epidemiologic studies. Stata Journal. 2008;8(1):29-48. File
      Not available unless: You belong to Registered Students Only

    • Optional Reading:


    • Mayeda ER, et al. A simulation platform for quantifying survival bias: an application to research on determinants of cognitive decline. American Journal of Epidemiology. 2016 Sep 1;184(5):378-87. (copy) File
      Not available unless: You belong to Registered Students Only
    • Hernán MA, Hernández-Díaz S, Robins JM. A structural approach to selection bias. Epidemiology. 2004;15(5):615-625. File
      Not available unless: You belong to Registered Students Only
    • Fox MP, Lash TL, Greenland S. A method to automate probabilistic sensitivity analyses of misclassified binary variables. International journal of epidemiology. 2005;34(6):1370-1376. File
      Not available unless: You belong to Registered Students Only
    • Last TL, et al. Good practices for quantitative bias analysis. International Journal of Epidemiology. 2014;43(6):1969-1985. File
      Not available unless: You belong to Registered Students Only

    • Session Slides:

    • QBA Part I File
      Uploaded 03/4/22, 12:53
    • QBA Part II File
      Uploaded 03/4/22, 12:54

    • Session Audio/Video Recording (Access restricted to registered students):

    • Class Recording - Week 9 Media Resource
      Not available unless: You belong to Registered Students Only

    • Assignment:

      Due Thursday, March 10, 2022 at the beginning of lecture

    • QBA Homework Questions File
      Uploaded 03/4/22, 12:58
    • Homework #7 Submission Assignment

    • Assignment Answer Key (access restricted to registered students):

    • QBA Homework Answer Key File
      Not available unless: You belong to Registered Students Only

  • Monday, March 7, 2022, 4:00 PM - 5:00 PM

    Office Hours

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

  • Thursday, March 10, 2022, 1:10 PM - 1:45 PM

    Homework #7 Review: QBA

    Instructors: Sarah Goldberg, Carolyn Smith Hughes

    IN-PERSON, Mission Hall 1407

  • Thursday, March 10, 2022, 1:45 PM - 3:00 PM

    Wrap Up

    Faculty: June Chan, Rebecca Graff

    IN-PERSON, Mission Hall 1407


    • Optional Reading:


    • Session Slides:

    • Wrap-up / Review File
      Uploaded 03/10/22, 12:41

    • Session Audio/Video Recording (Access restricted to registered students):

    • Watch - In-Person Session URL
      Not available unless: You belong to a group in Registered Students Only

  • Friday, March 18, 2022; Take-Home Final Exam

    The final exam will be posted by 5:00pm on Thursday, 3/10 and be due by Friday, 3/18 at 11:59pm.

    • Assignment:

      Due Friday, March 18, 2022 at 11:59pm

    • 2022 Epi 207 Final Exam File
      Not available unless: You belong to Registered Students Only
      Uploaded 03/10/22, 12:53
    • Satia, et al. Am J Epidemiol 2009 (Q1-Q4) File
      Not available unless: You belong to Registered Students Only
    • Interaction Simulation App by Francois Rerolle (Q10) URL
    • Final Exam Submission Assignment

    • Optional Reading:


    • [OPTIONAL] Hernán, et al. J Clin Epidemiol 2016 (Q4b) File
      Not available unless: You belong to Registered Students Only
    • [OPTIONAL] Wright, et al. Cancer Causes Control 2003 (Q5) File
      Not available unless: You belong to Registered Students Only
    • [OPTIONAL] Jain, et al. JAMA 2015 (Q8) File
      Not available unless: You belong to Registered Students Only
    • [OPTIONAL] Jain, et al. JAMA 2015 Supplement (Q8) File
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